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Xywav drug has main ingredients including Calcium oxybate, Magnesium oxybate, Potassium oxybate and Sodium oxybate equivalent to 0.5 g/ml, belonging to the group of psychotropic drugs. Xywav is commonly used in the treatment of patients with insomnia and excessive daytime sleepiness (EDS) aged 7 years and older with narcolepsy. Knowing the basic information such as ingredients, uses, doses and unwanted side effects of Xywax medicine will help patients improve treatment effectiveness.
1. What is Xywav?
Xywav drug is prepared in the form of an oral solution, with the main ingredients including:
Active ingredient: Calcium oxybate 0.234 g/ml. Magnesium oxybate 0.096 g/ml. Potassium oxybate 0.13 g/ml. Sodium oxybate 0.04 g/ml. Excipients: Purified water and Sucralose. Mechanism of action:
Xywav is a central nervous system depressant, which reduces insomnia, excessive daytime sleepiness (EDS) and insomnia in patients with narcolepsy, and at the same time corrects and reduce nighttime awakenings.
Xywav is a mixture of Calcium oxybate, Magnesium oxybate, Potassium oxybate and Sodium oxybate also known as Gamma-hydroxybutyrate whose mechanism of action is still unknown, however some studies suggest that Gamma-hydroxybutyrate (GHB) is a endogenous compound, and a metabolite of the neurotransmitter Gamma aminobutyric Acid (GABA). Some theories suggest that the effect of Xywav acts on GABA activities at Noradrenergic, Dopaminergic, and hippocampal neurons, thereby mediating dyssomnia and excessive daytime sleepiness. EDS).
2. What are the uses of Xywav?
Xywav is commonly used to treat cases of insomnia or excessive sleepiness (EDS) in adults and children 7 years of age and older with narcolepsy – Narcolepsy with Cataplexy.
3. Contraindications of the drug Xywav:
Hypersensitivity to any ingredient in Xywav. History of allergy to other drugs containing Calcium oxybate, Magnesium oxybate, Potassium oxybate and Sodium oxybate. People who are being treated with sedative sleeping pills. People with severe depression. People who use alcohol too much. Patients with Succinic semialdehyde dehydrogenase deficiency. This is a rare congenital metabolic disorder characterized by mental retardation, decreased muscle tone, and ataxia. Children < 7 years old or weighing less than 20 kg.
4. Dosage and how to use Xywav
Note:
Take Xywav pills 2 to 3 hours after meals. Carefully read the instructions for use of Xywav before use
5. Notes when using Xywav
Using Xywav in high doses or for a long time can cause side effects such as:
Common: Sleep problems including drowsiness, insomnia, abnormal dreams, sleep paralysis, nightmares, sleepwalking, difficulty falling asleep in the middle of the night, excessive daytime sleepiness. Nervous disorders such as feeling drunk, disorientation, blurred vision, dizziness, tremor, confusion, balance disorder, fall, anxiety, nervousness. Cardiovascular symptoms such as increased blood pressure, palpitations, shortness of breath. Digestive disorders such as anorexia, decreased appetite, nausea, vomiting, weight loss, stomach pain, diarrhea. Respiratory symptoms such as snoring, nasal congestion, nasopharyngitis, sinusitis. Other symptoms such as fatigue, weakness, attention disorders, sensitivity disorders such as decreased touch, abnormal taste, excessive sweating, swelling, joint pain, back pain, muscle cramps, urinary incontinence control, rash. Uncommon: Psychiatric disturbance may be associated with hallucinations, paranoia, abnormal thinking, incoherent speech or disorganized behavior, agitation, suicide attempts, restless legs, difficulty entering sleep, amnesia, myoclonus, hypersensitivity, fecal incontinence. Frequency not known: Shortness of breath during sleep, decreased breathing depth or rate, suicidal thoughts, delusions, convulsions, irritability, aggression, intention to commit violent acts, psychosis euphoria, bipolar disorder, panic attacks, mania. Dehydration, dry mouth, increased libido, urticaria, angioedema, anaphylaxis, dysuria, urgency, nocturia. The drug should be stopped when detecting the above symptoms or other abnormalities after taking Xywav and promptly inform the treating doctor about the use of Xywav or immediately go to the nearest medical facility for timely treatment. .
Note the use of Xywav medicine in the following subjects:
Use caution when using Xywav in people with respiratory or lung problems, cardiovascular diseases such as heart failure, hypertension, impaired liver function kidney. The patient has a history of or is currently suffering from depression, psychosis, bipolar disorder, suicidal thoughts, high anxiety. The patient is sensitive to high levels of sodium in the blood. Pregnancy: Current studies do not clearly understand the risks or harms of using Xywav in pregnant women. Therefore, the use of Xywav in this subject should be considered with caution. Lactation: Studies suggest that the active ingredients Calcium oxybate, Magnesium oxybate, Potassium oxybate and Sodium oxybate found in Xywav can pass into breast milk. Therefore, the use of Xywav on this subject should only be considered if the potential benefit outweighs the possible harm. Drivers or machine operators may experience side effects such as disorientation, dizziness, vision loss, headache, etc., after using Xywav, so it is not recommended to use Xywav. Xywav drugs before entering during work.
6. Xywav drug interactions
Interactions with other drugs:
The use of Xywav is contraindicated with sedative drugs such as Lorazepam, or alcohol because it may increase unwanted side effects. Avoid using Xywav with Tramadol as it can cause depression or respiratory depression. Tricyclic antidepressants increase the CNS depressant effects of Xywav. Reduce the initial dose of Xywav when co-administered with sodium divalproex. Using high doses of Xywav with a GHB Dehydrogenase inhibitor caused more severe impairment in some tests of attention and working memory in clinical studies. Drugs that do not affect the effect of Xywav: Modafinil, Omeprazol, Ibuprofen, Diclofenac. Above is the necessary information about the composition, indications, contraindications, dosage and unwanted effects of Xywav. Patients and family members should carefully read the instructions on the packaging of Xywav and consult with their doctor/pharmacist before deciding to use it.
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