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Xelostad 10mg drug has the main ingredient is rivaroxaban and is indicated for the prevention of venous thromboembolism in adults undergoing hip or knee replacement surgery, treatment of deep vein thrombosis, pulmonary embolism .
1. What is Xelostad 10?
Xelostad is a drug used to prevent venous thromboembolism in people who have just undergone lower extremity surgery effectively. Patients need to use Xelostad 10 every 6 hours after surgery to achieve good results.
Xelostad 10 drug has the main ingredient is Rivaroxaban 10mg and is made in the form of film-coated tablets.
2. Uses and indications of Xelostad 10
For the most effective use of the drug, patients need to carefully read the instructions for use or follow the instructions of the doctor or pharmacist.
2.1. Indications for Xelostad 10 Thanks to the active ingredients in the drug, Xelostad 10 is indicated for the treatment of the following conditions:
Prevention of venous thromboembolism (VTE) in adults who have undergone hip replacement surgery or knee joint. Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevention of recurrence of DVT and PE in adults. 2.2. Contraindications of Xelostad 10 Xelostad 10 is contraindicated in the following subjects:
Patients with hypersensitivity to the components of the drug. Patients with clinically significant bleeding Patients with lesions or conditions that increase the risk of serious bleeding, such as peptic ulcers, malignancies, and malignancies are at high risk of bleeding. In addition, recently suffered brain damage, spine, brain surgery, spine, eyes, intracranial hemorrhage. In particular, in recent times, there is a suspicion of arteriovenous malformation, esophageal varices, aortic aneurysm,.... The patient is being treated with anticoagulant drugs, except in the following cases. This is particularly the case during anticoagulation transitions or when unfractionated heparin is used in doses necessary to maintain dynamic catheters or open central veins. Patients with liver disease with coagulopathy and at risk of bleeding are associated with patients with Child Pugh B and C cirrhosis. Pregnancy and lactation are contraindicated.
3. Dosage and how to use Xelostad 10
The recommended dose to help prevent venous thromboembolism in major orthopedic surgery is 1 tablet of 10mg/day.
Treatment time
After hip surgery, the patient needs to be treated for 5 weeks. After knee surgery, patients need to be treated for a period of 2 weeks. How to take Xelostad 10 and dose interval:
Patients need to take one 10 mg tablet once daily. Accordingly, you can take it with or without food.
At the starting dose should be used between 6 - 10 hours after surgery, provided hemostasis is established.
4. Notes when using Xelostad 10
In the process of using Xelostad 10, patients should pay attention to some of the following issues:
Do not use Xelostad 10 for patients who are using systemic azole antifungals or anti-inflammatory drugs. HIV inhibits proteases. These drugs are potent inhibitors of CYP 3A4 and P-gp. Therefore, it is possible to increase Xelostad 10 plasma concentrations, increasing the risk of clinical bleeding. The antifungal fluconazole Azole is a moderate CYP3A4 inhibitor. However, the drug has less effect on drug exposure, so it can be used in combination. Pregnancy and breast-feeding: Xelostad 10 is not recommended for use in pregnant and lactating women because the benefits of the drug have not been weighed against the health of the child. Driving and operating machines: Xelostad 10 can cause dizziness, headache. Therefore, patients should not drive or operate machinery if the reaction affects the nervous system.
5. Side effects when using Xelostad 10
During the use of Xelostad 10, patients may experience some unwanted side effects as follows:
Anemia Dizziness, headache; Eye bleeding; Nosebleeds, coughing up blood; Bleeding gums, Gastrointestinal bleeding Gastrointestinal and abdominal pain, indigestion, nausea, constipation, diarrhea, vomiting; Itching Genitourinary tract bleeding Renal failure Fever, peripheral edema, decreased strength and energy Transaminase elevation; Bleeding after the procedure: contusion, secretion of fluid from the incision. In addition to the above side effects, if the patient experiences any side effects, the patient should immediately notify the doctor to promptly adjust the dose and replace other drugs when necessary.
6. Xelostad 10 drug interactions
Do not use Xelostad 10 for patients who are taking systemic azole antifungals or HIV protease inhibitors. Caution should be used in patients receiving concomitant therapy with drugs that affect red blood cells, e.g. non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA), antiplatelet agents, serotonin reuptake inhibitors. selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs).
7. Missed dose and overdose of Xelostad 10 how to handle?
7.1.Treatment of overdose Currently, no side effects have been recorded when using Xelostad 10. and consult your doctor.
7.2. Treatment when missed dose Usually, patients can use the drug in 1-2 hours longer than prescribed by the doctor or prescription. Unless there is a strict rule about the time of use, the patient can take the medicine after a few hours when it is discovered that a dose has been missed. However, if the time to forget Xelostad 10 medicine is too far from the time to take it, the patient should not take the dose of Xelostad 10 again, because it can be dangerous to the body. Accordingly, patients need to strictly follow or consult a doctor before making a decision.
In summary, Xelostad 10mg drug has the main ingredient rivaroxaban and is indicated for the prevention of venous thromboembolism in adults undergoing elective hip or knee replacement surgery, treatment of deep vein thrombosis, Pulmonary embolism. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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