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Ticodex is an eye drop used to treat problems with conjunctivitis, keratitis. So, what is ticoldex drug, contraindicated in what diseases? Let's find out through the article below.
1. What is Ticoldex?
Ticoldex is manufactured at Danapha Pharmaceutical Joint Stock Company with the main ingredients being Dexamethasone Sodium Phosphate and Chloramfenicol.
Pharmacodynamics
Dexamethasone in the drug works by binding to cell receptors. As a result, some genes are changed during translation, so they have anti-inflammatory, anti-allergic and immunosuppressive effects. The ingredient Chloramphenicol in the drug has the ability to inhibit the process of arranging amino acids to synthesize bacterial proteins by binding to the 50S subunit of the ribosome, helping to bacteriostatic. Moreover, at high concentrations, it has a bactericidal effect or with susceptible strains of bacteria.
Pharmacokinetics
Dexamethasone : After eye drops, the drug is absorbed into the aqueous humor of the cornea, iris, choroid, and retina. Systemic absorption is possible but when the drug is administered. The drug is distributed mainly in the liver and kidneys. Dexamethasone sodium phosphate is rapidly converted to circulating dexamethasone. Up to 77% of dexamethasone is bound to albumin. The mean half-life was 3.6+/- 0.9 hours. The drug is eliminated by the kidneys.
Chloramphenicol: The drug is absorbed into the aqueous humor and then to the circulatory system. Chloramphenicol is found in cerebrospinal fluid, saliva, and highest concentrations in the liver and kidneys. Chloramphenicol also crosses the placental barrier and breast milk. Excreted mainly in the urine as glucuronic conjugates and to a small extent in bile and feces. The half-life is 1.5-5 hours, increased in patients with hepatic impairment and in neonates 24-48 hours.
Ticodex is a clear, colorless or slightly yellowish liquid eye drop, with no odor or bitter taste. The drug is packaged in a plastic vial with a volume of 5ml.
2. What are the effects of Ticoldex?
The drug Ticoldex has the effect of preventing bacterial infections and treating lesions in the eyes, prescribed by doctors to treat the following cases:
Conjunctivitis caused by bacteria. Non-traumatic conjunctivitis. Keratitis . Tear gland infection. Eyelid inflammation. Helps decontaminate eyes before and after surgery
3. Dosage and usage
Dosage
Usual dose: 1-2 drops/day, use several times/day. The duration of each course of ticoldex treatment is about 10 days. The doctor will monitor the condition to give appropriate indications. How to use
Use your hands to open the lid of the vial of ticoldex and put it in your eyes. Do not let the tip of the vial touch your eyes and eyelids. After instillation, close your eyes and wipe off excess with a clean cloth. Before and after instillation, hands must be clean. After instillation, close the vial tightly after use.
4. How to handle missed dose, overdose
Missed dose : Minimize forgetting to use ticoldex as directed by your doctor to achieve the desired effect. However, if you forget to take a dose, take the missed dose as soon as possible. If it is almost time for you to take your next dose, skip the missed dose and take the next dose as directed by your doctor. Do not arbitrarily double the dose as directed.
Overdosage : There have been no reports of overdose with ticoldex, because the content of the active ingredient in the eye drops is small. However, only take the medicine according to the dose and time prescribed by the doctor. In the process of taking Ticoldex, if there are any unusual signs, you should immediately contact the doctor who prescribed it or go to the nearest medical facility for timely intervention to avoid leaving significant consequences. regret.
5. Contraindications
Absolutely do not use the drug for the following cases:
Allergy to the ingredients of the drug Ticodex. People with myelosuppression, infants, viral and fungal infections of the eye, glaucoma.
6. Side effects
During the use of the drug Ticoldex may cause some of the following side effects:
Congestion. Itchy eyes. Allergic reaction. If the patient has any suspicious signs related to the use of Ticordex, call the doctor who prescribed it immediately for advice and timely intervention.
7. Drug interactions
Avoid taking Ticordex with other antibiotic-containing eye drops or sulphonamides.
Please list the drugs you are using or plan to use while taking Ticodex and inform your doctor for advice on how to use it most effectively to limit other possible harmful effects. happen.
8. Some notes when using Ticodex
Pregnant and lactating women: Currently, there are no adequate studies on the safety of the drug when used for these subjects. It is necessary to carefully consider the benefits and harms of the drug to make the right decision to use the drug in case it is necessary to use the drug. Ticoldex can be breast milk, so if you must use it, you should stop breastfeeding.
People who drive and operate machinery: Due to some common side effects for people using ticoldex, it is itchy eyes, light burning sensation in the eyes, blurred vision causing visual disturbances right after eye drops do. affect the work for these objects. After childhood, life takes about a few minutes until vision is clear before driving and operating machinery. In case the patient is prescribed by the doctor to only use more than one type of eye drops in the same course of treatment, the two drugs should be used at least 5 minutes apart to help the drugs work best.
Depending on the patient's condition, the doctor will appoint an appropriate time to take the drug, because ticoldex can cause a fungal infection in the eye, so it can't be used for a long time. In cases where it is necessary to use Ticodex for a long time, monitor intraocular pressure and vitreous clarity.
9. Preservation of drugs
Store the medicine in a place away from moisture and sunlight, the temperature should be below 30 degrees Celsius. Before taking out to use, carefully check the expiry date of the medicine on the outside of the package. Check the quality of the medicine if there are signs of damage, mold, or discoloration. Should not be left where children can reach.
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