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Tirokoon tab 100mg contains the active ingredient Tiropramide, indicated in the treatment of irritable bowel syndrome, gastrointestinal spasms, biliary colic and biliary spasm. Let's learn about the notes when using the drug Tirokoon through the article below.1. Uses of the drug Tirokoon tab
1.1. Indications for use of the drug Tirokoon tab
Tirokoon tab 100mg contains the active ingredient Tiropramide - belongs to the group of antispasmodic gastrointestinal smooth muscle. Tirokoon is indicated in the following cases:
Gastrointestinal cramps, irritable bowel syndrome; Biliary colic and biliary spasms such as cholecystitis, cholelithiasis, cholangitis; Treatment of renal colic and urogenital spasms such as ureteral stones, kidney stones, cystitis, pyelonephritis; Treatment of uterine contractions such as threatened miscarriage, dysmenorrhea, uterine contractions. 1.2. Pharmacodynamics Active ingredient Tiropramide has antispasmodic effects on gastrointestinal smooth muscle, genitourinary tract and urinary tract, but has little effect on vascular smooth muscle. Tiropramide is an antispasmodic by a mechanism that increases intracellular cAMP levels, by activating cAMP synthesis. Increased cAMP levels relax smooth muscle and block calcium flux across the membrane. Tiropramide sequesteres calcium in the sinuses of intracellular organelles by stimulating the binding of calcium ions to the smooth muscle reticulum. Tiropramide also inhibits the absorption and release of calcium ions.
1.3. Pharmacokinetics
Tiropramide plasma concentrations are detected after 18-27 minutes of a single dose, peak plasma concentrations are reached after 1-1.7 hours. The half-life of tiropramide is about 2.34 to 2.61 hours. Tiropramide and its metabolites were recovered in urine via liquid chromatography within 24 hours of oral administration.
2. Dosage of Tirokoon tablet
Tirokoon tablets are to be taken orally with or without food. The recommended dose is as follows:
Adults and children from 12 years old: Take 1 tablet/time x 2-3 times/day; Children under 12 years of age: Safety and effectiveness have not been established in children under 12 years of age. 3. Side effects when using Tirokoon tablets Tirokoon drugs are well tolerated and rarely cause side effects, some rare side effects such as vomiting, nausea, constipation, itching, erythema, thirst and dryness mouth.
In case of experiencing unwanted effects, the patient should stop using the drug and notify the treating doctor for timely treatment.
4. Note when using Tirokoon tablet 4.1. Contraindications Contraindicated to use Tirokoon drug in the following cases:
Patients with hypersensitivity to Tiropramide or to any component of the drug Tirokoon; Patients with mechanical narrowing of the gastrointestinal tract; People with colonic hypertrophy; People with severe liver failure; Children under 12 years old; Women are breastfeeding. 4.2. Use caution when using Tirokoon 100mg in the following cases:
Pregnant women, only use the drug when absolutely necessary and must be prescribed by a doctor; Patients with prostate enlargement , glaucoma ; In case the patient detects an allergic reaction (itching, erythema) must stop using the drug immediately. Tirokoon may interact with antihypertensive drugs, leading to an increase in the antihypertensive effect of antihypertensive agents. Therefore, the patient should take the drug exactly as prescribed by the doctor.
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