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Tolepruv is an antibiotic commonly used in the treatment of infections and prophylaxis of post-operative infections. Learning about the effects, dosage and usage of Tolepruv is extremely necessary, helping patients to be able to apply it in each case.
1. What is Tolepruv?
Tolepruv drug is a product of M/s Panacea Biotec Ltd, containing the main ingredient is Ornidazol 500mg and is made in the form of film-coated tablets.
About the use of Tolepruv drug, when taken into the body, the drug will act by transforming into reducing products to create interactions with microbial DNA. From here, it will cause damage to the helix structure of the DNA strand, contributing to preventing protein synthesis and causing cell death of drug-sensitive microorganisms.
2. Indications and contraindications Tolepruv
2.1. Indications Tolepruv is indicated for the treatment of the following infections:
Support treatment of liver amoebiasis, intestinal amoeba, Giardia. Support treatment of urogenital Trichomonas disease. Support the treatment of infections caused by anaerobic bacteria. Used in the prophylaxis of postoperative infections caused by anaerobic bacteria, especially after surgery of the digestive system and gynecology. 2.2. Contraindications Tolepruv drug is contraindicated in patients with hypersensitivity to the drug components or imidazole derivatives.
3. Usage and dosage of Tolepruv
Tolepruv is an oral tablet, used after meals with reference doses as follows:
Amoeba: Adults take a dose of 500mg, use it twice a day and use it for 5-10 days. Children orally at a dose of 25mg/kg, used once a day and used for 5-10 days. Giardiasis : Adults take a dose of 1 or 1.5 g, once a day for 1 or 2 days. Children orally at doses of 30 or 40 mg/kg per day. Trichomoniasis: Adults take a dose of 1.5 g, use a single dose or take a dose of 500mg a day, twice a day for 5 days. Children use at a dose of 25mg/kg, use a single dose. Anaerobic infections: Adults orally at a dose of 500mg every 12 hours or treated by intravenous infusion with a starting dose of 0.5-1g, maintained at a dose of 1g for 5-10 days. Children use at a dose of 10mg/kg every 12 hours for 5-10 days. Treatment of infections caused by anaerobic bacteria after surgery: Adults take Tolepruv at a dose of 1.5g 12 hours before surgery, maintain a dose of 500mg every 12 hours for 3-5 days after surgery. art. Children orally at a dose of 20 - 30mg/kg before 12 hours of surgery and after surgery, continue taking the drug after 12 hours for a period of 3 days.
4. Side effects when taking Tolepruv
When using Tolepruv, some common side effects include:
Drowsiness, headache, digestive disorders leading to nausea and vomiting may occur. Central nervous system disorders with manifestations such as dizziness, tremor, stiffness, convulsions. Patients sometimes experience fatigue and dizziness, temporary loss of consciousness, sensory and peripheral neuropathy. Taste disturbance, liver function impairment, cholestatic hepatitis, increased liver enzyme values, jaundice, pancreatitis.
5. Tolepruv drug interactions
Tolepruv drug has the potential to interact with some other drugs such as:
Concurrent use of Tolepruv and Disulfiram can lead to acute confusion or psychosis. Concomitant use of Tolepruv and coumarin anticoagulants increases the anticoagulant effect. Concomitant use of Tolepruv and Vecuronium bromide prolongs the duration of muscle relaxation. Concomitant use of Tolepruv with alcohol may lead to reactions similar to Disulfiram in some patients. Before taking Tolepruv to treat a disease, patients need to inform their doctor about the drugs they are using to avoid unwanted drug interactions.
6. Notes to remember before taking Tolepruv
Use caution when using the drug in patients with dizziness, mental disorders, liver failure and kidney failure. Pregnant and lactating women absolutely do not use Tolepruv, unless necessary and prescribed by a doctor. Stop treatment with Tolepruv in case of symptoms such as confusion, dizziness, ataxia after taking the drug. The drug can cause confusion, dizziness, so do not use it when you need to drive or operate machinery. Above are the uses, dosage and usage notes when using Tolepruv that readers can refer to. To ensure safety and effectiveness, avoid unwanted side effects, patients should take the medicine exactly as prescribed by the doctor and pharmacist.
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