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Xelstrym is a prescription medication used to treat the symptoms of attention deficit hyperactivity disorder. Xelstrym can be used alone or with other medicines. This is the first and only transdermal Amphetamine patch approved by the FDA.
1. What is Xelstrym?
What is Xelstrym? Xelstrym contains Dextroamphetamine, the first and only transdermal Amphetamine patch approved by the FDA for once-daily use. Uses of Xelstrym: this is a central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) in adults and children 6 years of age and older. Xelstrym may help increase attention, reduce impulsivity, and hyperactivity in adults and children 6 years of age and older with ADHD. To date, it is not known whether this Xelstrym drug is safe and effective in children younger than 6 years of age.
Dosage form and strength: Xelstrym is a transparent transdermal system with a printed back and a release liner on the other in 4 strengths:
4.5 mg Dextroamphetamine/9 hours; 9 mg Dextroamphetamine/9 hours; 13.5 mg Dextroamphetamine/9 hours; 18 mg of Dextroamphetamine / 9 hours.
2. Instructions for using Xelstrym
Assess the risk of abuse before prescribing and monitor for signs of drug abuse and dependence during treatment. The recommended dose of Xelstrym is:
Pediatric patients 6 - 17 years of age: The recommended starting dose of Xelstrym in pediatric patients 6 - 17 years of age is 4.5 mg every 9 hours. Dosage of Xelstrym may be adjusted in weekly increments of 4.5 mg to a maximum recommended dose of 18 mg every 9 hours. Adults: The recommended starting dose of Xelstrym in adults is 9 mg every 9 hours. Dosage of Xelstrym may be adjusted to a maximum recommended dose of 18 mg every 9 hours. Apply Xelstrym to the treatment site 2 hours before the effect of Xelstrym is needed and remove it within 9 hours of application. Dosage adjustment should be individualized depending on clinical response and tolerability. Long-term treatment with Xelstrym may be required for ADHD and periodic reevaluation of Xelstrym use may be required to adjust dosage as necessary.
Notes in using Xelstrym:
Xelstrym transdermal system should not exceed 9 hours, only use Xelstrym every 24 hours. Apply Xelstrym to cleansed (no cream, oil or gel), dry (not wet) and intact skin at the selected site. Common sites for applying Xelstrym include: hips, upper arms, chest, upper back or side. Avoid touching the sticky side of Xelstrym to avoid absorbing amphetamines. If you touch the sticky side, immediately wash your hands with soap and water. If the Xelstrym patch system peels off at the edges, re-apply the Xelstrym by pressing firmly and swiping down the edges of the patch. If Xelstrym has worn off completely, use a new Xelstrym patch. Xelstrym must not be sealed with gauze, tape, or other common adhesives. Avoid exposing the Xelstrym patch site to direct contact with external heat sources, such as hair dryers, heating pads, electric blankets, hot water beds... Xelstrym handling instructions: After Xelstrym is removed , the used patch must be folded so that its adhesive side adheres to itself, finally put in a covered container, do not flush down the toilet.
3. Xelstrym can cause serious side effects
Abuse and dependence: Xelstrym, other amphetamine-containing products, and methylphenidate are more likely to be abused and can cause physical and psychological dependence. Check for signs of abuse and dependence before and during treatment with Xelstrym.
Heart problems, including:
Sudden death, stroke and heart attack in adults; Sudden death in children with heart problems or heart defects; Increased blood pressure and increased heart rate. Care should be taken to check for heart problems before starting treatment with Xelstrym . Tell your doctor if you have any heart problems, heart defects, high blood pressure, or a family history of these problems. Check your blood pressure and heart rate regularly during Xelstrym treatment.
Mental problems include:
Behavioral and thinking problems tend to get worse; New or worsening bipolar disorder; New psychotic symptoms (such as hearing voices, seeing or believing things that aren't real) or new manic symptoms.
4. Contraindications to the use of Xelstrym
Xelstrym is contraindicated in the following cases:
Allergy to Amphetamine products or any other ingredients. Are taking or have taken within 14 days a monoamine oxidase inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue. Serious side effects of Xelstrym include:
Slowed growth (weight and height) in children. Children should have their height and weight checked regularly during Xelstrym treatment; Circulatory problems in the fingers and toes (peripheral vascular disease, including Raynaud's phenomenon): fingers or toes may feel numb, cool, painful; fingers or toes may change color from pale, to blue, to red; sensitivity to temperature in the fingers or toes; Serotonin syndrome: occurs when Xelstrym is used with certain other medicines with the following signs and symptoms: Agitation; Confused; heart palpitations ; Dizzy; Facial flushing; tremors, muscle stiffness, or muscle twitching; Seeing or hearing things that are not real; Comatose; Changes in blood pressure; Sweat; Increased body temperature; Loss of coordination; Nausea, vomiting, diarrhea; Allergic skin rash (sensitive to contact). Stop using Xelstrym and tell your doctor right away if you have swelling or blistering around the site where Xelstrym was applied (a skin allergy to Xelstrym). People with skin allergies to Xelstrym may be allergic to all products that contain Amphetamine, even Amphetamine products that are taken orally.
5. Notes before using Xelstrym
Before starting treatment, a medical history should be taken of the following:
Heart problems, heart defects or high blood pressure; Psychiatric problems including psychosis, mania, bipolar illness or depression, family history of suicide; Circulatory problems in the fingers and toes; Kidney problems; If you are pregnant or planning to become pregnant, it is not known whether Xelstrym will harm an unborn baby; While breastfeeding, Xelstrym passes into breast milk, so breast-feeding is not recommended during treatment.
6. Drug interactions of Xelstrym
MAOI antidepressants slow the metabolism of amphetamines, while increasing their effects on the release of norepinephrine and other monoamines from adrenergic nerve endings, causing headaches and other signs of a crisis hypertension. Neurotoxic effects and malignant increase in pyrexia, sometimes fatal, may occur. Do not take Xelstrym during or within 14 days after taking an MAOI. Concomitant use of Xelstrym and serotonergic drugs increases the risk of serotonin syndrome. Initiate Xelstrym at a lower dose and monitor the patient for signs and symptoms of serotonin syndrome, especially during initiation of Xelstrym or increasing dose. If serotonin syndrome occurs, discontinue Xelstrym and concomitant serotonergic drug(s); Concomitant use of Xelstrym and CYP2D6 inhibitors may increase the exposure of Xelstrym compared with the use of the drug alone and increase the risk of serotonin syndrome. Initiate Xelstrym at a lower dose and monitor patients for signs and symptoms of serotonin syndrome, especially during the initiation of Xelstrym therapy and after dose increases. Urine alkalinizers can increase blood levels and enhance the action of amphetamines. Concomitant administration of Xelstrym and urine alkalinizing agents should be avoided. Urine acidifiers can decrease blood levels and effectiveness of amphetamines. Increase dose of Xelstrym based on clinical response. Xelstrym is a prescription medication used to treat the symptoms of attention deficit hyperactivity disorder. Xelstrym can be used alone or with other medicines. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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