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Shinapril belongs to the group of cardiovascular drugs with the main ingredient Enalapril maleate 10mg. This medication is used to treat high blood pressure and diabetes. The following article would like to share with readers the use and effective use of Shinapril.1. What does Shinapril do?
What does Shinapril do? Shinapril is used in the following cases:Treatment of mild to severe idiopathic hypertension. Treatment of hypertension due to kidney disease. Treatment of hypertension with diabetes. Treatment of heart failure levels such as: slowing the progression of heart failure, improving survival and reducing the number of myocardial infarctions. Treatment and support to prevent congestive heart failure. Support to prevent ventricular dilatation after myocardial infarction.
2. Dosage - How to take Shinapril
Shinapril is made in the form of tablets and taken orally. The drug can be taken before or after a meal or food without changing the bioavailability of Shinapril. Use 1 to 2 doses per day.
The dose of Shinapril drug depends on the disease condition and the object of treatment.
Primary hypertension:
Starting dose of 5mg Enalapril, may increase dose depending on the degree of hypertension, maintenance dose is determined after 2-4 weeks of treatment. The daily dose is 10 to 40 mg of Enalapril, taken once a day or in two divided doses. The maximum dose is 40 mg Enalapril/day. It is advisable to start at a low dose because of the potential for symptomatic hypotension, and should not be used concurrently with diuretics. In case of renal failure:
Creatinine clearance 30 - 80 ml / min, dose 5 - 10 mg Enalapril / day. Creatinine clearance 10-30 ml/min, dose 2.5-5 mg Enalapril/day. Heart failure:
Usually in combination with digitalis and diuretics (diuretics should be reduced and spaced before Enalapril).
An initial dose of 2.5 mg, which can be gradually increased to a therapeutic dose, must be done under careful monitoring.
3. Contraindications to using Shinapril
Shinapril should not be used in the following cases:
Patients with hypersensitivity or history of allergy to Enalapril or to any of its ingredients. Angioedema. Bilateral renal artery stenosis and renal artery stenosis in a person with only one kidney. Aortic stenosis and severe obstructive cardiomyopathy. Pre-existing hypotension. Pregnant women.
4. Shinapril drug interactions
Shinapril when combined with some other drugs may have drug interactions with each other, patients should not take enalapril at the same time. In this case, the doctor may change the dose or take necessary measures.
If you are taking enalapril, you should tell your doctor or pharmacist about other medicines you may be taking, especially the following:
Diuretics Potassium supplements Antiretroviral drugs Other hypertension Drugs Lithium Tricyclic antidepressants Antipsychotics Anesthetics, narcotics Non-steroidal anti-inflammatory drugs Sympathomimetic drugs Diabetic drugs Acetylsalicylic acid Drugs Thrombolytics Drugs beta blockers and alcohol.
5. What side effects does Shinapril cause during use?
During the use of Shinapril, patients may experience some unwanted side effects as follows:
Blood and lymphatic system disorders: Anemia, neutropenia, decreased hemoglobin, anemia aplasia and hemolytic anemia, decreased haematocrit, thrombocytopenia, agranulocytosis, autoimmune disease, bone marrow suppression, pancytopenia, lymphoma. Nutritional disorders: hypoglycemia. Nervous system and mental disorders: Depression, headache, confusion, insomnia, somnolence, irritability, paresthesia, dizziness, sleep disturbances, abnormal dreams. Eye disorders: blurred vision. Cardiovascular disorders: Hypotension, orthostatic hypotension, dizziness, syncope, chest tightness, myocardial infarction, tachycardia, cerebrovascular accident, arrhythmia, angina, Raynaud's phenomenon, palpitations. Respiratory tract disorders: dyspnea, hoarseness, cough, rhinorrhea, pharyngitis, rhinitis, bronchospasm, asthma, pulmonary infiltrates, allergic alveolitis, eosinophilic pneumonia. Gastrointestinal disorders: nausea and vomiting, abdominal pain, diarrhea, constipation, taste changes, intestinal obstruction, pancreatitis, mouth sores, dyspepsia, loss of appetite, stomach irritation, dysphagia, ulcers stomach, aphthous, glomerulonephritis. Hepatobiliary disorders: jaundice + cholestasis, liver failure, hepatitis Subcutaneous tissue and skin disorders: Hypersensitivity reactions, rash, angioedema, pruritus, alopecia, urticaria, erythema multiforme , exfoliative eczema, Stevens-Johnson syndrome, toxic epidermolysis bullosa, pemphigoid erythema. Fever, vasculitis, serosa, myalgia, arthralgia, myositis, arthritis, ANA positive, oliguria, eosinophilia, leukocytosis, renal failure, proteinuria. Reproductive system: gynecomastia in men, impotence. Other disorders: fatigue, weakness, cramps, flushing, tinnitus, dizziness. Laboratory abnormalities: increased plasma creatinine, hyperkalemia, uremia, hypernatremia, increased plasma bilirubin, increased liver enzymes. Patients should inform their doctor or pharmacist of any adverse effects encountered while taking Shinapril.
6. Precautions when using Shinapril
Patients should carefully refer to the instruction sheet for using Shinapril listed on the product packaging or as directed on the prescription of a doctor or pharmacist. In addition, patients can refer to some of the following notes when using Shinapril.
In hypertensive patients receiving enalapril, symptomatic hypotension may occur if the patient is volume-depleted. Enalapril must be used with caution in patients with left ventricular septal defect, cardiogenic shock, and hemodynamic obstruction. In case of renal failure, the starting dose of Enalapril must be adjusted according to the creatinine clearance and the patient's response to treatment. Therefore, it is necessary to closely and regularly control creatinine and potassium. The risk of hypotension and renal failure is increased in patients with bilateral renal artery stenosis or narrowing of the artery to a functioning kidney. Neutropenia/granulocytopenia, thrombocytopenia, and anemia have been reported in patients receiving ACE inhibitors. Enalapril must be used with caution in people with collagen vascular disease, treatment with allopurinol or procainamide, immunosuppressive therapy, or a combination of these complicating factors. Angioedema of the face, lips, tongue, glottis and/or pharynx has been reported in patients treated with ACE inhibitors. Anaphylactic reactions have been reported rarely in patients receiving ACE inhibitors during desensitization with snake venom. Anaphylaxis has been reported in patients on high-velocity membrane dialysis and concomitant treatment with ACE inhibitors. In diabetic patients treated with insulin or oral antidiabetic agents, blood glucose levels should be closely monitored during the first month of ACE inhibitor therapy. There have been reports of patients with dry cough while taking Shinapril drugs. There have been cases of hypotension during surgery or anesthesia in patients taking ACE inhibitors. Hyperkalemia has been reported in patients taking ACE inhibitors. Co-administration of enalapril with lithium should not be combined. If the patient has a history of intolerance to certain sugars, the drug should not be used. Do not take Shinapril during pregnancy. Shinapril is excreted in human milk; however, there are no data on whether the drug affects the neonate or not. Therefore, pregnant women should not take the drug while breastfeeding. Sometimes Shinapril is dizzy and tired, so users should also be careful when driving and operating machinery Shinapril belongs to the group of cardiovascular drugs with the main ingredient being Enalapril maleate 10mg. This medication is used to treat high blood pressure and diabetes. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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