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Strychnin belongs to the group of psychotropic drugs with the main ingredient Strychnine sulfate, which helps to support nerves and muscles and is effective in limb palsy, urinary incontinence, bladder colon, nerve paralysis, muscle fatigue, impotence. , the sick get up, stimulate digestion for the sick.1. What is Strychnin?
Strychnin drug has the main ingredient Strychnin sulfate, which is an alkaloid of the precursor seed that preferentially acts on the spinal cord by selective and competitive antagonism with glycin on the glycin receptor in the spinal cord, helping to stimulate the marrow reflex, increase nerve conduction and nutrition, muscle activity.
Strychnin drugs stimulate digestion, increase secretion of gastric juice and intestinal motility to help eat better and easier to digest. In addition, the drug Strychnin increases the sensitivity of the sensory organs by stimulating the hearing, vision, and smell centers. Strychnin drugs are usually indicated in the following cases:
To support nerves and muscles; Patients with limb palsy, urinary incontinence, bladder colon; Patients with neurological paralysis, muscle fatigue, impotence, the elderly get sick; Stimulating digestion for convalescents; Treatment of barbituric and stimulant hypnotic poisoning in open brain cases. The drug is contraindicated in patients with hypertension, arteriosclerosis, acute vasculitis, hepatitis, epilepsy, Tetanie and Graves' disease.
2. Dosage of the drug Strychnin
Strychnin is usually prepared as a solution for subcutaneous injection or intramuscular injection. Depending on the subject and the goal of treatment, the dose of Strychnin will be different, specifically as follows:
Subcutaneous injection, adults: 0.5-1mg/time x 2-3 times/day; Intramuscular injection: 1mg x 2 times/day; In neuropathy, the dose must be increased gradually, starting from 2mg, increasing by 1mg per day, gradually up to 5mg/day, then decreasing to 2mg per day to the initial dose; Maximum dose for adults: 2mg/time, 5mg/day; Maximum dose for children > 2 years old: 0.25mg/time; 0.5mg/day; Children < 2 years old should not take Strychnin. Strychnin overdose can cause poisoning after 15-30 minutes and lasts for many hours with symptoms such as:
Muscle spasticity, progressive muscle pain throughout the body forming a bent posture like tetanus ; Strychnin face: Contraction of facial muscles creates a scowl, uncomfortable and fixed face, the contraction of the oral muscles exposes both teeth to the outside; Symptoms of muscle contraction appear after a very mild stimulus to the body such as massage, examination; Hyperthermia, acute rhabdomyolysis, compartment compression, myoglobinuria and acute renal failure; At this time, the management of strychnine poisoning is mainly airway and respiratory control. In addition, it is necessary to treat hyperthermia and metabolic acidosis if present, and limit stimulation to the patient. After that, it is necessary to treat muscle spasticity, use measures to limit absorption (gastric lavage, activated charcoal) and measures to enhance elimination of toxins.
3. Strychnine side effects
In some patients when using Strychnin, the following side effects may occur:
Mild allergies such as rash, itching, redness of the skin; High doses can cause neurotoxicity due to overstimulation and even death from respiratory arrest. If you experience undesirable effects after using Strychnin, you need to stop using the drug immediately, in case of severe hypersensitivity or allergic reaction, you need to take supportive treatment such as keeping ventilation, breathing oxygen, taking antibiotics. Histamine, Corticosteroids, Epinephrine.
The article has provided information about what Strychnin is, dosage and precautions for use. To ensure safety for your health and maximize the effectiveness of treatment, you need to take Strychnin exactly as directed by your doctor, do not increase or decrease the dose or give prescriptions to others to use.
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