Uses of Tinidamed

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1. What is Tinidamed?

Tinidamed medicine has the main ingredient is Tinidazol 500mg, is made in the form of film-coated tablets and packed in the form of a box of 1 blister x 4 tablets, a box of 5 blisters x 4 tablets.
Tinidamed is indicated for use in the following cases:
Prevention of postoperative infections caused by anaerobic bacteria, especially infections related to colon, gastric and gynecological surgery. Specifically, the drug is indicated for the treatment of the following diseases:
Infections caused by anaerobic bacteria such as: Intra-abdominal infections such as peritonitis, abscesses. Gynecological infections such as endometritis, endometritis, and ovarian cysts. Sepsis . Postoperative wound infection. Skin and soft tissue infections. Upper and lower respiratory tract infections such as pneumonia, purulent pleurisy, lung abscess; Nonspecific vaginitis; Acute ulcerative gingivitis; Genitourinary Trichomonas infections in both men and women; Giardia infection; Intestinal amoebiasis; Amoeba resides in the liver.

2. Dosage and how to use Tinidamed

2.1. Dosage In prevention: Prevention of infection after surgery: Adults take a single dose of 2g, 12 hours before surgery.
Treatment:
Anaerobic infections: Adults, take 2g on the first day, then take lg, once daily or 500mg, 2 times/day. Usually 5-6 days of treatment is sufficient, but the duration of treatment depends on the clinical outcome. In particular, when the complete treatment of infections in some sites can be difficult, if necessary, prolong the treatment for more than 7 days. Nonspecific vaginitis: Adults, a single dose of 2g for 2 days; Acute gingivitis: Adults, a single dose of 2g. Genitourinary Trichomoniasis
Adults: 2g single dose. Simultaneously, the same treatment should be given to the sexual partner; Children: A single dose of 50-70mg/kg body weight. A repeat dose may be used if needed. Giardia Infection
Adults: Single dose of 2g; Children: A single dose of 50-75 mg/kg, orally once, with a repeat dose, if necessary. Intestinal amoebiasis
Adults: Single dose of 2g, for 2-3 days; Children: Use a single dose of 50-60 mg/kg body weight per day for 3 consecutive days. Liver amoeba
Adults: The total dose varies from 4.5 to 12g, depending on the virulence of Entamoeba histolytica. With hepatic amoeba, it may be necessary to combine drainage with treatment with tinidazole. Initially give 1.5-2g, 1 time per day, for 3 days. If the 3-day course of treatment is not effective, it should be continued for up to 6 days; Children: 50-60mg/kg, orally once, for 5 consecutive days; Elderly: There are no special dose recommendations. 2.2. How to take Tinidazole is usually taken orally in a single dose during or after a meal.
2.3. Treatment of Overdose Symptoms: There have been no reports of overdosage of tinidazole in humans; Treatment: There is currently no specific antidote for tinidazole overdose. Treatment is mainly symptomatic and supportive, can gastric lavage, tinidazole easily by dialysis.

3. Notes when using Tinidazol

3.1. Contraindications Contraindicated to use Tinidamed in the following cases:
Patients with hypersensitivity to tinidazole or to imidazol nitro derivatives; Hematopoietic disorders or a history of acute porphyria; Contraindicated in the first trimester of pregnancy and nursing mothers; Patients with physical neurological disorders. 3.2.Side effects During the use of Tinidazol, patients may experience some of the following side effects:
Common: Nausea, loss of appetite, abdominal pain; Uncommon: Dizziness, headache, vomiting, diarrhea; Rare: Allergies, fever, reversible leukopenia, stomatitis, pruritus, skin rash, arthralgia, peripheral neuropathy, dark urine. Discontinue use and consult a doctor if: Occurrence of abnormal neurological symptoms such as dizziness, lightheadedness, ataxia, peripheral neuropathy (abnormal sensations, sensory disturbances, decreased sense).
3.3. Precautions During treatment with tinidazole, alcohol-containing preparations should not be used, as disulfiram-like reactions (flushing, abdominal cramps, vomiting, tachycardia) are possible. For pregnant women: Tinidazole crosses the placental barrier. This drug is contraindicated in pregnant women during the first 3 months of pregnancy, because the effect of the drug on the fetus is unknown. There is no evidence that tinidazole causes harmful effects in later stages of pregnancy, but the benefits of dosing should be weighed against the potential harm to the fetus and mother in the second trimester. and the third of pregnancy. Lactation: Tinidazole is excreted in breast milk. After taking the drug for 72 hours, tinidazole can still be found in milk. Should not be used for women who are breastfeeding, or only breast-feeding for at least 3 days after stopping the drug. Ability to drive and use machines: No special caution is required. However, drugs with similar chemical structure, including tinidazole, have been associated with various neurological disorders such as vertigo, vertigo, ataxia, peripheral neuropathy (sensory abnormalities, confusion). dysesthesia, decreased tactile sensation) and rarely convulsions. If there are any neurological abnormalities during treatment with tinidazole, the patient should immediately discontinue the drug. 3.4.Drug interactions With alcohol: Concomitant use of tinidazole and alcohol can cause disulfiram-like reactions, this combination should be avoided; With Cimetidine: Cimetidine may decrease the elimination and increase the serum concentration of tinidazole; With Rifampicin: Rifampicin may increase elimination and reduce the therapeutic effect of tinidazole; With anticoagulants: Tinidazole may increase prothrombin time (PT) and enhance the effect of anticoagulants. Tinidamed has the main ingredient is Tinidazol 500mg. The drug is indicated for the treatment of certain infectious and bacterial diseases. Patients should read the instructions carefully when using the drug, and consult with the doctor and pharmacist before using it to increase the effectiveness of treatment and avoid unwanted side effects.
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