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Trenstad belongs to the group of antiparasitic, anti-infective, antiviral and antifungal drugs with the main ingredients being Emtricitabine and Tenofovir disoproxil fumarate. The following is information about Trenstad's uses, dosage and precautions when using Trenstad.1. What is the use of Trenstad?
Trenstad drug has the main ingredients Emtricitabin 200mg, Tenofovir disoproxil fumarate 300mg; prepared in the form of film-coated tablets; Packing specification is box of 3 blisters x 10 tablets, box of 1 bottle x 60 tablets.
Trenstad is indicated for use in the following cases:
Use in combination antiretroviral therapy for HIV-1 infected adults in combination with fixed doses of Emtricitabine and Tenofovir disoproxil fumarate; For use in antiretroviral therapy, benefit has been confirmed in combination with emtricitabine and tenofovir disoproxil fumarate. Studies were performed in previously untreated patients.
2. Dosage and how to use Trenstad
2.1. Dosage For adults: The recommended dose is 1 tablet/time/day; For patients with renal impairment, it is necessary to consider adjusting the dose to suit the disease condition. 2.2. Administration In order to optimize the absorption of Trenstad, patients should take the tablets with food. Even a small amount of food increases the absorption of Trenstad.
In case the patient cannot swallow the tablet on its own, the tablet can be dissolved with water or juice in a sufficient amount and taken immediately after dissolution.
2.3. Treatment of overdose In the unlikely event that an overdose occurs, the patient should be monitored by family members for signs of toxicity. If necessary, the patient should be treated with basic supportive measures.
Management can be hemodialysis, which eliminates up to 30% of the emtricitabine dose and about 10% of the tenofovir dose. Whether emtricitabine or tenovovir is eliminated by peritoneal dialysis is currently unknown.
2.4. If a patient forgets to take a dose of Trenstad within 12 hours, it is necessary to eat and drink 1 dose immediately, then continue taking the drug according to the normal regimen. If the missed dose is detected by more than 12 hours and it is almost time for the next dose, skip the missed dose and take the next dose as usual. Patients should not take twice the prescribed dose. If the patient vomits within 1 hour of taking Trenstad, another tablet should be taken. If vomiting occurs 1 hour after taking Trenstad, there is no need to take another dose.
3. Notes when using Trenstad
3.1. Contraindications Do not use Trenstad in patients under 18 years of age; Trenstad is contraindicated in all patients with signs of hypersensitivity to any component of the drug. 3.2. Side effects Side effects when taking Emtricitabine
Very common effects:
Neurological signs: Headache; Gastrointestinal signs: Diarrhea, nausea or vomiting; Musculoskeletal and connective tissue markers: Increased creatine kinase; Common effects:
Signs of blood and lymphatic system: Decrease in neutrophils; Signs on the immune system: Allergic reactions; Metabolic and nutritional signs: Hyperglycemia, hypertriglyceridemia; Psychiatric signs: Insomnia, nightmares; Signs on the nervous system: Dizziness ; Digestive signs: Increased amylase enzymes, pancreatic lipase, vomiting, abdominal pain, indigestion; Liver signs: Increased serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) enzymes, hyperbilirubinemia; Skin and subcutaneous tissue signs: Blisters, pustular rash, maculopapular rash, red, itchy rash, urticaria, melasma; Signs on the whole body: Pain, weakness. Less common effects:
Blood and lymphatic system signs: Anemia; Skin and subcutaneous tissue signs: Angioedema. Side effects occur when taking Tenofovir
Very common effects:
Metabolic and nutritional signs: Hypophosphatemia; Signs on the nervous system: Dizziness; Gastrointestinal signs: Diarrhea, vomiting, nausea or vomiting; Skin and subcutaneous tissue signs: Rash; Body as a whole: Weakness. Common effects:
Nervous system signs: Headache; Digestive signs: Abdominal pain, bloating, flatulence; Signs on the liver: Increased transaminases. Uncommon effects:
Metabolic and nutritional signs: Hypokalemia; Digestive signs: Pancreatitis; Signs of skeletal muscle and connective tissue: Rhabdomyolysis, muscle weakness; Kidney and urinary signs: Increased creatinine, proteinuria. Rare effects:
Metabolic and nutritional signs: Lactic acidosis; Signs of liver: Fatty liver, hepatitis; Signs on skin and subcutaneous tissue: Angioedema; Musculoskeletal and connective tissue signs: Osteoporosis (manifesting as bone pain and sometimes fracture), myalgia; Renal and urinary signs: Renal failure (acute and chronic), acute tubular necrosis, proximal tubules of Fancony's syndrome, nephritis, nephrogenic diabetes insipidus.
4. Precautions when using Trenstad
Use caution when using Trenstad in the following cases:
Patients do not arbitrarily increase the dose of the drug without being prescribed by a doctor; Patients should take the drug with meals to avoid missed doses; Patients should be monitored during drug use; The use of antiretroviral drugs can still infect people close to HIV, so patients should take proactive measures to prevent infection to those around them by: using condoms when in close contact. sex, prevention of blood-borne infections,...; People with liver disease should be monitored when taking Trenstad and their loved ones should have a timely remedy available when the patient has worse signs; Immune activation syndrome can be encountered in HIV-infected people during treatment, so patients should be checked regularly and overcome in time to ensure health; It is not allowed to use Trenstad for breastfeeding women; For women who are pregnant, Trenstad may be considered.
5. Drug interactions
Trenstad may interact with other HIV protease inhibitors causing harmful effects; Caution should be exercised when using Nucleoside reverse transcriptase inhibitors or metabolites, because liver mitochondrial enzymes together with Trenstad; Patients should be monitored when taking drugs that are affected or eliminated by the kidneys. In summary, Trenstad belongs to the group of antiparasitic, anti-infective, antiviral and antifungal drugs with the main ingredients being Emtricitabine and Tenofovir disoproxil fumarate. The drug is indicated for the treatment of HIV. To ensure the effectiveness of use and avoid unwanted side effects, patients need to use the drug exactly as directed by a doctor, professional pharmacist.
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