Uses of Ukoniq

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1. What is Ukoniq?

Kinase is an enzyme that promotes cell growth, in the body there are many types of kinases, which help control different stages of cell development. By blocking a specific enzyme from working, Ukoniq can slow the growth of cancer cells by inhibiting PI3Kδ and casein kinase CK1ε. The main active ingredient in Ukoniq is Umbralisib. PI3Kδ is expressed in normal and malignant B cells whereas CK1ε has been implicated in the pathogenesis of cancer cells, including lymphoid malignancies. Umbralisib also inhibits a mutated form of ABL1 in biochemical assays.
What does Ukoniq do? Ukoniq is used to treat various types of lymphoma in adults.

2. How to use Ukoniq

Ukoniq is available as a tablet to be taken by mouth, with food at the same time each day. Patients should not crush, break, cut or chew Ukoniq tablets. If a patient vomits after taking a dose of Ukoniq, do not take the Ukoniq dose that day, but take the next dose at the patient's usual time each day. If the patient misses a dose of Ukoniq, take Ukoniq as soon as the patient remembers it on the same day. However, if it has been more than 12 hours, skip that day's dose of Ukoniq and take the next scheduled dose the next day.
It is important to ensure that the patient is taking the correct amount of Ukoniq each time. Before each dose of Ukoniq, check that what the patient is taking matches what the doctor has prescribed. Note that Ukoniq may cause interactions for people who are allergic to FD&C Yellow No. 5 and Aspirin.

3. How is Ukoniq stored?

Store Ukoniq medicine in its original, labeled packaging, store at room temperature and in a dry place, do not store in the medicine box, keep Ukoniq out of the reach of children and pets.
If caregivers are preparing a dose of Ukoniq for a patient, they should consider wearing gloves or pouring the medication directly from the container into the lid, cup, or directly into the patient's hand, avoiding touching the tablet. Always wash your hands before and after administering Ukoniq to a patient. Pregnant or nursing women should not prepare doses of Ukoniq for patients. Do not flush Ukoniq down the toilet or throw it in the trash.

4. Possible side effects of the drug Ukoniq

Patients can apply a number of different measures to control the side effects of Ukoniq for each specific patient. The following are some of the most common or important Ukoniq side effects:
4.1. Kidney problems Ukoniq can cause kidney problems, including increased creatinine levels, which your doctor can monitor using blood tests. Notify physician if patient notices decreased urine output, bloody urine, swollen ankles, or loss of appetite.
4.2. Diarrhea Diarrhea is a possible side effect of Ukoniq due to the risk of dehydration. Your doctor may prescribe certain medications to control this. In addition, the patient can apply some measures such as:
Limit high-fiber foods, so eat light foods such as white rice, boiled chicken; Avoid raw fruits, raw vegetables, whole grain breads, cereals and nuts; Use foods with soluble fiber such as apple sauce, ripe bananas, boiled potatoes, chips, products made with white flour or oatmeal; Drink enough water, limit alcohol or caffeine to prevent dehydration. 4.3. Decreased white blood cells, increased risk of infection Ukoniq medicine can cause life-threatening infections, with or without lowering white blood cell counts. Your doctor may prescribe medication to prevent certain infections from developing associated with this treatment.
White blood cells play a role in fighting infections in the body. During treatment with Ukoniq, white blood cell counts may decrease and lead to an increased risk of infections. It is important that patients taking Ukoniq tell their doctor or nurse immediately if they have signs of an infection such as: fever over 38 degrees, sore throat, cold, trouble breathing, cough, painful urination or other symptoms. slow-healing ulcers.
Some doctor's recommendations to limit infection while taking Ukoniq :
Wash your hands often, including patients, relatives or visitors; Limit going to crowded places or contact with people showing signs of infection (having a cold, fever, cough or living with someone with these symptoms); Do not dispose of pet waste while being treated with Ukoniq ; Keeping open wounds or skin scratches clean; Bathing, body hygiene, dental care regularly; Do not remove corners, cut ingrown fingernails/toenails; Talk to your oncologist before having a dental procedure while taking Ukoniq; Consult your doctor before receiving any vaccine while taking Ukoniq . 4.4. Fatigue even at rest Fatigue is very common during cancer treatment with Ukoniq , Ukoniq users often feel exhausted and not relieved by rest. Therefore, during cancer treatment with Ukoniq and for some time afterward, patients need to adjust their schedule to control fatigue. Besides, proper exercise can also help patients fight fatigue caused by Ukoniq.
4.5. Nausea and/or Vomiting During Ukoniq treatment, additional medications to help control nausea and vomiting can be added along with dietary changes, avoiding things that may worsen vomiting symptoms, such as eating foods that are too thick or very greasy/fat, spicy, or acidic (lemon, tomato, orange).
4.6. Decreased red blood cells increases the risk of anemia for patients Red blood cells play a role in transporting oxygen in the blood to provide tissues in the body, when the number of red blood cells is low, it will cause internal organs deprived of oxygen to function. At this time, symptoms such as: fatigue or lack of energy. Patients should inform their doctor if they have symptoms of anemia such as shortness of breath, fatigue or chest pain... during treatment with this medicine. In some cases the red blood cell count is too low due to Ukoniq which may require a blood transfusion.
4.7. Decrease in the number of platelets in the patient's body Platelets are part of the blood clotting process, when the number of platelets decreases, it leads to the risk of bleeding. If you are taking Ukoniq, tell your doctor if you experience bruising or unusual bleeding (bleeding from the nose or teeth, bloody urine, etc.). Platelet transfusion is necessary if the patient's platelet count is too low while taking Ukoniq. Besides, patients should also avoid some activities that can cause bleeding during treatment with Ukoniq as follows:
Limit or avoid the use of razors; Avoid playing contact sports that have the potential to cause injury or bleeding; Ukoniq should not be used concurrently with Aspirin or non-steroidal anti-inflammatory drugs (NSAIDs); Do not use dental floss, toothpicks; Do not brush your teeth with a brush with too stiff bristles. 4.8. Muscle or joint pain, headaches Your doctor may recommend medications and other strategies to help relieve the pain.
4.9. Electrolyte abnormalities Ukoniq may affect the normal levels of electrolytes (potassium) in a patient's body, which will be monitored with blood tests. If sham electrolyte levels become too low, your doctor may prescribe specific electrolytes to be given intravenously or orally. Do not take any supplements without consulting your doctor.
4.10. Important but less common side effects of Ukoniq Hepatotoxicity: Use of Ukoniq can cause hepatotoxicity, which can therefore be monitored by regular liver function tests by the treating physician. Inform your doctor if you have symptoms of liver toxicity while taking Ukoniq such as jaundice, yellow eyes, dark urine, right upper quadrant abdominal pain... Serious skin reaction: tell your doctor. immediately if the patient develops a new or worsening skin rash with painful sores on the skin, rash, blisters or peeling skin, itching, or fever.

5. How does Ukoniq affect fertility?

Exposing the fetus to Ukoniq drug can lead to birth defects, so patients should not become pregnant or father a child during cancer treatment with Ukoniq. The use of effective birth control or birth control methods is essential, especially during Ukoniq treatment and for at least 1 month after Ukoniq therapy ends. Even if the menstrual cycle stops or the patient believes that he or she is not producing sperm, the ability of both sexes to conceive is still possible. Note that the patient should not breastfeed while taking Ukoniq. Ukoniq drug is prepared in the form of tablets with the content of 200mg Umbralisib. The drug is used to treat all types of lymphoma in adults and should only be used with a doctor's prescription.
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Reference source: oncolink.org