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Sopelen tablets 500mg are used in the treatment of consciousness disorders after brain surgery or due to head trauma, supporting movement recovery in patients with hemiplegia due to cerebrovascular accident and Parkinson's disease with severe tremor symptoms. . The following article provides you with information about the uses, dosage and precautions when using Sopelen tab 500mg.1. The effect of the drug Sopelen tab 500mg
Sopelen tab film coated tablets contain Sodium Citicolin equivalent to 500mg Citicolin. Other excipients of the drug include: Microcrystalline cellulose; croscarmellose sodium; carboxymethylcellulose; colloidal silicon dioxide; sodium lauryl sulfate; hydrogenated castor oil; magnesium stearate; talc; titanium oxide; butyl-2-dimethylaminoethyl, polyethylene glycol; methyl methacrylate copolymer (1:2:1).Citicolin is a biological mediator of lipid synthesis. Citicolin is a precursor for the synthesis of lecithin - one of the major components of the cellular and humoral arrays of organs.
Through the role of lecithin in regeneration, it has been shown that the use of Citicolin has pharmacological effects on the central nervous system, protecting the central nervous system against many toxic substances (organic solvents toxic to the nervous system. neuropathy, hypoxia)
Research shows that there is a correlation between brain damage and neurological dysfunction and phospholipid deficiency in the diseased area. In addition, phospholipid remodeling requires the incorporation of choline into phosphatidylcholine, which needs to be done via citicolin. Therefore, citicolin is used in the treatment of neurological dysfunction in old age (fatigue, dizziness, migraine, memory loss, insomnia, decreased physical strength, postural disorders, and dysfunctions in function). social interaction), postoperative brain damage, and cerebrovascular thrombosis.
2. Pharmacokinetic properties of Sopelen tab 500mg
Citicolin is a water-soluble compound with more than 90% bioavailability. Pharmacokinetic studies using Citicolin in healthy adults have shown that an oral dose of Citicolin is rapidly absorbed, <1% excreted in the feces. Peak Citicoline concentrations are achieved at two time points: 1 hour and 24 hours after dosing, Citicolin is metabolized in the intestinal wall and liver. The by-products of exogenous Citicolin formed by hydrolysis in the intestinal wall are choline and cytidine. After absorption, choline and cytidine are dispersed throughout the body, enter the systemic circulation, and are used in various biosynthetic pathways. Choline and cytidine cross the blood-brain barrier to resynthesize into citicolin in the brain.3. Indications and contraindications for using Sopelen tab 500mg
3.1. Point
Disturbance of consciousness after brain surgery or due to head trauma. Support movement recovery in patients with hemiplegia due to cerebrovascular accident. Parkinson's disease is characterized by severe tremors.3.2. Contraindications
Allergy or hypersensitivity to Citicolin or any of its ingredients. Pregnant women. Women who are breastfeeding.4. How to take Sopelen tab 500mg
Sopelen tab is taken orally. Usual dose: 1-2 tablets/day.Consciousness disorder after brain surgery or head trauma: 1 tablet/time x 1-2 times/day. Support movement recovery in patients with hemiplegia due to cerebrovascular accident: 2 tablets/time/day for 3-4 weeks. Parkinson's disease with severe tremor symptoms: 1 tablet / time / day for 3-4 weeks.
5. Overdose of Sopelen tab and treatment
Overdose of Sopelen 500mg can cause low blood pressure, dizziness, loss of appetite, nausea, vomiting, diarrhea, increased salivation, constipation, sweating and headache.If any symptoms appear during treatment, stop using Sopelen tab and go to a medical facility for timely treatment.
6. Notes when using Sopelen tab 500mg
Sopelen tab is considered safe and well tolerated. Contraindicated to use Sopelen tab 500mg for pregnant and lactating women. Citicoline may trigger pre-existing epilepsy in patients. Dosage of Sopelen tab in the upper limit is contraindicated in patients with trimethylamine in the urine, kidney or liver disease, Parkinson's disease. Ability to drive and use machines: Sopelen tab may have some effects on the ability to drive and use machines. Use caution when using this drug.7. Undesirable effects when using Sopelen tab
In some cases, patients may experience the following undesirable symptoms: mild disturbances in the gastrointestinal tract, epigastric pain, nausea, vomiting, diarrhea; fatigue, headache, agitation. Occasionally patients may experience hypotension with bradycardia, tachycardia. Inform your doctor about the unwanted effects encountered when taking Sopelen tab 500mg.8. Drug interactions
Do not take Sopelen tab 500mg and Meclofenoxate or Centrofenoxin at the same time. Citicolin increases the potency of Levodopa, caution should be exercised when combining these two drugs.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
