Uses of the drug Combigan 5ml

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1. Uses of Combigan

The effect of Combigan 5ml is to reduce intraocular pressure (IOP) in patients with chronic open-angle glaucoma or glaucoma who have responded inadequately to topical beta-blockers. Combigan bottle 5ml relieves discomfort, burning, irritation caused by dry eyes, main active ingredients include Brimonidine tartrate and timolol maleate.
Combigan consists of 2 main active ingredients: Brimonidine tartrate, Timolol maleate and combined with a sufficient number of excipients. These two ingredients are used to reduce the increase in intraocular pressure (IOP) by complementary mechanisms and the combined effect leads to a decrease in intraocular pressure, the effect will be higher than when either alone is used. this component.
Combogan has a quick effect after use. Brimonidine tartrate is an alpha-2 adrenergic receptor agonist that is 1000 times more selective than the alpha-1 adrenalin receptor. This selectivity renders the drug effective only in lowering intraocular pressure without dilating the pupil. and did not induce vasoconstriction in the microvasculature associated with human retinal transplantation. Brimonidine tartrate is thought to reduce intraocular pressure (IOP) by blocking aqueous inflow and increasing epidural outflow.
Timolol is a non-selective beta-adrenergic and beta-adrenergic receptor blocker with no intrinsic sympathomimetic, direct myocardial depression, or local anesthetic effects. Timolol lowers intraocular pressure by reducing the production of aqueous humor. The exact mechanism of this effect is unknown but may be due to inhibition of cyclic AMP synthesis by endogenous beta-adrenergic stimulation.

2. How to use Combigan 5ml effectively

First make your hands clean by washing them properly with soap, then apply eye drops. Do not touch the dropper tip or let it touch your eyes or any other surface to avoid contaminating the device. Contact lenses may absorb the preservative in this medication, so if you are wearing contact lenses remove them before instilling the drops in your eyes. After 15 minutes of instillation, put your contact lenses back on.
Proceed to tilt your head back, lift your eyes up and pull your lower eyelid down to form an eye drop position. Hold the dropper directly over the eye and place 1 drop in the pouch, usually 2 times daily (12 hours apart) or as directed by your doctor. After instilling the drops, bring your eyes down gently and close them for 1 to 2 minutes. To prevent medication from coming out of your eyes, place a finger in the corner of your eye (near the nose) and press gently. Do not blink and do not rub your eyes after applying the drops, although you may feel some discomfort or itching. Apply evenly to both eyes with the amount of medication as directed.
If you are using another eye medication (such as drops or ointment), wait at least 10 minutes before applying with other medications. Note the use of ointment after using Combigan eye drops.
You can use this medicine regularly for maximum effect. Besides, use it at the same time every day to make it easier to remember. Even if you are feeling better or have stabilized keep taking the medicine. Because most people with glaucoma or high eye pressure don't feel sick.

3. Possible side effects when using Combigan

While using Combigan, you may experience some of the following side effects:
Temporary blurred vision, temporary burning/stinging/itching/redness, Watery eyes Dry eyes, Dry mouth, Colds Feeling like something is in the eye, Headache, dizziness Drowsiness. If any of these effects persist or get worse, tell your nearest doctor or pharmacist right away.
If serious side effects occur, notify your treating doctor or prescriber immediately, including:
Change in vision, Eye sensitivity to light, eye pain/swelling/draining fluid, Slow/irregular heartbeat, Muscle weakness, Unusual fatigue, Mental/mood changes, cold/numbness/pain in hands or feet, Swelling of ankles/feet, Unknown sudden weight gain cause, shortness of breath. Get medical help right away if you have any very serious side effects, including: difficulty breathing, chest pain, weakness on one side of the body, trouble speaking, confusion, persistent dizziness, fainting faint.
It is very rare to have serious side effects with this medicine. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat) ), severe dizziness or trouble breathing.

4. Prevention of unwanted effects?

Before using this product, tell your doctor or pharmacist if you are allergic to brimonidine, timolol, apraclonidine, or if you have any other allergies. You need to provide detailed information to get the most appropriate advice.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Lung disease (such as current or past asthma, severe chronic obstructive pulmonary disease) - COPD), Irregular heartbeat (sinus bradycardia), heart disease (severe heart failure, cardiogenic shock), Kidney disease, Liver disease, Vascular disease (such as thromboembolic disease, Raynaud's phenomenon) ), Blood circulation disorder (coronary/cerebral insufficiency), Dizziness after standing (orthostatic hypotension), Diabetes, depression, overactive thyroid (hyperthyroidism), Muscle weakness disorder (such as myasthenia gravis), Severe allergies. If you have an infection, eye injury, or eye surgery, ask your doctor whether you should continue using this current vial.
If you have diabetes, this product may stop the fast/pounding heart rate you normally feel when your blood sugar gets too low (hypoglycemia). Other symptoms of hypoglycemia, such as dizziness and sweating, are not affected by this medicine.
Combigan may make you dizzy or drowsy or temporarily blur your vision. If you continue to use alcohol or marijuana, it can make the symptoms of dizziness and drowsiness stronger. Activities that require alertness or clear vision, such as driving or operating machinery, should be halted until these symptoms are gone. Limit alcoholic beverages. The patient needs to be honest with the doctor if you are using marijuana.
During pregnancy, use only when prescribed by a doctor. The benefits of taking this drug during pregnancy must outweigh the risks of its use.
This Combogan may pass into breast milk, but is unlikely to harm a nursing infant. Consult a specialist if you are breast-feeding.

5.Combigan drug interactions

Some products that may interact with this drug include: beta blockers taken by mouth (such as propranolol), certain antidepressants (SSRIs such as fluoxetine, tricyclics such as amitriptyline), digoxin, epinephrine, fingolimod, high blood pressure medicine (such as clonidine, methyldopa), quinidine.
You need to tell your pharmacist or doctor if you are taking one of the other medicines that cause drowsiness such as opioid pain relievers or cough suppressants (such as codeine, hydrocodone), alcohol, marijuana, sleeping pills or antidepressants, muscle relaxants, or antihistamines (such as cetirizine, diphenhydramine).
If you are taking more than one medicine at the same time be sure to check the labels on all your medicines (such as allergy or cough and cold products), as they may contain ingredients that can cause problems. sleepy. In addition, you should also consult with your doctor and pharmacist about the safety of other drugs and the use of Combigan.
If you miss a dose, take it again as soon as you remember, if it is almost time for the next dose, skip the previous dose. Never use a double dose the next time you miss a dose.
Combigan may be harmful if swallowed. If someone has overdosed and has serious symptoms such as fainting or shortness of breath, slow heart beat, immediately go to the nearest medical facility for advice and diagnosis.
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