Uses of Xolair

This is an automatically translated article.

1. What is Xolair?

Xolair medicine has the main ingredient Omalizumab with a strength of 150mg. Xolair is a product of Novartis Pharma AG (Switzerland), registered for circulation in Vietnam with registration number VN1-595-11.
Xolair medicine is prepared in powder form and solvent for injection, each box includes 1 bottle of 150mg powder and 1 tube of 2ml solvent.
Omalizumab is a man-made antibody, originally researched and formulated with the aim of reducing sensitivity to allergens when inhaled or swallowed, especially in the management of allergic asthma. severely unresponsive to high-dose corticosteroids.
The mechanism of action of Omalizumab in Xolair is to suppress the immune system's response to an allergic reaction that can lead to an acute asthma attack or skin rash. This effect on the immune system of Xolair ensures a more clear airway of the patient and over time will support better asthma control. For chronic idiopathic urticaria, Xolair is effective in reducing itching and reducing the number of rashes on the patient's skin.

2. Indications and contraindications of Xolair

Novartis Xolair products are indicated in the following cases:
Treatment of moderate and severe asthma in patients over 12 years of age; Treatment of chronic idiopathic urticaria in patients who remain symptomatic despite the use of H1 antihistamines. However, patients with a history of allergies or severe hypersensitivity to Omalizumab should not use Xolair.

3. Dosage, how to use Xolair

Dosage of Xolair drug to treat allergic asthma:
Indication of patients with moderate to severe asthma who have a positive allergy test result or an in vitro reaction to aeroallergen, and symptoms do not adequately controlled with inhaled corticosteroids; The recommended dose is 150-300mg (1-2 vials of Xolair) subcutaneously every 4 weeks or 225-375mg subcutaneously every 2 weeks, depending on pretreatment IgE levels and body weight. of the patient; Before taking Xolair and periodically during treatment, the doctor needs to determine the correct dose and frequency of administration for each patient according to blood IgE levels and body weight. Dosage of Xolair drug to treat chronic idiopathic urticaria:
Xolair is only indicated for patients with chronic idiopathic urticaria who are still symptomatic despite using H1 antihistamines; The recommended dose is 150-300mg (1-2 vials of Xolair) subcutaneously every 4 weeks; Note that the dose of Xolair in patients with chronic idiopathic urticaria is independent of blood IgE levels or patient weight; The duration of treatment for chronic idiopathic urticaria with Xolair has not been established, so the physician should periodically evaluate the drug to consider whether to continue the drug or not. Some notes on the use of Xolair:
Xolair is not indicated for the treatment of allergic conditions or other forms of urticaria; Do not use Xolair for the purpose of relieving acute bronchospasm or for the treatment of malignant asthma. How to use Xolair:
Reconstitute the vial of Xolair powder with 1.4ml of included solvent to obtain a 150mg /1.2mL solution by following these steps: Place the Xolair powder vial upright on a flat surface, then apply aseptic technique to inject the diluent into the powder vial; Holding the vial upright, gently rotate it vertically for about 1 minute so that the solvent evenly wets the powder; Then gently rotate the vial every 5-10 seconds for 5 minutes so that the Xolair powder is completely dissolved; The reconstituted drug solution will be clear or slightly cloudy, which is acceptable if there are a few small bubbles or foam around the edge of the vial; The reconstituted solution of Xolair is slightly viscous so subcutaneous injection may take 5-10 seconds; Do not inject more than 1 vial of Xolair (150mg) at each injection site. When the dose is greater than 150mg, Xolair should be injected at two different sites.

4. Xolair side effects

Common side effects when using Xolair include:
The injection site is red, swollen, burning with pain, bruising, swelling or itching; Joint pain, pain in hands and feet; Tired; Ear hurt. Omalizumab may increase your risk of developing cancer, including breast cancer, skin cancer, salivary gland cancer, and prostate cancer. Therefore, patients should discuss with their doctor about the possible risks of Xolair treatment.
In addition to the side effects mentioned above, Xolair can cause other side effects. Please contact your doctor if you have any unusual problems while taking Xolair.

5. Xolair . Drug Interactions

Drug interaction studies of the active ingredient Omalizumab for injection have not been conducted. Concomitant use of Xolair with other asthma medications may lead to adverse drug interactions. Therefore, patients should consult their doctor for complete advice.

6. Be careful when using Xolair

Before using Xolair, patients should inform their doctor or pharmacist of a history of allergy to Omalizumab or any other allergic condition. Also talk to your doctor about the list of medications you are taking and your medical history.
Pregnant patients should take Xolair only when clearly needed and need to discuss the risks and benefits with their doctor. It is not known whether Omalizumab is excreted in human milk, so nursing patients should consult their doctor about the use of Xolair.
Xolair medicine has the main ingredient Omalizumab with a strength of 150mg. It is used in the treatment of bronchial asthma and chronic idiopathic urticaria in patients who remain symptomatic despite the use of H1 antihistamines. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor and medical staff.
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