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Sprycel medicine has the main ingredient Dasatinib, which is made in tablet form. The drug is indicated in the treatment of leukemia and helps to reduce the growth of cancer cells. However, the drug Sprycel can cause some unwanted side effects, so patients need to follow the instructions of the treating doctor.
1. Mechanism of action of the drug Sprycel
Sprycel medicine contains a 100mg dasatinib compound that inhibits kinase activity. Kinases are an enzyme that promotes cell growth, and many types of kinases control different stages of cell growth. So blocking a specific enzyme from working will slow the growth of cancer cells.
Oncogenic and cell growth-promoting kinases include BCR-ABL kinase, SRC, c-KIT, ephrin receptor kinase EPH, PDGFb receptor.
Sprycel contains dasatinib which is a potent sub-monopolar inhibitor of the BCR-ABL kinase with potency concentrations ranging from 0.6 to 0.8 nM. This compound is in the form bound to both active and inactive BCR-ABL kinase enzyme.
2. What diseases does Sprycel treat?
Sprycel is indicated for the treatment of:
The patient is an adult who has just been diagnosed with chronic myeloid leukemia with the Ph+ chromosome. Subjects were adults with Ph+ and CML who no longer benefited or were intolerant of other treatments. Subjects were adults with acute lymphoblastic leukemia Ph+ and ALL that were no longer effective or intolerant of other regimens. Patients are children from 1 year old and have Ph+ in the chronic stage. Subjects are children aged 1 year and older with newly diagnosed Ph+ and ALL combined with chemotherapy. However, Sprycel may be contraindicated in cases of hypersensitivity to the components of the drug.
3. Dosage and usage of Sprycel
Sprycel can be used at a dose of 140mg once daily and at a once-in-a-lifetime basis for acute leukemia until disease progression becomes unacceptable.
For chronic leukemia, use Sprycel 100mg once a day. In case of gastrointestinal stromal tumor, use Sprycel at a dose of 70mg twice daily.
Sprycel is used in oral form, so it can be taken with or without food. However, patients should take the medicine at the same time of day to increase its effectiveness.
Blood levels of Sprycel can be affected by certain foods and patients should avoid using these drugs and foods at the same time. For example, grapefruit.
Moreover, Sprycel is best absorbed when there is acid in the stomach. Therefore, patients should not take drugs that reduce stomach acid, including proton pump inhibitors, H2 blockers, etc. In case of using drugs to lower stomach acid, they need to use drugs that have weight-balancing activities. Equalize the acid and then use Sprycel 2 hours after or before doing this.
Note: The above recommended therapeutic dose for Sprycel is for reference only. Therefore, before using Sprycel, patients need to be prescribed by a doctor.
If the patient has missed a dose of Sprycel, take the missed dose as soon as you remember. However, if the interval between the missed dose of Sprycel and the next dose is close, the patient can skip the missed dose and take the next dose. It should be noted that the double dose of Sprycel should not be used, because it can cause drug overdose and unwanted side effects that affect the patient's current health during treatment with Sprycel.
In case the patient accidentally takes an overdose of Sprycel than prescribed and has some signs of unwanted side effects, it is necessary to take the patient to an emergency at the nearest medical facility to receive treatment. timely medical support, and help the patient overcome the dangerous situation to ensure safety.
4. Some unwanted side effects and notes on using Sprycel
Sprycel can cause some unwanted side effects, but the extent of these reactions will depend on the individual. Specifically:
Nausea and vomiting may occur when using Reclast. You can tell your doctor to prescribe medication to help control the condition. In addition, the doctor may also prescribe appropriate dietary changes to improve the current medical condition. For example, the patient should avoid using foods that can aggravate these symptoms such as greasy, fatty or sour foods... Instead, the patient can use medication. antacids, saline, ginger ale to ease symptoms of nausea and vomiting. Diarrhea can occur in cancer cases. Therefore, your doctor may prescribe some medications to help relieve diarrhea. In addition, patients should eat low-fiber foods, boiled chicken, white rice, to limit diarrhea. Drink 8 to 10 glasses of water without alcohol or caffeine per day to limit dehydration. Anemia with a low number of red blood cells in the blood. Red blood cells carry oxygen to the body's tissues. But when the red blood cell count drops, the body can feel tired and weak. In addition, the patient also feels shortness of breath, chest pain... If the red blood cell count is too low, the patient needs a blood transfusion. Musculoskeletal and joint pain: Sprycel may cause moderate to severe musculoskeletal pain in patients. This can happen for about 1 day or a few months after using Sprycel. When experiencing these symptoms, the patient should notify the treating doctor to have a plan to relieve the pain. The patient is always in a state of fatigue: After cancer treatment, the patient always feels exhausted and this condition takes a long time to improve. Therefore, patients need to adjust as well as plan long-term rest, and at the same time save energy for important activities. In addition, the patient can do exercise to combat fatigue by walking, relaxing... Bleeding may occur when using Sprycel. If the patient experiences symptoms of bleeding, bruising or bright red bloody stools, ... it is necessary to notify the doctor for prompt medical assistance. Cardiovascular problems. Sprycel can cause an irregular heartbeat and, if prolonged, congestive heart failure or a heart attack. Pulmonary hypertension, caused by the drug Sprycel increases blood pressure in the pulmonary vessels, making the patient feel short of breath, tired, and swollen all over. Tumor lysis syndrome: Having a large amount of tumor cells in the body and using Sprycel may increase the risk of tumor lysis syndrome. Then the tumor cells die too quickly and their waste overwhelms the body. The drug can come into direct contact with the fetus and cause birth defects. Therefore, women who are pregnant or who are planning to become pregnant should not use Sprycel. Above is information about the drug Sprycel . To use Sprycel safely and effectively, patients need to carefully read the instructions for use, consult a doctor before use.
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Reference source: oncolink.org
