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Turbezid belongs to the group of drugs to treat tuberculosis. Turbezide has three active ingredients: Rifampicin, Isoniazid and Pyrazinamide. This drug is prepared in the form of film-coated tablets, suitable for oral administration.
1. What is Turbezide?
Turbezid drug has the main active ingredient: Rifampicin 150mg, Isoniazid 75mg, Pyrazinamide 400mg and excipients with a sufficient amount of 1 tablet. The drug is in the form of film-coated tablets. Packing specification is a box of 3 blisters, each blister contains 12 tablets.
Effects of each drug in Turbezid:
Rifampicin: Rifampicin is a semi-synthetic antibiotic derivative of Rifampicin B. Rifampicin is active against bacteria of Mycobacterium strains, especially tuberculosis, leprosy and other Mycobacterium such as M. bovis, M. avium. In addition, the active ingredient rifampicin is not cross-resistant with other antibiotics and tuberculosis drugs. Rifampicin inhibits the DNA-dependent RNA synthesis enzyme activity of Mycobacterium and other bacteria by means of drug-enzyme stability. Isoniazid: Isoniazid was one of the first chemotherapy drugs of choice for the treatment of tuberculosis. Highly specific drug, active against Mycobacterium tuberculosis and other atypical Mycobacterium such as M. bovis, M. kansasii. Isoniazid has a bactericidal effect depending on the concentration of the drug at the site of injury and the sensitivity of the bacteria. Pyrazinamide: Pyrazinamide is a multi-drug anti-tuberculosis chemotherapy agent, mainly used during the first 8 weeks of short-term chemotherapy. The active ingredient Pyrazinamide is effective against Mycobacterium tuberculosis but has no effect on other Mycobacterium or other bacteria in vitro. The initial inflammatory response to chemotherapy increases the number of bacteria in the acidic environment. When the inflammatory response decreased and the pH increased, the bactericidal activity of the active ingredient pyrazinamide decreased. The efficacy of the active substance is also dependent on pH to explain the clinical efficacy of the drug during the first 8 weeks of short-term chemotherapy. Mycobacteria rapidly develop drug resistance when pyrazinamide is used alone
2. What disease does Turbezid treat?
Turbezid is used to treat all forms of pulmonary and extrapulmonary tuberculosis in adults.3. Usage and dosage of the drug Turbezid
Dosage of Turbezid drug depends on the body weight of each specific person:
For people under 50kg: use 3 tablets / day. For people over 50kg: use 4 tablets/day. Take Turbezid once in the morning, on an empty stomach.
4. Undesirable effects of the drug Turbezid
During the use of Turbezid, patients may experience some of the following side effects:
Rifampicin: The drug is well tolerated. Undesirable effects of the active substance such as asymptomatic elevation of liver enzymes may occur in the first weeks of treatment and are of no clinical significance. Liver enzyme levels returned to normal when treatment with rifampicin was stopped or when the drug was continued. A possible but rare side effect is hepatitis or jaundice or an influenza-like illness syndrome in people who continue treatment with the drug after a temporary discontinuation of treatment. In this case, the user may experience thrombocytopenia, hemolytic anemia, shock or acute renal failure. Isoniazid: The drug is generally well tolerated. Peripheral nerve degeneration can occur in pregnant women, malnourished women, alcoholics, and people with diabetes. Hepatitis, although uncommon, is a serious adverse reaction that requires immediate discontinuation of treatment. The sudden increase in liver enzyme levels at the beginning of treatment is not clinically significant. Pyrazinamide: The drug is always well tolerated in the body. A possible side effect is a skin rash, which varies from mild to moderate elevations in serum metabolites, especially during early treatment, to severe intoxication. for the liver. Decreased renal excretion of uric acid leads to elevated uric acid levels in the blood, often without any symptoms.
5. Turbezid drug interactions
Rifampicin has an inducer effect, while Isoniazid has an inhibitory effect on some enzymes of the CYP 450 system. Therefore, caution should be taken when taking Turbezide with drugs that are strongly metabolised by CYP 450 enzymes. To ensure therapeutic concentrations, it is necessary to adjust the therapeutic dose with these drugs when used together with Turbezide.
6. Some notes when using the drug Turbezid
6.1. Contraindications of the drug Turbezid People who are sensitive or sensitive to any of the ingredients of the drug. People with impaired liver function due to any cause. Pyrazinamide is contraindicated in people with high blood nitrogen disease or gout. 6.2. Precautions for use The precautions for the use of Turbezide are similar to those for the simultaneous administration of a triple combination containing rifampicin, isoniazid and pyrazinamide alone. All people with TB should have their liver function evaluated before starting treatment. The values of liver enzymes, bilirubin, plasma creatinine, blood count must be within normal range. During treatment with this medicine, you need to have regular check-ups for signs, symptoms and unwanted effects. Because of the high frequency of Isoniazid-induced hepatitis in adults older than 35 years, assessment of liver enzymes should be performed prior to initiation and monthly during treatment. Other factors that can increase the risk of hepatitis include alcohol use, cirrhosis of the liver, intravenous drug use, etc. If you do not have cirrhosis and have normal liver function Usually before treatment, the doctor will order a liver function test when there are signs of fever, vomiting, jaundice or any other unusual symptoms that the patient experiences. People with impaired liver function should use the drug only when necessary and must be closely monitored. These people need to be carefully monitored, especially the GOT, GPT values every 2 to 4 weeks during the course of treatment. If there are signs of hepatocellular damage or clinical symptoms that indicate impaired liver function, Turbezide should be discontinued and other therapeutic modalities should be substituted. After the liver function returns to normal and still requires treatment with Turbezid, the doctor will prescribe periodic monitoring of liver indicators. 6.3. For pregnant and breastfeeding women Pregnant women: Any woman of childbearing age should be asked about her current status or plans to become pregnant before starting antiretroviral therapy. TB. For pregnant women, it is important to get advice on how to get rid of TB with a standard regimen, so that you can complete the delivery. All components of the drug Turbezid can be used in the treatment of tuberculosis in pregnant women. Lactation: Women who are breast-feeding with tuberculosis should receive adequate treatment for TB in each specific stage. Timely treatment and the right regimen is the best way to avoid transmitting TB bacteria to your baby. Mother and child do not need to be isolated and the baby can continue to breastfeed. After the child has been definitively ruled out as having no active TB bacteria, he or she should be on preventive therapy with Isoniazid for a period of 6 months followed by BCG vaccination. Note: When taking Isoniazid, both pregnant and lactating women need to be supplemented with Pyridoxine.
Turbo drugs belong to the group of drugs to treat tuberculosis. Turbezide has three active ingredients: Rifampicin, Isoniazid and Pyrazinamide. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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