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Usarvudin – prescription anti-infective, antiviral drug. Let's find out more about what is Usarvudin? What diseases does Usarvudin treat, how to use it, how to use Usarvudin? ... right in the following article.1. What is Usarvudine?
Usarvudin is a prescription drug that belongs to the list of antiviral and antiparasitic drugs. Usarvudin drug is manufactured by Branch of Phong Phu Pharmaceutical Joint Stock Company- Usarichpharm pharmaceutical factory - VIETNAM. Registration number VD - 30204 - 18.
The main ingredient in Usarvudin is the active ingredient Lamivudin 100mg with excipients. Usarvudin drug is prepared in the form of film-coated tablets, white and red box with the name of the drug, ingredients printed in black, content in red.
2. Uses of the drug Usarvudine
Usarvudine is a prescription drug. The active ingredient Lamivudin in the drug has a highly active antiviral effect on hepatitis B virus. In particular, this active substance is active against all cell lines tested when infected with hepatitis B.
Active ingredient Lamivudin is metabolized by both infected and uninfected cells to a triphosphate derivative (TP). The intracellular half-life of TP in the liver is 17-19 hours in vitro.
Lamivudin - TP itself is likened to a substrate for the polymerases of the HBV virus - hepatitis B virus. The subsequent appearance of HBV DNA is blocked by the ability of Lamivudin - TP to merge into the chain. and lead to thread termination.
Lamivudin – TP does not interfere with Desoxynucleotid metabolism in healthy cells. It is only a weak inhibitor of alpha and beta DNA polymerases.
Usarvudine is absorbed from the gastrointestinal tract, excreted unchanged by the kidneys. Elimination time is 5-7 hours.
In general, the drug Usarvudin with the active ingredient Lamivudin after entering the body will be converted into the active form TP. At this time, the drug has the effect of stopping and stopping the DNA replication process of the hepatitis B virus. Thereby, preventing the rapid growth of the virus in the body.
3. Indications for use of the drug Usarvudin
Usarvudin is used in the following cases:
Hepatitis B; Compensated liver disease; Decompensated liver disease; Cirrhosis ; Immunodeficiency ; Liver transplant. Use Usarvudine safely when directed by your doctor.
4. Dosage, how to use the drug Usarvudin
To ensure the effectiveness of using Usarvudin, you need to use the drug correctly, at the right dose according to the instructions of the medical staff.
How to use Usarvudin:
Because Usarvudin is made in the form of film-coated tablets, the way to use it is to take it directly. This is a drug for hepatitis B, but when used, it must be prescribed by a doctor. There was a transformation of HbsAg or HBeAg in subjects with normal immune systems. If treated with Usarvudine, the serum ALT level does not change compared to before taking the drug. This shows that Usarvudin has no effect. In the group of subjects with hepatic impairment, no dose adjustment is required, except for those with concomitant renal failure. You can take Usarvudine during or after eating. However, when taking Usarvudin, swallow the tablet whole, do not crush or chew the medicine. Dosage of Usarvudine
According to the manufacturer's recommendations, you can take a dose of 100mg/day for people > 16 years old. In addition, in the group of subjects with renal failure, if the creatinine clearance rate is less than 50ml/min, the dose should be adjusted down according to the instructions.
Besides, for the group of subjects on HIV treatment in combination with Zidovudine, the dose is as follows:
Adults take the recommended dose of 150mg/time x 2 times/day. In addition, add Zidovudin 600mg daily x 2-3 times/day; Dosage for children is 4mg/kg body weight/time divided into 2 times/day. However, the maximum use is only 300mg / day in combination with Zidovudin 360 - 720mg / day divided into several times. Adjust dose for patients with renal impairment when creatinine clearance <30ml/min.
5. Contraindications to using the drug Usarvudine
Usarvudin drug is not used for people who are hypersensitive or allergic to Lamivudin. In addition, Usarvudin is also contraindicated when combined with Retroviral drugs for the following subjects:
Kidney disease with creatinine clearance ≤ 50ml/min; Liver failure. To use the drug safely, be careful not to use Usarvudin for the contraindicated group.
6. Usarvudine side effects
Usarvudine can cause side effects including:
Vomiting; Nausea; Abdominal discomfort; Flatulence; Diarrhea; Inflammation of the respiratory tract; Headache; Tired; Steatosis ; Virus strain mutation; Drug resistance; Pancreatitis. The side effects when taking Usarvudine are quite complicated. Please notify your doctor when experiencing clinical manifestations that are thought to be side effects after taking Usarvudin for timely and accurate treatment.
7. Interactions with other drugs
When taking Usarvudine, there may also be interactions with other drugs. Some cautions about Usarvudine drug interactions include:
Anti-UTI trimethoprim; HIV medicine; Ganciclovir. To be safe, reduce side effects and interactions when taking Usarvudin, tell your doctor about all the medicines you are taking.
8. Warnings and Precautions for Usarvudin
Some warnings and cautions given by the manufacturer when using Usarvudin include:
Subjects with fatty liver, hepatomegaly, ... when using Usarvudin must be cautious; Usarvudine is not used for patients with both hepatitis B and HIV; After stopping treatment with Usarvudine you may become infected again and the condition may be worse in subjects with uncompensated hepatitis. Therefore, it is necessary to monitor and evaluate function within 4 weeks after stopping the drug; Use caution in children under 2 years old, people infected with both hepatitis B and hepatitis C at the same time, HIV infection, liver transplant... Pregnant and lactating women only use Usarvudin when absolutely necessary and must have instructions, instructions from the doctor; Comply with the indications for the dose of Usarvudine; When stopping Usarvudine, there must be instructions and prescriptions from your doctor. These warnings from the manufacturer are given to ensure safe use of the drug.
In summary, Usarvudin is a medicine for hepatitis B. Usarvudin belongs to the group of drugs prescribed by a doctor/pharmacist. If you have any questions about taking medicine, you can contact your healthcare provider for further answers.
