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Rumacerin Cap has the main active ingredient is Diacerhein with the strength of 50mg and other excipients in sufficient quantity. Rumacerin Cap belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of bone and joint diseases.
1. What is Rumacerin Cap?
What is Rumacerin Cap? The drug Rumacerin Cap has the main active ingredient is Diacerhein with the strength of 50mg and other excipients in a sufficient amount. Rumacerin Cap belongs to the group of analgesics, antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of bone and joint diseases.
Rumacerin Cap is made in the form of hard capsules, suitable for direct oral use. Packing is a medicine box of 3 blisters, each blister contains 10 capsules or a box of 10 blisters, each blister contains 10 capsules.
1.1. Pharmacodynamics of the main active ingredient Diacerhein Active ingredient Diacerhein is a new anti-osteoarthritis drug with anti-inflammatory effects to treat degenerative joint diseases, specifically osteoarthritis and related diseases. The drug is well tolerated in the stomach, as it does not inhibit prostaglandin synthesis. The active ingredient Diacerhein is unique among existing osteoarthritis drugs that have the ability to affect the anabolism and catabolism of chondrocytes, and at the same time reduce proinflammatory factors.
1.2. Pharmacokinetics of the active ingredient Diacerhein After taking the drug with a dose of 50mg, the drug concentration peaked at 3mg/l after 2 to 3 hours, 99% of the active ingredient Diacerein bound to plasma proteins.
Metabolism: The mean half-life is about 4-5 hours. In the human body, this active substance is completely converted to Rhein (its active metabolite) through Sulfo and Glucuronic conjugation. Elimination: The active substance and active metabolite of the drug, is excreted in the urine 80% in conjugated form, 20% unchanged. 1.3. The effect of active ingredient Diacerhein Active ingredient Diacerhein reduces damage to bones, cartilage and synovial membrane in bone and joint diseases, protects artificially implanted cartilage grafts. In addition, this active ingredient also inhibits the activation and migration of white blood cells, causing anti-inflammatory effects. Different from non-steroidal anti-inflammatory analgesics or other NSAID groups, the active ingredient Diacerein has the ability to stimulate the synthesis of Prostaglandin, especially PGF-2 alpha, which enhances the protection of the gastric mucosa.
2. What disease does Rumacerin Cap treat?
Rumacerin Cap is used in the treatment of the following diseases:
Treatment of signs and symptoms of osteoarthritis. Oral treatment with pathologies such as osteoarthritis, osteoarthritis.
3. Usage and dosage of Rumacerin Cap
3.1. How to use Rumacerin Cap Rumacerin Cap is made in the form of hard capsules, suitable for direct oral use. When taking Rumacerin Cap, you need to swallow the tablet whole with enough water, do not chew or split the capsule. Rumacerin Cap does not cause stomach ulcers, so it can be taken before, during or after meals. However, you should take the medicine at the time of the meal, because food increases the absorption of the drug. 3.2. Dosage of the drug Rumacerin Cap Dosage of the drug as required by the doctor treating the disease. Specific reference treatment doses are as follows:
Initial treatment dose is 1 tablet/time x 1 time/day in the evening for about 2-4 weeks. Maintenance treatment dose: take 1 tablet / time x 2 times / day in two main meals for a long time. However, because the active ingredient Diacerein can rapidly increase the time it takes for food to pass through the intestines during the first 2 weeks of treatment, treatment should be initiated with 1 capsule of Diacerein taken daily with the evening meal for 2 weeks. Once you get used to this medicine, your doctor will gradually increase the dose to 2 Diacerein capsules per day. Your doctor will decide how long the treatment will take to be effective. However, because the active ingredient Diacerein has a slow onset of action and beneficial effects after 2 to 4 weeks of treatment, users should be encouraged not to discontinue treatment before its effects are evident. Cause Diacerein does not inhibit prostaglandin synthesis, it is not harmful to the stomach, so doctors can safely prescribe a non-steroidal anti-inflammatory drug (NSAID) during the first 2-4 weeks of treatment. . It should be noted: The above drug dosage is for reference only, the specific dose will depend on each person's condition and ability to respond to the drug. Therefore, the patient should take the drug exactly as directed by the doctor or pharmacist.
3.3. How to deal with missed dose, overdose of Rumacerin Cap In case of missed dose: Take up the therapeutic dose as soon as you remember. You should note that absolutely do not make up for a double dose or take 2 doses close to each other because it can cause an overdose. Overdose: You may experience signs and symptoms such as massive diarrhea. The way to handle it is that you need to immediately contact the treating doctor or go to the nearest medical facility for timely and proper treatment.
4. Undesirable effects of the drug Rumacerin Cap
Common undesirable effects when treated with Rumacerin Cap are the rapid increase in intestinal transit time and abdominal pain. These signs and symptoms may appear within the first few days of treatment and in most cases, they resolve spontaneously with continued treatment.
In addition, the use of drugs containing the active ingredient Diacerein can make the urine darker yellow. Inform the doctor to treat the unwanted effects encountered when using Rumacerin Cap.
5. Interactions of Rumacerin Cap
Interactions of Rumacerin Cap drugs that may occur during use are as follows:
Studies show that the drug does not cause adverse interactions when co-administered with Rumacerin Cap with drugs such as Warfarin, Indomethacin, Aspirin, Tolbutamide , Chlorprothamine. Rumacerin Cap should not be used concurrently with laxatives. The reason is that laxatives can reduce the therapeutic effect of Rumacerin cap 50mg. Concomitant administration of Rumacerin 50mg with medicinal products containing salts, oxides or hydroxides of aluminum, calcium and magnesium should be avoided. This is because they reduce the absorption of the active ingredient Diacerein. You can take these substances at a different time more than 2 hours after taking Rumacerin cap 50mg. To ensure safety, you should actively list with your treating doctor all medications, health foods and medical history to avoid interactions that are detrimental to your health. .
6. Some notes when using Rumacerin Cap
6.1. Contraindications of the drug Rumacerin Cap People with a history of hypersensitivity to the active ingredient Diacerein and its components. Diacerein should not be used in people with known hypersensitivity to the drug or its excipients or those with a history of hypersensitivity to the components of Anthraquinone derivatives. 6.2. Notes and Precautions for Rumacerin Cap The benefits against the risks of administering Diacerein should be weighed against those with pre-existing intestinal disorders, especially irritable colon. Medicines containing the active ingredient Diacerein should not be prescribed to children under 15 years of age, as there are no clinical studies in this age group. Use for pregnant and lactating women: Rumacerin cap 50mg should not be used by pregnant women. In addition, Rumacerin 50 mg should not be prescribed to a nursing woman, as it has been reported that small amounts of diacerein derivatives pass into breast milk. Using the drug for drivers and operating machines: There have been no reports of harmful effects of Rumacerin cap 50mg on the ability to concentrate while driving or operating machinery and equipment. 6.3. Other special note Rumacerin cap 50mg should be used continuously for at least 6 months for the best treatment effect. If taking Rumacerin cap 50mg continuously for a long time, the doctor may order to check the laboratory indicators, including liver enzymes, every 6 months. 6.4. Storage conditions Store the medicine at a temperature below 30°C, away from direct sunlight. Keep medicine out of reach of children and pets. Absolutely do not use the drug Rumacerin cap 50mg after seeing the expiry date printed on the packaging of the medicine. Above is all information about Rumacerin Cap, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Rumacerin Cap to treat the disease at home, because there may be unwanted side effects to health.
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