Uses of Trihexyphenidyl

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1. What is Trihexyphenidyl 2mg?

Trihexyphenidyl is an artificially synthesized tertiary amine with anti-muscarinic properties for the treatment of Parkinson's syndrome. The antimuscarinic effect is exerted through atropine-type peripheral inhibition of the parasympathetic nervous system, including smooth muscle. Trihexyphenidyl is an antispasmodic of smooth muscle, decreased salivation, mild mydriasis, and inhibited the vagus nerve of the heart.
In Parkinson's syndrome, the exact mechanism of trihexyphenidyl is not known specifically, some mechanisms can be accepted such as inhibition of brain motor centers or blockade of centrifugal nerve impulses. At low doses, Trihexyphenidyl inhibits the central nervous system, but at high doses it is stimulant like a sign of atropine toxicity.
Trihexyphenidyl is less effective and more toxic when compared to other Parkinson's drugs such as Levodopa. However, long-term use of trihexyphenidyl has negligible effects on respiration, blood pressure, liver, kidney and bone marrow.

2. Indications and contraindications of Trihexyphenidyl 2mg

2.1.Indications of the drug Trihexyphenidyl 2mg The drug Trihexyphenidyl 2mg is indicated for the treatment of the following cases:
Supportive treatment in patients with Parkinson's syndrome including the following forms of encephalitis, vascular sclerosis or unknown reason. Treatment of extrapyramidal syndrome caused by drugs such as Phenothiazines, Thioxanthene or Butyrophenone. 2.2.Contraindication of Trihexyphenidyl 2mg Drug Trihexyphenidyl 2mg is contraindicated in the following cases:
Tardive dyskinesia Myasthenia gravis Angle closure or narrow angle glaucoma Children are in high temperature environment History allergic to drugs containing the active ingredient Trihexyphenidyl.

3. Dosage and how to use Trihexyphenidyl 2mg

3.1. How to use Trihexyphenidyl 2mg is used orally. Patients should pay attention not to chew the medicine, because it can reduce absorption.
3.2. Parkinson's Syndrome
Dosage Start with 1 mg/day Increase by 2 mg/day over the next 3 - 5 days until 6 - 10 mg/day is reached. Patients with Parkinson's syndrome after encephalitis may increase the dose to 12-15 mg/day or higher if needed. Elderly
Trihexyphenidyl should be combined with Carbidopa to treat Parkinson's in the elderly. Maintenance dose of 2 - 6 mg/day, divided into small doses. Children
From 3 months to 18 years, starting dose 1 - 2 mg/day, divided into doses Then every 3-7 days increase 1 mg depending on the child's response and manifestation of side effects Maximum dose The maximum in children is 2 mg/kg/day. Patients with extrapyramidal disorders due to antipsychotic drugs
Usually a dose of 5-15 mg/day will be effective. Start with a dose of 1 mg, if after a few hours extrapyramidal manifestations are not controlled, the dose should be increased.
It is also possible to reduce the dose of the psychoactive drugs that cause these reactions, and then adjust the dose of both drugs. After these extrapyramidal disorders have been controlled for several days, the dose of Trihexyphenidyl can be discontinued or reduced.

4. Precautions when using Trihexyphenidyl 2mg

4.1.Side effects encountered when using Trihexyphenidyl 2mg

Treatment with Trihexyphenidyl 2mg can cause side effects such as:
Common: Dry mouth, blurred vision. Uncommon: Fatigue, increased heart rate, nausea, vomiting, constipation, confusion, anxiety, hallucinations, dizziness, somnolence, urinary retention, decreased lacrimation, glaucoma, rash. Patients should stop taking the drug as soon as the above symptoms appear during treatment with Trihexyphenidyl 2mg and should promptly notify the treating doctor or go to the nearest medical facility for timely treatment.

4.2. Note the use of Trihexyphenidyl 2mg in subjects

Trihexyphenidyl 2mg should be used with caution in patients with tachycardia, open-angle glaucoma, prostatic hypertrophy or urinary retention. Closely monitor the use of Trihexyphenidyl 2mg in children or elderly patients. Be careful in hot weather or when exercising during treatment with Trihexyphenidyl 2mg. It is necessary to regularly check intraocular pressure and anterior chamber angle when using the drug for a long time. Pregnancy: There are no studies on the safety or efficacy of Trihexyphenidyl 2mg in pregnant women. Therefore, only use the drug when absolutely necessary and strictly follow the instructions of the doctor. Breast-feeding: There is currently no known risk in the infant when the mother uses trihexyphenidyl. However, it is necessary to be very careful and to closely monitor the symptoms of mother and child during treatment. Because Trihexyphenidyl 2mg may cause blurred vision, it will affect the ability to drive or use machines. Therefore, users must exercise extreme caution when performing these tasks.

5. Drug interactions Trihexyphenidyl 2mg

Some drug interactions may occur when taking Trihexyphenidyl 2mg drug concurrently with the following drugs:
Amantadine: increase anticholinergic effect on the central nervous system Digoxin: Trihexyphenidyl reduces the effect of Digoxin when used at the same time. . Phenothiazines: Trihexyphenidyl reduces the effects of this drug.

6. Treatment of missed medication or overdose of Trihexyphenidyl 2mg

When forgetting medicine: It is important to strictly follow the instructions, do not forget more than 2 doses of the medicine. If a dose is missed, the patient should take it as soon as he remembers. However, if it is time for the next dose, then skip the missed dose, take the next dose exactly as directed, the patient does not arbitrarily take a double dose.
Overdose: When taking an overdose of Trihexyphenidyl 2mg, the patient must stop using the drug immediately and go to the nearest medical facility for treatment. Patients need to be induced vomiting, gastric lavage to eliminate the amount of drug just taken, if the time of taking for a long time may have to use Diazepam to reduce symptoms of convulsions or excessive agitation.
The above is all information and notes when using Trihexyphenidyl 2mg, patients should carefully read the instructions for use on the drug packaging, strictly follow the indications, dosage and consult the doctor. treatment for maximum effectiveness and reduced side effects.
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