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Trichopol is an antibiotic whose main ingredient is metronidazole. The drug is administered by parenteral route and administered by medical personnel. This is a prescription medication that belongs to the group of antiparasitic, anti-infective, antiviral, and antifungal drugs. So what disease does Trichopol treat?1. What is Trichopol?
Trichopol 500mg is a drug whose main ingredient is metronidazole. The drug is prepared in the form of a solution for infusion. Trichopol is packaged in a box of 1 FE bag of 100ml. In 1 bag of FE 10ml contains:
Metronidazol 500mg. Excipients are just enough 100ml. Metronidazol is an antibiotic belonging to the nitro-5 imidazole group, effective against intestinal amoeba, gram-negative anaerobes, giardia and trichomonas vaginalis.
Trichopol works by inhibiting protein synthesis of bacteria and protozoa.
Thanks to the above mechanism of action, Trichopol is prescribed by doctors to be used in the following cases:
Diseases caused by amoeba. Treatment of urogenital - genitourinary diseases caused by trichomonas . Nonspecific vaginitis. Disease caused by Giardia intestinalis. The drug is used to treat infections caused by anaerobic bacteria during surgery. Prophylaxis of anaerobic bacterial infections in high-risk surgical cases. The drug is administered continuously with the parenteral route to treat or prevent infections caused by anaerobic bacteria.
2. How to use and dose Trichopol for each case
2.1. How to use Trichopol drug Trichopol drug is prepared in the form of an infusion solution, so patients using the drug by mouth or by infusion should be done under the direction of medical staff.
Dosage of Trichopol 500mg for each case:
In case the drug is used orally: the patient takes about 30 - 50ml of the drug and uses it after meals.
In case of intravenous drug use:
The drug can be infused directly or diluted with 0.9% NaCl solution, 5% glucose solution, 0.9% NaCl glucose and 40 mmol/l KCL solution with appropriate volume. The infusion fluid should be prepared immediately upon administration of Trichopol. Connect the bottle after venting to the dual lume port of the transmitter. Do not use excess solution and do not use medicine if there is any change in drug solution. For patients with hepatic impairment: The drug may be slowly metabolized and may cause accumulation. Therefore, in this case, it is necessary to reduce the dose of the drug by half compared to the usual dose. For patients with renal impairment: Use the same dose as normal patients. For elderly patients: Care and careful monitoring is required when taking the drug. Treatment of anaerobic infections: Intravenous infusion when oral use does not respond.
Treatment for adults and children over 12 years old: 100ml every 8 hours, infusion rate not more than 5ml/min. The maximum dose in adults is 4g, taking the drug for 7 days. For severe cases, the duration of treatment can be extended to 2-3 weeks. Treatment of children under 12 years: infusion rate of 1.5ml/kg body weight every 8 hours. Pre-operative precautions:
The drug should be used 5-10 minutes before surgery. For adults and children over 12 years of age: Trichopol is administered by slow intravenous infusion of 100ml. Repeat the same dose every 8 hours until switching to oral as soon as possible. In case of taking preventive medicine, do not use it more than 12 hours after surgery. For children under 12 years old: Carry out infusion of 1.5ml/kg body weight. Trichopol 500mg drug is used by parenteral route mainly, so missed doses rarely happen. Patients mostly experience cases of drug overdose.
Cases of drug overdose due to patients taking drugs orally. Symptoms of neurotoxicity have been observed very rarely with doses of 6 to 10.4 mg metronidazole for 5 days. Common symptoms of drug overdose include seizures and peripheral neuropathy. When taking a single dose of 15g, it can cause vomiting and nausea, loss of coordination. In case of drug overdose, it is necessary to conduct symptomatic and supportive treatment.
3. Cases where Trichopol should not be used
Patient has a history of allergy to the drug or any of its ingredients. Patients with epilepsy. The patient has a bleeding disorder. Women who are pregnant in the first 3 months and women who are breastfeeding.
4. Unwanted effects that may be encountered when using Trichopol 500mg
During the course of taking the drug, the patient may experience some side effects as follows:
The most common is nausea, vomiting, loose stools, abdominal discomfort, metallic taste, thrush. tongue. The drug can cause blood and lymphatic system disorders: The drug causes leukopenia, thrombocytopenia, and pancytopenia. Drugs acting on nerves: Drugs that cause frostbite, tingling sensations, seizures, dizziness, disorientation and excitability. Drugs that cause eye disorders: Double vision and nearsightedness may occur. Effects on the ear: Causes tinnitus, hearing loss. Drugs causing digestive disorders: Dry mouth, stomatitis, pancreatitis may occur. The symptoms experienced will disappear when the drug is stopped. Skin effects: The drug causes skin damage, skin rashes. Drugs that cause musculoskeletal pain. Effects on the immune system: The drug causes hypersensitivity, urticaria, pruritus, angioedema. When using Trichopol, if the patient experiences the above symptoms or experiences any other unusual symptoms, the patient should notify the doctor for timely treatment.
5. Drug interactions between Trichopol and other drugs
Trichopol when used with anticoagulants, especially warfarin can cause an increased risk of prothrombin. Disulfiram should be stopped 2 weeks before using Trichopol, because disulfiram can increase neurological disorders. Phenobarbital reduces the half-life of the drug, reducing metronidazole plasma concentrations. Trichopol may cause increased kidney damage, increased plasma concentrations and toxicity of lithium. Co-administration with cimetidine increases the half-life of metronidazole. Metronidazole reduces the clearance and increases the serum concentration of phenytoin. Patients should not drink alcohol during treatment and for at least 48 hours after stopping treatment.
6. What should be noted in the process of taking Trichopol?
When taking Trichopol, patients should note the following points:
Trichopol crosses the placental barrier, so it is contraindicated for the early stages of pregnancy, the 2nd and 3rd stages need to be weighed against the benefits. and risk. Metronidazole is excreted in human milk and reaches milk concentrations close to serum concentrations. Therefore, Trichopol should not be used by women who are breast-feeding or if it is necessary to stop breastfeeding. Caution should be exercised when administering the drug to patients with existing manic CNS disease, severe hepatic impairment, and hepatic encephalopathy. During treatment, patients need to be monitored blood cell counts, especially those who are on drug therapy for more than 10 days. Trichopol is a highly effective drug for infections caused by anaerobic bacteria. The drug is prepared in the form of an infusion administered by a medical professional, so overdose is very rare. However, Trichopol can interact with many drugs, so it is necessary to consult a doctor to ensure safety and effective treatment.
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