Uses of Vialexin 500

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1. Effects of Vialexin 500

Vialexin 500 medicine contains the active ingredient Cephalexin 500mg as the main ingredient. Vialexin 500 has a medium spectrum of activity, active against gram-positive bacteria such as streptococci, staphylococci, and pneumococcus, except for methicillin-resistant streptococci. Acts on some gram-negative bacteria such as E. coli, Proteus mirabilis, Klebsiella pneumoniae and Shigella. There are also other strains such as: Enterobacter, Bacteroid, Enterococcus, ...
Vialexin 500 is indicated for use in the following cases:
Used in respiratory tract infections such as: bronchiectasis with multiple infection, acute and chronic bronchitis. Treatment in ear, nose and throat infections: sinusitis, otitis media, mastitis, pharyngitis. Treatment of urinary tract infections: cystitis, acute and chronic pyelonephritis, prostatitis and prophylaxis in recurrent urinary tract infections. Indicated for use in patients with infections of obstetrics and gynecology, soft tissue, skin and bone, syphilis and gonorrhea (when the patient has used penicillin but is not suitable), temporary replacement of preventive therapy with Penicillin antibiotics for dental patients who have heart disease and need dental treatment. It is also used to treat infections caused by a number of other gram-positive and gram-negative bacteria. Do not use for patients with hypersensitivity to any ingredient of Vialexin 500, active ingredient Cephalexin (Cephalosporin antibiotics). Patients with a history of anaphylaxis due to penicillin use or other severe IgE immune globulin-mediated reactions.

2. Usage and dosage of Vialexin 500

2.1. How to take Vialexin 500 is used orally, should be taken on an empty stomach and preferably about 1 hour before eating.
2.2. Dosage The majority of infections in adults will respond to oral doses of 1 to 2 g of Vialexin 500 per day in divided doses. For most infections, the following doses can be used:
For adults:
Take a dose of 500mg 3 times a day. In case of severe infection or deep localization, especially less susceptible bacteria, it is necessary to increase the dose by 1g x 3 times a day or 1.5g x 4 times a day. For the prevention of recurrent urinary tract infections, the recommended dose of 125 mg can be given at each evening meal and for several months continuously. If you are on intermittent dialysis, 500 mg of Vialexin 500 should be administered after each dialysis session, with a maximum total dose of 1 g on that day. For children:
For children, the dose should be calculated based on body weight, especially for young children. Recommendations may be based on dosages of 25 to 60 mg/kg body weight/day. For children with chronic infections or serious infections, deep localized, the dose should be increased to 100 mg/kg body weight/day and used for a maximum of 4 days. Children over 12 years old: take 3 times a day, 500mg once a day. Children from 5 to 12 years old: 3 times a day, 1 time 250mg. Children from 1 to 5 years old: 3 times a day, 1 time 125mg. Children < 1 year old: 2 times a day, 1 time 125mg. When the child is on intermittent dialysis, Vialexin 500 should be supplemented at a dose of 8 mg/kg body weight. Note: In most acute infections, when symptoms subside and signs return to normal, the patient should be continued for at least 2 more days with Vialexin 500.
But in complicated syphilis and recurrent or chronic urinary tract infections, it is recommended to treat for 2 weeks, 4 times a day, 1 time 500mg. Although up to now Cephalexin has not been shown to have nephrotoxicity, however, Cephalexin is eliminated mainly by the kidneys, which can cause unnecessary accumulation when renal function is reduced by more than half of normal. often. The recommended maximum dose reduction to suit these subjects is 4g daily for children and 6g for adults.

3. Vialexin 500 . drug interactions

Concomitant use of high doses of Vialexin 500 with strong diuretics or Aminoglycosides may affect the kidney function of the patient. When the patient is using oral contraceptives, Vialexin 500 can reduce the effect of estrogen in the drug leading to a decrease in contraceptive effectiveness. When Cholestyramine and Cephalexin are used at the same time, they will bind together in the intestines, reducing the absorption of each other. For Cephalexin, serum concentrations and half-life were increased and renal excretion was decreased when Vialexin 500 was co-administered with Probenecid. The effect of Metformin is increased, but the effectiveness of the typhoid vaccine is decreased when co-administered with Vialexin 500. Uricinogenic agents increase the effect of Cephalexin in Vialexin 500.

4. Undesirable effects

When patients use Vialexin 500, may experience side effects such as: gastrointestinal disorders (vomiting, nausea, diarrhea, loss of appetite, dyspepsia, abdominal pain, epigastric discomfort), rarely allergic reactions, angioedema, eosinophilia, reversible neutropenia, anaphylaxis, pseudomembranous colitis, superinfection, urticaria, drug rash... In children Small children when using Vialexin 500 can change behavior behavior, deafness, dizziness, tinnitus. Like other broad-spectrum antibiotics, Vialexin 500 can cause growth of symbiotic bacteria that cause vulvar itching, vaginitis, and genital candidiasis.

5. Pay attention when using Vialexin 500

Patients with renal failure, it is necessary to closely monitor the patient and reduce the therapeutic dose. Causes superinfection of non-susceptible bacterial strains when using the drug for a long time, in addition, it is necessary to check the patient's liver and kidney function, hematopoietic function. Use with caution in patients with colitis or in patients with a history of gastrointestinal disease. Use with caution in pregnant and lactating women because safety has not been established, use only when absolutely necessary, weighing the benefits of treatment against adverse effects.

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