Uses of Semiflit 120

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1. What is Semiflit 120?

Manufacturer: Pymepharco Joint Stock Company - Vietnam
Packing: Box of 2 blisters x 21 tablets.
Dosage form: Hard capsule.
Main ingredients:
Orlistat 120 mg. Excipients are sufficient.

2. Uses of Semiflit 120

Drug effects
Orlistat effects:
Orlistat is a reversible inhibitor of Lipase enzymes. Inactivation of Lipase enzyme, causing inability to hydrolyze fats in the form of Triglycerides into free fatty acids and monoglycerides, making them unabsorbed by the body. The Triglycerides are not absorbed, causing a calorie deficit, effectively reducing excess fat. At a dose of 120 mg 3 times a day, Orlistat inhibited about 30% of the absorption of fat in food. Indication
Semiflit 120 is used to support fat loss with a low-calorie diet in overweight (BMI ≥ 28kg/m2), obese (BMI ≥ 30kg/m2) patients with risk factors such as diabetes sugar, high blood pressure, hyperlipidemia.
How to use - Dosage
How to use:
Drink with water just before, while eating or 1 hour after the main meal. If you miss a meal or a meal without fat, you may not need to take the medicine. Dosage:
The drug is taken according to the instructions of the doctor. You can refer to the following dosage for adults: 1 tablet / time, 3 times / day. Doses exceeding 1 tablet/time, 3 times daily do not increase benefit. How to handle missed dose and overdosage
Missed dose:
Take medicine as soon as you remember. If it is far from the usual time of taking the medicine, you can skip the missed dose and take the next day's normal dose. Do not take 2 doses at the same time. If you miss a dose but miss a meal or the meal does not contain fat, skip the missed dose and take the next dose as usual. Overdose:
Trials of 800mg/day and 400mg x 3 times/day for 15 days in normal weight or obese subjects did not find significant side effects. In case of overdose, the patient should be monitored and monitored for 24 hours. The systemic effects related to the lipase inhibitory properties of Orlistat should be rapidly reversible.

3. Side effects of Semiflit 120

Common side effects while taking the drug that have been reported as gastrointestinal disturbances include urgency to have a bowel movement, bowel incontinence, flatulence, and fatty stools. These symptoms can be minimized by limiting the amount of fat in the meal. Other side effects reported: Headache, anxiety, fatigue and menstrual irregularities. There have been cases of hypertension when taking Orlistat, blood pressure will decrease when the drug is stopped and increase again after taking it. Inform your doctor if any adverse reactions occur.

4. Drug interactions

Drug interactions that need attention when combining drugs in treatment:
Ciclosporin: Orlistat reduces the concentration of Ciclosporin in the blood plasma. Acarbose: There are no pharmacokinetic interaction studies, avoid concomitant use of Orlistat and Acarbose. Fat-soluble vitamins: Drugs that reduce the absorption of fat-soluble vitamins (A, D, E, and K). Therefore, during long-term treatment, it is necessary to take supplements of the above vitamins. However, it should be taken 2 hours before or after taking the medicine or before going to bed. Oral anticoagulants such as Warfarin or other anticoagulants: International normalized ratio (INR) should be monitored.

5. Note when using Semiflit 120

Contraindications
Do not use Semiflit 120 for the following cases:
Hypersensitivity to Orlistat or any of its ingredients. Chronic malabsorption syndrome or cholestasis. Note
Use on pregnant women and nursing mothers
There are no adequate reports on the effects of the drug when used in pregnant women. The drug is not recommended for these subjects. It is not known whether the drug is excreted in human milk. The drug should not be used in lactating women. Driving and operating machinery
The drug can cause headaches and anxiety. Use caution when driving and operating machinery.
Other special note
Caution when used for people with a history of hyperoxaluria or calcium oxalate kidney stones. After weight loss, patients with type 2 diabetes need to adjust the dose of their hypoglycemic agents because of improved metabolic control. Estrogen potency may be reduced in cases where Orlistat causes severe diarrhea. It is recommended to use additional supportive methods of contraception. Storage
The drug is stored in a cool, dry place, away from sunlight. The temperature should not exceed 30 degrees Celsius. Keep out of reach of children.

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