This is an automatically translated article.
Tenfovix drug is made in the form of film-coated tablets, with the main ingredient being Tenofovir disoproxil fumarate. The drug is used in combination with other antiretroviral drugs to treat HIV infection, chronic hepatitis B virus.
1. Uses of Tenfovix 300mg
Tenfovix 300mg medicine contains the main chemical is 300mg Tenofovir disoproxil. Tenofovir disoproxiI fumarate is able to inhibit HIV-1 activity by competitively binding directly to the natural substrate deoxyadenosine 5 -triphosphate. It then merges into the viral DNA, causing the end of the DNA chain. Tenofovir diphosphate can inhibit DNA polymerase α, β and mitochondrial DNA polymerase. Tenfovix is indicated for use in:
Combination with other antiretroviral drugs in the treatment of HIV infection; Treatment of chronic hepatitis B virus infection in adults. According to experts, Tenfovix is not indicated for use in the following cases:
People who are sensitive to the ingredients and excipients of the drug; Women are breastfeeding.
2. How to take and dose of Tenfovix
Tenfovix is used orally. Dosage of this drug is recommended as follows:
Usual dose: 1 tablet (300mg)/time/day; Dosage for patients with renal failure : Creatinine clearance ≥ 50ml/min: 1 tablet (300mg) every 24 hours; Creatinine clearance 30 - 49ml/min: 1 tablet (300mg) every 48 hours; Creatinine clearance 10 - 29ml/min: 1 tablet (300mg) twice a week; Hemodialysis patients: 1 tablet (300mg) every 7 days or after a 12-hour dialysis session. There are currently no reports of overdose in patients. In healthy subjects, the use of tenofovir disoproxil fumarate 600 mg for 28 days without adverse events has been reported. However, if there is a case of drug overdose, the patient still needs to be closely monitored for symptoms of toxicity, if necessary, supportive treatments can be applied.
If you forget to take a dose of Tenfovix, the patient should take it as soon as possible. If it is almost time for your next dose, you can skip the missed dose and take your next dose at the scheduled time.
3. Tenfovix side effects
When using Tenfovix 300mg, patients may experience some side effects such as:
Common: Mild to moderate stomach upset with symptoms of anorexia, abdominal pain, diarrhea, flatulence, indigestion, vomiting and nausea. In addition, patients may experience dizziness, fatigue, skin rash, headache, hypophosphataemia; Rare: Pancreatitis, increased liver enzymes, increased plasma amylase levels, hepatitis; nephrotoxicity (Fanconi syndrome, interstitial nephritis, acute renal failure); lactic acidosis accompanied by liver enlargement and fatty liver; Decreased bone mineral density is a reported side effect in HIV-infected patients with a history of fracture or with risk factors for osteoporosis or bone loss; Fat accumulation, metabolic abnormalities such as hypercholesterolemia, hypertriglyceridemia, insulin resistance, hyperglycemia, increased creatine phosphokinase, myositis, myalgia. When experiencing side effects of the drug, the patient should notify the doctor for appropriate treatment instructions.
4. Be careful when using Tenfovix
Some precautions for patients to remember before and during use of Tenfovix:
Lactic acidosis, liver enlargement and fatty liver are symptoms reported when using tenofovir in combination with other antiretroviral drugs. The majority of cases are seen in women, especially if risk factors are obesity and prolonged nucleoside exposure. Therefore, caution should be exercised when Tenfovix is used in patients with risk factors for liver disease. The drug should be discontinued if there is an increase in aminotransferase levels, lactic acidosis or signs of liver toxicity; Carefully monitor renal function, especially in patients at risk, with a history of renal dysfunction in order to detect changes in serum creatinine and phosphate; HIV-infected patients should be tested for hepatitis B status prior to antiretroviral therapy. Tenfovix is not indicated for the treatment of hepatitis B. The efficacy and safety of the drug have not been established in patients co-infected with HIV and hepatitis B. In some cases, the drug has even been aggravated. symptoms of hepatitis B. Therefore, if possible, patients should begin treatment with hepatitis B before using Tenfovix to treat HIV infection; Tenfovix is not recommended for use in children under 18 years of age because its safety and effectiveness have not been established in this population; Tenfovix should be used during pregnancy only if clearly needed, after carefully weighing the benefits and risks with your doctor; Tenfovix may cause dizziness. If you feel dizzy while taking the drug, the patient should not drive or operate machinery; Tenfovix is contraindicated in lactating women.
5. Tenfovix drug interactions
Some drug interactions of Tenfovix include:
Concomitant use of Tenfovix with drugs that reduce renal function or drugs that compete with tenofovir for renal tubular secretion will increase the concentration of tenofovir and other drugs. Shared; Concomitant use of Tenfovix with lopinavir, atazanavir, ritonavir may increase tenofovir exposure. When using Tenfovix, patients should strictly follow all instructions given by their doctor about dosage, method of administration, and duration of taking the drug. If there are any unusual symptoms, the patient should immediately report to the doctor to receive appropriate advice.
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