Oxaprozin: Uses, indications and cautions when using

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NSAIDs are a group of pain relievers, anti-inflammatory drugs that are widely used today. There are many different active ingredients in this group of drugs and one of them is the drug Oxaprozin. So what effect does Oxaprozin have and what problems should be noted when using it?

1. What does Oxaprozin do?

Oxaprozin is a medicine used to treat arthritis, to reduce swelling, pain, and stiffness. Oxaprozin belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). If you are being treated for a chronic condition such as arthritis, you should talk to your doctor about non-pharmacological treatments and/or the use of other medications to treat pain.

2. How to use Oxaprozin

Read and learn the instructions for use provided by your pharmacist before you start taking Oxaprozin . If you have any questions about Oxaprozin, ask your doctor or pharmacist.
Oxaprozin is to be taken by mouth as directed by your doctor, usually once daily and should be taken with plenty of water (about 240 ml) unless directed otherwise by your doctor. Patients should not lie down for about 10 minutes after taking Oxaprozin. In case of stomach pain while using Oxaprozin, the patient should take the drug with food, milk or take antacids. The dose of Oxaprozin is indicated based on the degree of joint pain, swelling, body weight and the individual patient's response to the drug. The manufacturer recommends a maximum adult dosage of 1,800 mg or 26 mg/kg body weight per day.
To reduce the risk of side effects (such as stomach bleeding), use Oxaprozin at the lowest effective dose for the shortest time possible. Absolutely do not arbitrarily increase the dose of Oxaprozin or use it more times a day than directed. For chronic conditions like arthritis, patients need to carefully follow their doctor's instructions.
In certain conditions (such as arthritis), Oxaprozin may take up to 2 weeks of continuous use for patients to see full effects.

3. Oxaprozin side effects

Nonsteroidal anti-inflammatory drugs (including oxaprozin) may increase the risk of acute coronary artery disease or stroke, which can occur at any time, but the risk is higher if the patient has been taking the drug during long time.
Higher risk is common in older adults or people with a history of heart disease or cardiovascular risk factors (eg, smoking, family history of cardiovascular disease, high blood pressure or diabetes) ). Another important note is that patients should not take Oxaprozin immediately before or after coronary bypass surgery (CABG). In addition, Oxaprozin can cause serious bleeding in the stomach or intestines. This undesirable effect can occur without warning symptoms at any time while taking Oxaprozin . Elderly people are more susceptible to this serious side effect of Oxaprozin .
Stop using oxaprozin and get medical help right away if a patient notices any of the following rare but serious side effects:
Bloody or black/tarry stools; Persistent epigastric or abdominal pain; Vomiting vomit that looks like coffee grounds; Severe pain in the chest behind the sternum; Shortness of breath; Unusual sweating, weakness on one side of the body, sudden vision changes, difficulty speaking. Some other common side effects of Oxaprozin:
Abdominal discomfort; Constipation ; Diarrhea ; Nausea, vomiting; Flatulence, heartburn; Sleepy; Dizziness or headache. Remember that the doctor prescribed Oxaprozin because they judged the benefit to the patient to outweigh the risk of side effects. Oxaprozin can raise your blood pressure, so check your blood pressure regularly and let your doctor know if the results are unusually high.
Some other serious side effects of Oxaprozin include:
Changes in vision; Hearing changes (such as tinnitus); Mental/mood changes; Persistent or severe headache; Unexplained stiff neck; Signs of kidney problems; Easy bruising/bleeding; Symptoms of heart failure (such as ankle/feet swelling, fatigue, unusual/sudden weight gain). Oxaprozin can cause serious (possibly fatal) liver disease. Get medical help right away if patient has any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, severe abdominal pain, yellowing eyes/skin .
Serious allergic drug reactions to Oxaprozin are very rare. However, if the patient has signs such as rash, itching and swelling (especially of the face/tongue/throat), dizziness, trouble breathing... while taking Oxaprozin, call your doctor immediately for treatment. mind. In addition to the side effects listed above, please talk to your doctor or pharmacist if you have any other unusual signs while using Oxaprozin.

4. Notes when using Oxaprozin

Before taking oxaprozin, patients should talk to their doctor or pharmacist about any allergies to the drug, the use of aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib) and the precautions to take. any other allergic condition. Oxaprozin products also contain inactive ingredients and may cause allergic reactions or other problems in some people.
Before using Oxaprozin, please talk to your doctor about your medical history, especially:
Asthma (including a history of shortness of breath after taking aspirin or other NSAIDs); Liver failure; Diseases of the stomach/intestines/esophagus (such as bleeding, ulcers, heartburn); Cardiovascular disease (such as a history of myocardial infarction); Hypertension; Stroke; Blood disorders (such as anemia, bleeding/clotting problems); Tumors in the nose (nasal polyps). Renal abnormalities may occur with the use of NSAIDs, including oxaprozin. This is especially likely if the patient is dehydrated, has heart failure, has pre-existing kidney disease, is elderly, or is taking certain medications. Therefore, the patient should drink plenty of fluids as directed by the doctor to prevent dehydration and notify the doctor immediately if there is a change in the amount of urine.
Oxaprozin can cause stomach bleeding. Other factors such as daily alcohol and tobacco use, especially when combined with Oxaprozin, can increase the risk of stomach bleeding. Therefore, patients should limit alcohol and stop smoking during treatment with Oxaprozin.
Oxaprozin makes the patient's skin more sensitive to the sun, so patients should limit time in the sun, use sunscreen when going out.
Older adults are at a higher risk of side effects such as stomach/intestinal bleeding, kidney problems, heart attack and stroke when using Oxaprozin. Before using Oxaprozin, women of childbearing age should talk to their doctor about the benefits and risks, and tell the doctor if the patient is pregnant, plans to become pregnant, or suspects pregnancy. Oxaprozin can harm an unborn baby and cause problems with normal delivery. Therefore, it is not recommended for use during pregnancy from 20 weeks until delivery. If the physician decides to administer Oxaprozin between the 20th and 30th weeks of pregnancy, the patient should use the lowest effective dose of Oxaprozin for the shortest possible duration of treatment. Absolutely do not use Oxaprozin after the 30th week of pregnancy. Oxaprozin's ability to pass into breast milk is unknown so consult your doctor before breast-feeding.

5. Oxaprozin drug interactions

Drug interactions can change the way Oxaprozin works or increase your risk of serious side effects. Patients should inform their doctor or pharmacist of a list of all the products they are taking with Oxaprozin. At the same time, during the use of Oxaprozin, patients should not arbitrarily start, stop or change the dose of any medicine without consulting their doctor.
Some products that may interact with Oxaprozin include:
Aliskiren; ACE inhibitors (such as captopril, lisinopril); Angiotensin II receptor blockers (losartan, valsartan...); Cidofovir; Lithium; Methotrexate; Diuretics such as furosemide. Oxaprozin may increase the risk of bleeding when taken with other medicines that can also cause bleeding. For example: antiplatelet drugs like clopidogrel, anticoagulants like dabigatran/enoxaparin/warfarin...
Double check all ingredients of prescription and nonprescription medicines as many drugs contain reducing ingredients. pain/fever reducer (eg aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac). These active ingredients are similar to oxaprozin and may increase the risk of side effects if taken together. However, if a patient has been instructed by their doctor to take low-dose aspirin to prevent a heart attack or stroke (usually 81-162mg per day) they should continue to take aspirin unless the doctor instructs otherwise.
Oxaprozin products may interfere with certain laboratory tests, possibly causing false test results. Make sure that the laboratory technician and all the doctors know that the patient is taking Oxaprozin. Symptoms of an Oxaprozin overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, loss of consciousness, slow or shallow breathing.
Laboratory tests and/or medical exams (such as blood pressure measurement, complete blood count, kidney and liver function tests) may be performed periodically to monitor progress develop disease or detect side effects of Oxaprozin .
Non-pharmacological treatment of arthritis (such as weight control, strengthening and conditioning exercises) can help improve the patient's flexibility, range of motion, and joint function. Store Oxaprozin at room temperature, away from light, moisture, away from children and pets. Do not flush Oxaprozin down the toilet or down the drain unless it has expired or is no longer needed.
Above is important information about Oxaprozin drug, patients need to pay attention and consult carefully with doctors and pharmacists before taking the drug to promote the best effect in treatment.
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Reference source: webmd.com