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Raciper 40mg drug is made in the form of tablets. The drug has the main ingredient Esomeprazole magnesium 40mg, belongs to the group of gastrointestinal drugs. The drug is used to treat benign gastric and duodenal ulcers effectively.
1. Effects and uses of Raciper 40mg
Esomeprazole is an S-isomer of omeprazole, which is responsible for reducing gastric acid secretion by a specific mechanism of action. Raciper is a specific inhibitor of the acid pump in parietal cells. The two isomers, R- and S-, of omeprazole have similar pharmacodynamic effects. Site and mechanism of action of the active ingredient Esomeprazole is a weak alkaline substance and is concentrated and converted to an active form. Acts in a highly acidic environment in the urinary tract to inhibit parietal cell secretion. In the tubules, Raciper inhibits the enzyme H+K+-ATPase and both basal and stimulated secretions.After 5 days of taking oral doses of Raciper 20mg and Raciper 40mg, the pH in the stomach is > 4 and maintained for a period of 13, 17 hours within 24 hours in patients with gastroesophageal reflux disease. This effect is similar for oral and intravenous administration. When taking Raciper 40mg orally, up to 78% of patients with reflux esophagitis were cured after 4 weeks and 93% were cured after 8 weeks. Disease manifestations such as: erosive esophagitis, esophageal stricture, esophageal ulcer. Prevention and treatment of benign gastric and duodenal ulcers. Zollinger-Ellison syndrome.
2. How to use and dose Raciper
Raciper 40mg should be taken on an empty stomach and 1 hour before meals. Tablets should be swallowed whole and should not be chewed/crushed. However, in case of inability to swallow, the tablet can be dispersed in non-carbonated water and administered through a nasogastric tube.
Dosage:
For the treatment of gastric and duodenal ulcers when infected with Helicobacter pylori: The maximum dose is 1 Raciper 40mg tablet/day/time. If combined with Clarithromycin 500mg and Amoxicillin 1g, take 2 times a day. The course of treatment with Raciper only lasted 10 days. With treatment of Zollinger Ellison syndrome: Depending on the degree of increased acid secretion in the stomach, the oral dose is usually higher than other cases and can be taken once or divided into several times. If the patient does not have the tumor removed, long-term medication will be required. In case of treatment of gastroesophageal reflux disease, severe esophagitis with esophagitis: The maximum dose is 1 tablet / time / time, taken once a day and in about 4 to 8 weeks can be increased if internal medicine is used. still have symptoms or inflammation.
3. Raciper side effects
In the process of using Esomeprazole will encounter some side effects, but not every individual when using the drug also encounters side effects.
Common:
Headache. Abdominal pain Constipation Diarrhea Nausea/vomiting Uncommon:
Peripheral edema Insomnia Dizziness, paresthesia and somnolence Dry mouth Increased liver enzymes Dermatitis, rash, urticaria, itching Hip fracture Wrist fracture Rare:
Leukopenia/platelets Hypersensitivity reactions: fever, anaphylaxis, angioedema hyponatremia Agitation, confusion, depression Taste disturbances Blurred vision Dizziness Bronchospasm Stomatitis and gastrointestinal candidiasis. Hepatitis Hair Loss Sensitivity to light Arthralgia, myalgia Interstitial nephritis Difficulty, increased sweating.
4. Notes and cautions when using Raciper 40mg
Here are the notes before taking Raciper 40mg.
In the case of the elderly, pregnant and lactating women should not use atazanavir. You need to fully inform your doctor, pharmacist about your current medical condition, history of allergies, whether or not you are pregnant and breastfeeding. Before using the drug, you need to carefully read the directions of the leaflet first, to avoid the harmful effects of the drug. When you are pregnant and taking Raciper, you should consult with your doctor, pharmacist to weigh the benefits and risks before taking the drug. In case of breast-feeding: it is generally not recommended to use the drug. Therefore, the mother will have to carefully consider taking the drug while breastfeeding. Use Raciper 40mg for the elderly need to be very cautious. Because at this age the sensitivity to the drug may be greater than that of the average adult. You need to carefully read the dietary notes printed on the leaflet.
5. Raciper drug interactions
When Raciper is combined with two or more other drugs at the same time, drug interactions often lead to antagonism or synergism.
Interactions with other drugs
Combining Raciper with pH-dependent absorbed drugs such as: Ketoconazole, iron salts and digoxin drugs increases gastric pH by inhibiting acid secretion, affecting the bioavailability of these drugs. . Esomeprazole and 14-hydroxy clarithromycin blood levels may be increased when esomeprazole, clarithromycin and amoxicillin are used concomitantly. Esomeprazole pharmacokinetic interaction with drugs metabolised by the cytochrome P450 enzyme system, isoenzyme CYP2C19 in the liver. Concomitant administration of esomeprazole and diazepam resulted in a 45% decrease in clearance of diazepam. Raciper drug interaction with food and drink
Using Raciper 40mg drug in combination with foods or alcohol, beer, tobacco... can affect the phenomenon of antagonism or synergism with the drug because it contains other active ingredients in the above foods and beverages.
You should read carefully the instructions for use of the medicine in the medicine box, or you can consult a doctor, pharmacist, who has expertise in taking Raciper 40mg with food, alcohol and tobacco.
The information about the drug Raciper 40mg, is not a substitute for the advice of a doctor, pharmacist. Therefore, the safest way for patients is to consult a professional before using.
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