This is an automatically translated article.
Metazydyna drug belongs to the group of cardiovascular drugs, containing Trimetazidine hydrochloride, which is effective in the prevention and treatment of angina pectoris. For more detailed information about this drug, please read the article below.
1. What is Metazydyna?
Before learning about the uses of Metazydyna 20mg, let's find the answer to the question: "What is Metazydyna drug?".
Metazydyna is a product of Pharmaceutical Works Polfa in Pabianice Joint - Stock Co, Poland. Each Metazydyna 20mg tablet has the main ingredient Trimetazidine hydrochloride and other excipients such as: Microcrystalline cellulose, Croscarmellose sodium, Povidone, Magnesium stearate, Hypromellose E5, Hydroxypropyl cellulose, Macrogol 4000, Cochineal red dye (E124), Cochineal red (E124) just enough 1 tablet.
Metazydyna is packaged in a box of 3 blisters × 10 tablets, the dosage form is film-coated tablets.
Pharmacodynamics
Trimetazidine is the only antianginal and anti-ischemic agent in the new class of compounds with anti-ischemic effects without causing any hemodynamic changes, and improving the patient's condition. myocardial ischemia.
Pharmacokinetics
Metazydyna is rapidly absorbed with a peak in plasma about 2 hours after dosing. Absolute bioavailability is more than 85%. The maximum plasma concentration is about 85 ng/ml following a single dose of 40 mg trimetazidine. The apparent volume of distribution is 4.8 l/kg ; plasma protein binding is low, about 21%.
2. What are the effects of Metazydyna?
So what does Metazydyna do? According to experts, Metazydyna has the following uses:
Metazydyna 20mg has a protective effect on heart muscle cells and liver. Prevent metabolic acidosis and overactivity of the sodium - hydrogen pump, reduce the phenomenon of cytotoxicity. Increases the concentration of energy-rich substances in the cell, helping to protect the mitochondria. Fight free radicals and lipid oxidation, reduce arteriosclerosis and stabilize cell membranes. Supply energy to cells, prevent ischemia. In addition, it also has the effect of shortening the time to occur the most fibrillation. Based on the above effects, the drug is applied to treat the following diseases:
Prevention and treatment of angina. Damage to blood vessels in the retina. Vasomotor vertigo, Ménière's syndrome, tinnitus. On the other hand, in the following cases, the drug Metazydyna is not allowed to be prescribed:
Patients with hypersensitivity to Trimetazidine hydrochloride or any of its ingredients. Patients with heart failure, cardiovascular collapse. Movement disorders, tremor, Parkinson's disease. Severe kidney failure.
3. Dosage and usage
3.1. How to take Metazydyna is taken orally. Take the whole tablet without breaking or crushing the tablet because it affects the bioavailability of the drug. Patients should take the drug with meals.
3.2. Dosage According to experts, the usual dose is 1 tablet of 20 mg x 3 times/day. However, for some special subjects, the dose will be changed, specifically:
Patients with moderate renal impairment (creatinine clearance 30 - 60 ml/min): The recommended dose is 1 20 mg tablets twice a day, with breakfast and dinner. Elderly patients may have a higher than normal level of trimetazidine sensitivity due to age-related decline in renal function. Care should be taken when calculating the dose for elderly patients. Children under 18 years of age should consult a doctor before use in case of overdose. The above dosage is for reference only, patients should consult a doctor to get the right dose. If you miss a dose, take it again as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not take a double dose to make up for a missed dose as this may lead to an overdose. If you accidentally overdose and there are abnormalities, you should immediately notify the treating doctor for timely solutions.
4. Side effects of the drug Metazydyna
During the use of the drug, patients may experience some side effects such as:
Nausea, loss of appetite, discomfort in the epigastric region, stomach. Increase liver enzymes. Headache. The above are not all the side effects of Metazydyna 20mg. If you experience any unusual symptoms that are suspected to be caused by the drug, the patient should immediately notify the doctor to receive timely advice and treatment.
5. Notes when using the drug Metazydyna
Patients who show symptoms of dizziness, tinnitus, ... are not allowed to prescribe drugs. In case the patient is taking trimetazidine to treat these symptoms, it is necessary to discuss with the doctor to choose an alternative medicine. Patients with Parkinson's disease or with symptoms similar to Parkinson's, hand tremors, restless legs syndrome are contraindicated with Metazydyna. Trimetazidine should be discontinued altogether in patients with progressive movement disorders such as Parkinson's syndrome. If Parkinson's syndrome persists for more than four months after stopping the drug, a neurologist should be consulted. Trimetazidine is not suitable for the treatment of acute attacks of angina or for the initial treatment of patients with unstable angina or myocardial infarction. Trimetazidine should not be used before admission and during the first days of hospital stay. During an acute angina attack, coronary artery bypass grafting and a change of therapy (treatment with revascularization drugs) should be considered. A fall, unsteadiness, or drop in blood pressure may occur, especially in patients taking antihypertensive drugs. The drug contains red cochineal, which can cause allergic reactions. There are no adequate reports on the harmful effects of the drug on pregnant women. However, pregnant women need to be very careful when using the drug, especially pregnant women in the first 3 months of pregnancy. Women who are breastfeeding should not use this medicine to avoid affecting milk sugar and harming the infant. For patients who frequently drive and operate machinery, the use of medication may need to be considered. Because some side effects of Metazydyna such as dizziness can reduce the ability to concentrate and stay alert when driving or operating machinery. To use the drug properly and effectively, patients need to read the instructions for use carefully before using. Elderly people and patients with kidney failure need to consult a doctor before intending to use the drug. This drug should not be used by patients under 18 years of age to ensure the safety and effectiveness of Metazydyna 20mg, which has been proven effective in the treatment of many medical conditions. However, the dose and manner of administration determine the safety of the drug. Therefore, to avoid side effects of the drug Metazydyna 20mg, patients should follow the instructions of the doctor.
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