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Truvada is a combination of 2 anti-HIV drugs, including Emtriva (Emtricitabine 200mg) and Viread (Tenofovir 300mg). Truvada can be used by people who are at high risk for HIV infection and who are sexually active with people living with HIV.
1. What is Truvada?
Truvada is a combination of two medicines, Tenofovir disoproxil fumarate (sold separately as Viread or generic) and emtricitabine (sold separately as Emtriva). Both drugs belong to a class of HIV medications called nucleoside/nucleotide reverse transcriptase inhibitors.
Truvada is used by adults who have not been infected with HIV to reduce the risk of sexually transmitted HIV. One thing to keep in mind is that Truvada is not a cure-all for sexually transmitted HIV. At the same time, Truvada is still not a superior method to other safe sex methods, so it must still be used in combination with other safe sex methods to achieve maximum effectiveness.
After taking Truvada, the active ingredient Emtricitabine reaches peak plasma concentrations after about 1 to 2 hours, and the active ingredient Tenofovir disoproxil fumarate is about 1 hour. The half-life of Emtricitabine is 10 hours, while Tenofovir disoproxil fumarate is longer, up to 17 hours. After metabolism, the drug is eliminated mainly through the kidneys.
In addition to the indications in the combination regimen with other antiretroviral drugs to treat HIV-1 in adults and children over 12 years of age, Truvada is also used orally in cases of HIV prevention through sexual route. Dosage for adults 1 tablet per day, can be taken with or without meals. Truvada is not indicated for children under 12 years of age, use with caution in people with kidney failure.
2. What disease does Truvada treat?
2.1. Treatment of HIV-1 Infection Truvada is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children weighing at least 17 kg. 2.2. HIV-1 Pre-Exposure Prophylaxis Truvada is indicated for use in at-risk adults and adolescents weighing at least 35 kg for pre-exposure prophylaxis (PrEP) to reduce the risk of transmission. HIV-1 sexually transmitted. Users must have a negative HIV-1 test result immediately before starting treatment with Truvada for HIV-1 PrEP
3. Usage and dosage of Truvada
Dosage of Truvada is to take 1 tablet once a day with or without food. Truvada is not affected by food, so you can use it during or after eating without affecting the treatment effect.
4. Undesirable effects of Truvada
In addition to the therapeutic effects of Truvada, in the course of treatment, users may also experience some unwanted effects.
Common side effects seen in people using Truvada as part of their treatment regimen include diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, and abnormal dreams. and skin rashes. Kidney side effects: Truvada can lead to new or worsening kidney problems, including kidney failure. Bone side effects: Truvada can lead to bone problems, including thinning of the bones, which can lead to fractures. Liver side effects: If you also have hepatitis B virus (HBV) and use Truvada, your hepatitis may get worse if you stop using this medicine. Other potentially serious side effects: new or worsening liver problems and lactic acidosis, a buildup of lactic acid in the blood. The above is not an exhaustive list of all undesirable effects and other possible side effects. You need to pay attention to proactively notify your treating doctor for medical advice about adverse effects when using Truvada.
5. Truvada drug interactions
Truvada drug interactions that can occur during use are as follows:
Truvada can cause kidney toxicity, especially if you also use certain drugs for infections, cancer, thinning bones, organ rejection, bowel disorders, high blood pressure or aches or pains or arthritis (including Advil, Motrin and Aleve). Drugs that may interact with Truvada. Truvada drug interactions may change how it works or increase the effects of unwanted effects. You need to take the initiative in telling your treating doctor or clinical pharmacist what herbal products or health foods, prescription or over-the-counter drugs you are taking. to minimize adverse drug interactions that may cause undesirable effects on the health of users. Interaction of Truvada with food and drink: When using this drug with foods or alcoholic beverages such as wine, beer or tobacco... The cause is in foods, foods Oral administration contains other types of active ingredients, so it can cause antagonism or synergistic effects with the drug. You need to actively read the instructions for using Truvada carefully or consult your treating doctor about how to use Truvada in combination with foods, drinks containing alcohol or using tobacco.
6. Some notes when using Truvada
6.1. Contraindications of Truvada Drugs People with hypersensitivity to the ingredients of Truvada. Someone who has tested positive for HIV-1 or if you do not know your HIV-1 status. If you are HIV-1 positive , you need treatment with medicines other than Truvada to treat HIV-1 . The drug by itself is not a complete treatment for HIV-1. If you are infected with HIV-1 and are on medication only, your condition may become more difficult to treat over time. Truvada's contraindications are absolute contraindications, that is, in any case, these contraindications cannot be flexible in the use of the drug. To ensure the effectiveness of treatment, it is best for patients to strictly follow the doctor's instructions on dosage and use.
6.2. Use of the drug in special populations Truvada use in pregnant women:
Large amounts of data on pregnant women (more than 1,000 pregnancy outcomes) show no malformations or toxicity to with the fetus or neonate related to the active ingredients Emtricitabine and Tenofovir disoproxil. Animal studies with Emtricitabine and Tenofovir disoproxil have not indicated reproductive toxicity. Therefore, the use of Truvada can be considered during pregnancy, if necessary. Use of Truvada in lactation:
Truvada has been shown to be excreted in breast milk. Not enough is known about the effects of Emtricitabine and Tenofovir in neonates. Therefore, Truvada should not be used during breastfeeding. As a general rule, it is recommended that women with HIV should not breast-feed under any circumstances to avoid transmitting HIV to their babies. Fertility:
Currently no human data on the effects of Truvada are available. Animal studies have not shown an adverse effect of Emtricitabine or Tenofovir disoproxil on fertility. Using Truvada with people who are working, driving or operating machines:
Currently, no studies on the ability to drive and use machines have been performed. Individuals should report dizziness during treatment with Truvada. 6.3. Precautions while using Truvada You should not take Truvada if you are allergic to the main active ingredient Emtricitabine or Tenofovir disoproxil fumarate. Do not take Truvada if you also use other medicines that contain Tenofovir, Emtricitabine, Lamivudine, or Adefovir. If you are taking Truvada to reduce your risk of HIV infection: You must test negative for HIV immediately before you start taking Truvada. Do not use Truvada to reduce your risk of infection if you are already infected with HIV, if you have been exposed to HIV on your behalf and have any specific symptoms such as fever, sore throat, night sweats, swollen glands, diarrhea body aches. To make sure Truvada is safe for you, tell your treating doctor if you have ever had:
Liver disease (you may be tested for hepatitis B before you can use this medicine) Osteoporosis with low bone density Have kidney disease. Store Truvada in a dry place, in tightly closed containers, away from moisture and out of direct light. Besides, it is necessary to store Truvada medicine out of the reach of children and family pets. Absolutely do not use Truvada when it has expired, watery, distorted, or shows signs of metamorphosis. Consult environmental protection companies for how to dispose of drugs. Absolutely do not throw or flush the medicine down the toilet or plumbing.
In short, Truvada is a combination of 2 anti-HIV drugs, including Emtriva (Emtricitabine 200mg) and Viread (Tenofovir 300mg). Truvada can be used by people who are at high risk for HIV infection and who are sexually active with people living with HIV. When being prescribed by a doctor to use Truvada, patients should carefully read the instructions for use and consult the treating doctor/clinical pharmacist before using the drug. Absolutely do not arbitrarily buy Truvada to treat the disease at home, because there may be unwanted side effects to health.
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