Uses of Ultibro Breezhaler

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Ultibro Breezhaler is a combination drug between two bronchodilators by different mechanisms, to increase the bronchodilator effect in the treatment of chronic obstructive pulmonary disease. So how is Ultibro Breezhaler used?

1. Uses of Ultibro Breezhaler

Ultibro Breezhaler is a combination medicine with the main active ingredient being Indacaterol (as Indacaterol maleate) 110mcg and Glycopyrronium (as Glycopyrronium bromide) 50mcg.
Among them, Indacaterol is a long-acting beta 2 agonist of the adrenergic system that is administered once a day. Pharmacological effects of beta2-adrenergic receptor agonists. The effect of beta-2 agonists is to increase the concentration of cyclic AMP leading to relaxation of bronchial smooth muscle. In vitro studies have shown that indacaterol has a beta 2 receptor agonist effect 24 times stronger than on beta 1 and 20 times stronger on beta 3 receptors, so it may have selectivity properties. . After inhalation, indacaterol exerts a local effect on the lungs as a long-lasting bronchodilator. Glycopyrronium is a long-acting inhaled (mainly M3) muscarinic receptor antagonist of the anticholinergic class, also used once daily for the maintenance treatment of bronchiectasis in patients with chronic lung disease. congestion. Glycopyrronium inhibits the effect of acetylcholine (this is a bronchoconstrictor on the smooth muscle cells of the airways) thereby dilating the airways.
In Ultibro Breezhaler, a combination of two substances indacaterol and glycopyrronium acts on different receptors of bronchial smooth muscle, thereby giving a synergistic effect to relax smooth muscles. Beta 2 agonists are more effective at dilating the small airways, whereas anticholinergics may be more effective on the larger airways. Therefore, the combination of a beta 2 agonist with an M receptor antagonist may achieve the most optimal bronchodilator effect.
Thanks to its bronchial smooth muscle relaxant effect, Ultibro Breezhaler is indicated for once-daily administration for the maintenance treatment of symptomatic relief and relief of exacerbations in patients with chronic obstructive pulmonary disease (COPD).

2. How to take Ultibro Breezhaler

How to use: Inhale through the mouth with the inhaler that comes with the medicine at the same time of day. Be careful not to swallow the capsule.
Dosage: Adults over 18 years old use once a day. For patients with hepatic impairment, mild and moderate renal impairment, the usual dose can be used. But in severe cases, there is no safety recommendation.

3. Notes when using Ultibro Breezhaler

Do not use the drug for patients with a history of hypersensitivity to the drug or any of its components, children under 18 years of age, and should not be used to treat asthma.
When taking the drug may appear some side effects such as: Cough, sore throat, upper respiratory tract infection, dizziness, headache, indigestion, musculoskeletal pain, fever and chest pain. When taking the drug, there are signs such as difficulty breathing, difficulty swallowing, swelling of the tongue, swelling of the lips and face; hives, rash on the skin; Paradoxical bronchospasm, signs/symptoms of acute angle-closure glaucoma, the drug must be discontinued immediately and medical personnel should be contacted as soon as possible. Cases needing extreme caution when using the drug are patients with urinary retention, coronary heart disease, acute myocardial infarction, arrhythmia, hypertension, epilepsy, thyroid toxicity, diabetes mellitus, Unusual responses to ß2-adrenergic agonists, current MAOIs, tricyclic antidepressants, or other drugs known to prolong the QT interval on the electrocardiogram. Use the medicine according to the dose recommended by your doctor, do not use it more often or at a higher dose than recommended. Drug interactions can occur as with the concomitant use of other sympathomimetic agents, which may increase the adverse effects of indacaterol; Concomitant use with methylxanthine derivatives, steroids, and potassium-sparing diuretics may increase the risk of hypokalemia. For subjects such as pregnant women, lactating women, patients with severe renal impairment, it should only be used if the benefits outweigh the risks. Ultibro Breezhaler is a bronchodilator and is used in patients with COPD. When prescribed to use the drug, you need to follow the doctor's prescription, do not arbitrarily use it, because it can cause many disadvantages to health.
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