Uses of Vimebulan 500

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1. What is Vinmebulan 500 brand-name drugs?

Vimebulan 500 medicine has the main ingredient of Nabumetone 500mg and other ingredients, just enough for one tablet. Nabumetone is an inactive prodrug that, after being metabolized to 6-MNA (6-methoxy-2-naphthyl acetic acid), is an NSAID (non-steroidal substance), structurally similar to naproxen, with the main action. Pain reliever, anti-inflammatory. The mechanism of action of Vimebulan 500 is similar to that of other substances in the same group, that is, it inhibits the biosynthesis of Prostaglandins, which are mediators of inflammation.
Studies have shown that Vimebulan 500 tends to selectively inhibit COX 2 (Cyclo-Oxygenase 2) enzymes in the inflammatory process more than COX 1 (Cyclo-Oxygenase 1). This helps the drug to be highly effective and cause less side effects on the gastrointestinal tract. The specific effects of Vimebulan 500 are: Antipyretic, analgesic and anti-inflammatory. This drug belongs to the group of non-narcotic pain relievers, used to relieve mild and moderate pain such as pain caused by trauma, menstrual pain, arthritis and other musculoskeletal conditions,...
Indications : Vimebulan 500 used for the symptomatic treatment of the following diseases:
Degenerative joint disease; Rheumatoid arthritis; Ankylosing spondylitis ; Relieve pain caused by trauma, muscle-skeletal pain, menstrual pain. Contraindications : Do not use Vimebulan 500 in the following cases:
People with hypersensitivity to Nabumeton or to any of the ingredients in the drug; People with a history of rhinitis, asthma, angioedema, urticaria or allergy to Ibuprofen, Aspirin or other non-steroidal anti-inflammatory drugs; People with gastric bleeding, gastric ulcer progress; Patients with liver failure, heart failure or severe kidney failure; Women in the last 3 months of pregnancy; Patients with thrombocytopenia, hemophilia.

2. Usage and dosage of Vimebulan 500

How to use: Use Vimebulan 500 by drinking directly, drinking when eating.
Dosage :
For adults: Take 02 tablets/time before going to bed; Severe or prolonged cases or during exacerbations can use 1-2 more pills in the morning; For the elderly: Do not use more than 2 tablets / day, in many cases only 1 tablet is enough; Care should be taken to reduce the dose for patients with renal impairment with creatinine clearance < 30 ml/min. Overdose and treatment:
Symptoms of overdose Vimebulan 500: Headache, epigastric pain, gastrointestinal bleeding, nausea, vomiting. Infrequent cases of diarrhea, irritability, loss of concentration, drowsiness, dizziness, coma, tinnitus, fainting and sometimes convulsions. Severe acute poisoning can damage the liver and kidneys. Treatment: Perform symptomatic treatment, use activated charcoal, in severe cases need to wash the intestines, monitor liver and kidney function, it is necessary to monitor the patient for at least 4 hours. In case the patient has a prolonged convulsion, Diazepam should be injected intravenously and other treatment measures should be applied depending on the clinical condition.

3. Side effects when taking Vimebulan 500

Similar to other non-steroidal anti-inflammatory drugs, Nabumeton also has the following side effects (but the gastrointestinal side effects are usually milder):
On the gastrointestinal tract: Abdominal pain, flatulence, dyspepsia, diarrhea, nausea, vomiting, ... are usually mild and reversible. Rarely, gastric ulcer or gastrointestinal bleeding; On the central nervous system: Dizziness, headache, depression, tinnitus, insomnia, drowsiness; Hypersensitivity reactions include: Fever, angioedema, rash, bronchospasm; Hematology: Anemia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia; On the kidneys: Nephrotic syndrome, interstitial nephritis, renal failure; Some other side effects: Visual disturbances, photosensitivity, alveolitis, pancreatitis, Steven - Johnson syndrome. Patients should pay attention to inform the doctor about unwanted side effects encountered during the use of Vimebulan 500 for appropriate intervention.

4. Be careful when using Vimebulan 500

Attention to caution before and while using Vimebulan 500:
Should use the lowest effective dose in the shortest time to avoid the risk of unpredictable side effects; Use the drug with caution in patients with a history of bronchial asthma; Use the drug with caution in patients with heart failure, liver failure, kidney failure and subjects taking diuretics, the elderly; Attention should be carefully monitored when using Vimebulan 500 for people with a history of hypertension, mild and moderate congestive heart failure because of the risk of fluid retention and edema when using non-steroidal anti-inflammatory drugs; Safety and effectiveness when using Vimebulan 500 for children have not been established, so it should be noted with this subject; Care should be taken to carefully weigh the benefits - risks when using Vimebulan for pregnant women in the first 3 months and in the middle of pregnancy. The use of this drug is contraindicated in the last 3 months of pregnancy. Avoid using the drug for women during lactation; Use Vimebulan 500 with caution when driving or operating machinery because this medicine may cause dizziness in some patients.

5. Vimebulan 500 . drug interactions

Drug interactions can increase adverse side effects or affect the action/effectiveness of many different drugs. It is important to note the interaction of Vimebulan 500 with other drugs:
Nabumeton increases the effect of anticoagulants such as Warfarin; Using Nabumeton with Lithium can cause Lithium toxicity by increasing the concentration of Lithium in the blood; Vimebulan 500 reduces the elimination of Methotrexate; Nabumeton causes increased nephrotoxicity of drugs Tacrolimus, Cyclosporine; Nabumeton increases the hematological toxicity of Zidovudine; The combination of Vimebulan 500 with other non-steroidal anti-inflammatory drugs or with corticosteroids is likely to increase the side effects of the drug; Using Vimebulan 500 at the same time as the antibiotic quinolone may increase the risk of convulsions; Drinking alcohol while using Nabumeton may increase the risk of peptic ulcers; Note that Nabumeton should be discontinued at least 2 days before elective surgery. In the process of using Vimebulan 500, patients and their families should pay attention to strictly follow the doctor's instructions, carefully read the instructions before use to achieve high treatment efficiency, and at the same time, dangerous side effects.
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