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Usazapine is a medication used to treat moderate to severe depression. It is extremely important and necessary to learn information about the drug before using it, to help users avoid unwanted side effects.
1. What is Usazapine?
Usazapine medicine is a product containing the active ingredient Mirtazapine 30mg. This is an active antidepressant that works by restoring the balance of natural chemicals (neurotransmitters) in the human brain.
2. Indications and contraindications Usazapine
2.1. Indications Usazapin is used for people with depression, to help improve mood and enhance health for users. In addition, Usazapine is also used in the treatment of a number of other conditions when prescribed by a doctor.
2.2. Contraindications Usazapine is contraindicated in patients with a history of hypersensitivity to the active ingredient mirtazapine or who have used a monoamine oxidase inhibitor (MAOI) within the previous 10 days.
3. Dosage and how to use Usazapine drug
3.1. Usazapine dosage used for adults with reference dosage is as follows:
Patients with major depression use the drug with a starting dose of 15mg/day, in the absence of a clear clinical response, the dose can be increased. up to 45 mg/day. However, dose increases need to be kept at least 1-2 weeks apart due to the long half-life of the drug. The maximum duration of drug use has not been clearly established. Essentially, treatment should be maintained for at least 6 months for an acute depressive episode. Then, when the disease improves, the patient should gradually reduce the dose before stopping the drug to avoid withdrawal syndrome. In patients with hepatic and renal impairment, a dose reduction should be considered in patients with hepatic impairment (clearance of the active ingredient mirtazapine is reduced by 30%) and in patients with renal impairment (the clearance of the active substance mirtazapine is reduced by 30 - 50%). . 3.2. Usazapine is recommended to use 1 time before going to bed or divided into 2 times (Take 1 time in the morning and 1 time at night before going to bed).
For the medicine to work, remove the medicine from the package before use. Then, gently place the medicine on the tongue, dissolve and swallow with saliva. Never use water or other liquid to take the medicine and do not break the Usazapine tablet before taking it.
4. Usazapine side effects
In the process of using Usazapine to treat depression, patients may experience typical side effects such as:
Somnolence, feeling dizzy, easy to sleep with nightmares, confusion, fatigue. Elevated serum cholesterol or in some cases increased serum triglycerides. Vomiting or nausea, loss of appetite, epigastric pain, constipation, dry mouth, cravings, overeating leading to weight gain. Hypertension, vasodilation, peripheral edema, edema, myalgia, back pain, arthralgia, tremor, feeling of limb weakness, dyspnea, urinary frequency. In some cases, rare side effects occurred when taking the drug, such as:
Agranulocytosis, dehydration, increased transaminases, convulsions, torsades de pointes, weight loss, hyponatremia. Patients may also have neutropenia, orthostatic hypotension, and extrapyramidal syndrome.
5. Usazapine drug interactions
The active ingredient mirtazapine contained in Usazapine may enhance the CNS depressant effects of alcohol. Therefore, the patient absolutely should not drink alcohol during treatment with the drug.
Do not use Usazapine concurrently with MAO inhibitors or within 2 weeks of discontinuing treatment with these drugs.
Usazapine will increase the sedative effect of benzodiazepines, caution should be taken when using 2 drugs at the same time.
6. Precautions when using Usazapine
Use caution when administering Usazapine to persons under 18 years of age due to an increased risk of suicide or hostile behaviour. Use caution when using the drug in patients with coronary artery disease, cerebrovascular disease or other diseases because it will cause orthostatic hypotension. With caution in patients with hepatic impairment, moderate and severe renal impairment, the drug should be discontinued if signs of jaundice appear. After discontinuing Usazapine, patients should rest for 2 weeks before starting monoamino oxidase inhibitor (MAO) therapy to avoid serotonin syndrome. Usazapine should be used with caution in patients with a history of mania or hypomania, due to the risk of triggering these states shortly after administration. Caution should be exercised in patients with a history of seizures, urinary disturbances, open-angle glaucoma or glaucoma. If fever, sore throat, stomatitis or other symptoms of infection appear while taking the drug, the patient should immediately discontinue use and have a complete blood count test to check the condition. In the initial stage of treatment with Usazapine, patients will feel dizzy, so patients should avoid driving and operating machinery during this period. Do not use the drug for pregnant women, those who are breastfeeding unless directed by a doctor to protect the health of mother and baby. Above is some information you need to know about Usazapine. This is a prescription drug, only used for a few subjects, so patients need to strictly follow the instructions from the doctor to achieve the best treatment effect.
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