Uses of the drug Turbe

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1. What is the drug Turbe?

What is the drug Turbe? Turbe medicine contains 2 main ingredients: Rifampicin 150mg and Isoniazid 100mg. In addition to the main ingredients, the drug also contains excipients just enough for 1 tablet.
Active ingredient Rifampicin is an antibiotic with high activity against Mycobacterium strains, especially tuberculosis and leprosy. This antibiotic strongly inhibits bacterial RNA synthesis, because it strongly inhibits synthesizing enzymes. Isoniazid active ingredient has a good bactericidal effect, especially limiting the multiplication of many types of bacteria. Accordingly, when there is a strong enough drug concentration, a large number of bacteria are destroyed, while minimizing the massive invasion in the body. Turbe is made in the form of film-coated tablets, so it is taken orally.

2. Indications and contraindications of the drug Turbe

Indications and contraindications of the drug Turbe are as follows:
2.1. What are the uses of Turbe? Turbe is indicated for the treatment of pulmonary tuberculosis and patients with extrapulmonary tuberculosis.
2.2. Contraindications Contraindicated to use Turbe drug in the following cases:
The patient is sensitive to 1 or the ingredients contained in the drug Turbe. Patients with impaired liver function Patients with polyneuritis Patients with epilepsy. Porphyrin metabolism disorders in patients who are sensitive to the riphampicin component contained in the drug, because it is related to the ability to induce cytochrome P450 enzymes in the liver. Contraindications here are absolute contraindications, that is, patients who are not for any other reason but who are contraindicated can be flexible in using the drug.

3. Dosage and how to use Turbe

3.1. How to use Turbe drug Turbe drug is made in the form of film-coated tablets, so the drug is used orally. Patients should take Turbe in the morning on an empty stomach. Care should be taken not to divide the dose of the drug into smaller doses for use.
3.2. Dosage of Turbe drug Based on the weight of each patient, the doctor has specified a specific dose:
Patients weighing over 50 kg: The dosage is 4 tablets per day. People weighing less than 50 kg: The dosage is 3 tablets per day. It should be noted: The above drug dosage is for reference only, patients need to take the drug exactly as prescribed by the doctor or pharmacist. Absolutely do not use more drugs than prescribed with the desire to speed up the treatment process.

4. Undesirable side effects of the drug Turbe

Because the drug Turbe has two main ingredients, the unwanted side effects may come from these 2 ingredients:
Rifampicin: This active ingredient can increase liver enzymes from the time the patient starts using the drug. , although the patient has no obvious clinical manifestations. In most cases, liver enzymes return to normal when the patient stops taking the drug. However, some patients develop hepatitis as a side effect of rifampicin and develop jaundice, impaired liver function, thrombocytopenia, and anemia. Isoniazid: This active ingredient reduces the ability of peripheral nerve conduction in pregnant patients, diabetics, and alcoholics. In addition to the side effects mentioned above, if during the use of the drug, the patient experiences any side effects, it is necessary to stop using the drug and notify the doctor. In severe cases, the patient should immediately go to the nearest medical center for examination and treatment.

5. Drug interactions

Rifampicin increases the induction of cytochrome P450, thereby increasing metabolism, excretion, and at the same time reduces the activity of some drugs such as nifedipine, isradipine nimodipine. Therefore, it is necessary to limit the use of the combination of Turbe drugs with the above drugs. If it is necessary to use the combination, the patient should take 6-8 hours apart. Concomitant use of Isoniazid with antiepileptic drugs may increase the toxicity of the drug in the serum. Therefore, it is necessary to adjust the drug dosage when combined with drugs such as: Alfentanil, anticoagulants (indadion derivatives), coumarin, Phenytoin, benzodiazepines and enflurans,... niridazole and isoniazid further increase the toxicity to the nervous system. From there, it easily leads to symptoms of convulsions, disturbances of consciousness, mental disorders. Medicines containing aluminum salts, patients should take about 1 hour from the active ingredient Isoniazid, thus increasing the absorption of Isorapid active ingredients. In addition, when used together with stimulants, such as: alcohol, beer, tobacco... will increase the risk of causing liver damage to patients.
Therefore, to avoid drug interactions, patients need to inform their doctors about the drugs, herbs, and supplements they are using. From there, doctors consider and consider advice to adjust the appropriate dose and time of use.

6. Notes when using the drug Turbe

In the process of using Turbe, patients need to pay attention to the following issues:
If using Turbe for patients with alcoholism, it is necessary to evaluate liver function indicators. Besides, during use should also monitor, test liver enzymes regularly to assess the ability to metabolize drugs in the liver. Patients need to pay attention to the symptoms of thrombocytopenia, anemia, impaired kidney function during the course of taking Turbe. Patients with polyneuritis, diabetes, or reduced conduction capacity. Peripheral nerves should use about 10mg of Vitamin B6 while using Turbe. During the use of Turbe, the patient should not use stimulants such as alcohol, tobacco, beer. Pregnant women: The use of any antibiotic during pregnancy can affect the fetus. Accordingly, if pregnant, pregnant women use Turbe drug can increase the possibility of bleeding, placental abruption. Therefore, mothers need to supplement with Vitamin K for prevention and only use Turbe when consulted and prescribed by a doctor. Breast-feeding women: To ensure safety, nursing mothers need to consult a doctor before use, to avoid effects on the nursing infant. Turbe should be stored in a cool, dry place. You should avoid exposing the medicine to excessive humidity, or places with direct sunlight. If the drug is not well preserved, the concentration of substances will be changed, and the activity will be reduced. Before using the drug, the patient should carefully consider the expiry date, if the drug is discolored, watery, do not use it anymore. Consult the environmental company for the breakdown of the drug. Never flush the medicine down the toilet or down the drain.
In summary, Turbe drug contains 2 main ingredients, Rifampicin and Isoniazid. The drug is indicated for the treatment of people with pulmonary and extrapulmonary tuberculosis. To ensure effective use and avoid unwanted side effects and interactions, patients need to take the drug exactly as directed by the doctor or pharmacist. Absolutely do not arbitrarily buy Turbe medicine to self-treat to avoid unwanted effects on health.
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