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Ursopa is indicated in the treatment of primary biliary cirrhosis, cholesterol gallstones... Let's learn about the uses and notes when using Ursopa through the article below.
1. Uses of Ursopa
“What does Ursopa do?” Ursopa medicine contains active ingredient Ursodeoxycholic Acid 500mg in the form of film-coated tablets.
Active ingredient Ursodeoxycholic Acid 500mg is a natural bile salt with low content in the body, hydrophilic properties and no cleansing effect. Ursodeoxycholic Acid acts on the enterohepatic cycle of endogenous bile acids, reducing the reabsorption of bile through active inhibition of intestinal reabsorption, increasing bile secretion, thereby reducing the concentration of endogenous bile acids. in blood. Urodeoxycholic acid is used in the treatment of gallstones by reducing the concentration of cholesterol in bile. This effect is through the following mechanism: Increase cholesterol metabolism in the liver, reduce cholesterol absorption, maintain cholesterol in soluble form in bile.
Ursopa drug is indicated in the following cases:
Treatment of cholesterol gallstones: Small gallstones less than 15mm in diameter, asymptomatic gallstones, no contrast, gallbladder still functioning normally in humans. disease with stones but contraindications to surgery; Treatment of chronic hepatobiliary disease, especially primary biliary cirrhosis, liver disease caused by viscous mucus disease, sclerosing cholangitis.
2. Dosage of Ursopa
Ursopa belongs to the group of prescription drugs, the dose of medicine used is prescribed by the treating doctor based on the patient's condition. Ursopa is taken orally.
Some recommendations on Ursopa dosage in adults are as follows:
Prevention of gallstones: Take 300mg/time x 2 times/day; Treatment to dissolve gallstones: Take 8-12mg/kg/day divided into 2 times; Treatment of primary biliary cirrhosis: Take 10-15mg/kg/day divided into 2 oral doses; Treatment of cholesterol gallstones: The effective dose is from 5 to 10mg/kg/day, the average recommended is 7.5mg/kg/day in patients of average condition. For obese patients, the recommended dose is 10mg/kg/day.; Treatment of chronic hepatobiliary disease: The recommended dose is 13-15mg/kg/day. It is recommended to start at a dose of 200mg/day, increasing the dose in a stepwise manner to reach the optimal dose after 4-8 weeks of treatment. In case of patients with hepatobiliary disease due to viscous mucus disease, the optimal dose should be 20mg/kg/day. Ursopa should be taken in 2 doses in the evening and then with a meal. Patients should adhere to the correct dose and duration of medication prescribed by the doctor.
3. Side effects of Ursopa
Ursopa can cause some unwanted effects as follows:
Common: Allergies, urticaria and itchy skin during the initial treatment; Uncommon: Diarrhea, vomiting, anabolic gallstones, nausea, pasty stools, rash. Patients should inform their doctor about unwanted symptoms encountered during treatment with Ursopa.
4. Note when using Ursopa
4.1. Contraindications Urospa is contraindicated in the following cases:
Patients with hypersensitivity to Ursodeoxycholic Acid or any of its ingredients; Patients with acute bile duct inflammation or cholecystitis; Patients with biliary obstruction; Patients often experience pain due to gallstones; Patients with calcified contrast-enhanced gallstones; Patients with impaired contraction function of the gallbladder; Children under 18 years of age with cystic fibrosis have undergone bile-intestinal bypass surgery but failed. 4.2. Precautions for use For long-term Ursopa therapy, patients should undergo periodic rectal monitoring.
With caution when using Urospa in the treatment of cholesterol gallstones, check the effectiveness of treatment by imaging every 6 months.
In the treatment of chronic hepatobiliary disease:
Patients with cirrhosis associated with cholestasis or hepatocellular impairment, impaired liver function should be carefully monitored; In case of patients with cholestasis causing pruritus, the dose of Ursopa should be gradually increased, starting at 200mg/day. In this case, concomitant use with Cholestyramine is necessary (Cholestyramine must be administered 5 hours apart from Ursodeoxycholic); For pregnant and lactating women: There have been studies demonstrating the possibility of teratogenicity during treatment with Ursodeoxycholic Acid. Therefore, the use of Ursopa is contraindicated in these patients.
5. Drug interactions
Ursopa drug may cause some of the following drug interactions:
Cholestyramine: Concurrent use of Ursodeoxycholic Acid and cholestyramine reduces the effect of Ursodeoxycholic Acid. In case of necessity, these drugs must be taken 5 hours apart; Estrogen-stimulating agents should not be used during treatment with Urospa due to the risk of increased biliary cholesterol; Avoid using Urospa together with other drugs that bind bile acids such as activated charcoal, antacids because it can reduce the therapeutic effect of Urospa. Drug interactions occur that reduce the therapeutic effect of Ursopa, increasing the risk of unwanted effects. Therefore, patients need to inform their doctors about the drugs and supplements they are using before treatment with Urospa to ensure safety and effectiveness during treatment.
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