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Salbucare has the main ingredient Salbutamol, which belongs to the group of drugs called β2 Adrenergic receptor agonists. Salbucare is used in the treatment of bronchial smooth muscle spasms. Knowing the basic information about the ingredients, uses, doses and unwanted effects of Salbucare medicine will help patients and their loved ones improve treatment results.1. What is Salbucare?
Salbucare medicine is prepared in the form of oral syrup in a 60 ml bottle, with the main ingredients including:
Active ingredient: Salbutamol (in the form of Salbutamol Sulfate) content 2 mg/5 ml. Excipients: Just enough for 1 bottle of 60 ml. Salbutamol stimulates Β-Adrenergic receptors, is more specific on β2 Adrenergic than isoprenaline and has little or no effect on α receptors. β-agonists such as salbutamol stimulate the production of cAMP, mediators of many cellular responses, through the activation of the enzyme adenylcyclase. Increasing the concentration of cAMP in the cell increases the activity of Protein Kinase A (cAMP dependent), thereby inhibiting the actin - Myosin binding Phosphorylation in smooth muscle and reducing the concentration of Ca++ in the cell, leading to relaxation smooth muscle of the bronchi as well as of the uterus and blood vessels. Similar mechanisms of salbutamol promote glycogenolysis and insulin release. In addition, increasing the concentration of cAMP in cells also prevents the release of SRS-A, Histamine and other mediators of allergic response from mast cells, so Salbutamol also has antiallergic effects.
2. Effects of Salbucare
Salbucare is indicated for treatment in the following cases:
Treatment of symptoms of an acute asthma attack. Treatment of symptoms of bronchospasm in chronic bronchitis, emphysema. Treatment of symptoms during exacerbations of asthma or reversible chronic obstructive pulmonary disease (COPD). Prevention of exercise-induced asthma attacks. Pulmonary function test : Check for reversibility of blocked bronchi. However, in the following cases, the drug Salbucare is not allowed to prescribe:
Hypersensitivity to any ingredient of Salbucare medicine. History of allergy to other drugs containing the active ingredient Salbutamol. History of allergy to other drugs containing active ingredients that stimulate Β-Adrenergic receptors, especially β2 Adrenergic. Patients with a history of or current severe cardiovascular disease such as ischemic heart disease, or risk factors for exacerbation of ischemic heart disease. Patients with a history or current medical conditions such as hypercalcemia, renal failure, diabetes mellitus, hypokalemia, thyrotoxicosis, severe or uncontrolled hypertension. Preeclampsia, eclampsia. Used in combination with Ipratropium bromide in patients with a history of allergy to soy lecithin, foods related to peanuts, soy. The patient is being treated with an MAOI drug.
3. Dosage and how to use Salbucare
Salbucare oral syrup is suitable for children or adults who prefer to use medicine in liquid form.
Dosage in adults or children > 12 years old
Recommended dose: Take 10 ml (4 mg)/time x 3-4 times/day. Increase dose: Take 20 ml (8 mg)/time x 3-4 times/day if bronchodilator effect is not achieved. Reduce dose: Take 5 ml (2 mg)/time x 3-4 times/day if the patient responds to the bronchodilator effect. Dosage in children
Children 2 - 6 years old: Take 2.5 - 5 ml (1 - 2 mg)/time x 3 - 4 times/day. Children 6 - 12 years old: Take 5-10 ml (2 - 4 mg)/time x 3 - 4 times/day. Dosage in the elderly
Recommended dose: Take 5 ml (2 mg)/time x 3-4 times/day.
4. Side effects encountered when using Salbucare
Using Salbucare in high doses or for a long time, side effects may occur such as:
Common: Tachycardia, palpitations, headache, sweating, tremor especially in the hands. Uncommon: Gastrointestinal disturbances such as nausea, vomiting, anorexia. Systemic symptoms such as restlessness, insomnia, dizziness, dizziness. Cramp. Rare: Allergic reactions such as angioedema, urticaria, hypotension, bronchospasm, cardiovascular collapse, severe may lead to anaphylaxis. Metabolic disorders such as transient hyperglycemia, hypokalemia. Muscle tension, peripheral vasodilation, arrhythmias such as atrial fibrillation, extrasystoles, supraventricular tachycardia, hyperactivity. Patients should stop taking the drug when detecting the above side effects or other unusual symptoms after taking Salbucare, and promptly inform the treating doctor about the use of Salbucare, please go to the medical facility immediately. nearest to be treated promptly.
5. Note the use of Salbucare
Salbucare should be used with caution in patients with a history of or hypersensitivity to sympathomimetic amines, diabetes mellitus, hyperthyroidism, epilepsy, cardiovascular disease including arrhythmias, coronary insufficiency. , hypertension Pregnant women: The US Food and Drug Administration (FDA) has not classified the risk of using salbutamol in pregnancy, and the relationship between salbutamol use and the occurrence of malformations. birth button has not been determined. In some clinical cases, the use of salbutamol during pregnancy may increase fetal and maternal heart rate or may cause uterine atony. Therefore, caution should be exercised when using Salbucare in pregnant women. Lactation: Some reports have suggested that salbutamol can pass into breast milk and may cause a nursing infant to increase blood glucose and heart rate. Therefore, the use of Salbucare should be limited to nursing women, unless the expected benefit to the mother outweighs any potential risk to the baby. Drivers or machine operators often experience unwanted effects such as restlessness, insomnia, dizziness, dizziness... after using Salbucare. Therefore, avoid using Salbucare before and during work.
6. Salbucare drug interactions
Interactions with other drugs
Atomoxetin increases the risk of cardiovascular side effects of Salbucare. Salbucare reduces the concentration of Digoxin in the blood plasma. Using Salbucare with Methyldopa can cause an acute drop in blood pressure. Using Salbucare with drugs such as Corticosteroids, loop diuretics, Thiazides, Theophylline, Acetazolamide increases the risk of hypokalemia. Above is the necessary information about ingredients, indications, contraindications, dosage, usage and notes when using Salbucare. Patients and relatives should carefully read the instructions for use of Salbucare, and strictly follow the instructions of the treating doctor to achieve the best treatment effect.
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