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Pythinam contains a mixture of antibiotics Imipenem and Cilastatin, effective in the treatment of severe infections and hospital-acquired infections. However, medication is not the first choice in treating bacterial infections.
1. What are the effects of Pythinam?
Each bottle of Pythinam contains the following active ingredients:
lmipenem 500mg; Cilastatin 500mg content; Excipients Sodium bicarbonate. Effects of the main ingredients in the drug Pythinam:
Imipenem - Cilastatin belongs to the group of broad-spectrum Beta-lactam antibiotics, prepared in the form of intravenous infusion only. Cilastatin has a specific enzyme inhibitory effect, which inhibits the metabolism of Imipenem in the kidney, thereby increasing the concentration of unchanged Imipenem in the urinary tract. Imipenem has a broad antibacterial spectrum, bactericidal activity against most gram-negative and positive bacteria, including both aerobic and anaerobic.
2. Indications for the use of Pythinam
Pythinam is prescribed by a doctor in the following cases:
Treatment of sepsis; Skin and soft tissue infections; Urinary tract infections - genitourinary; Bacterial infection in the abdomen; Lower respiratory tract infections; Gynecological infections; Bone and joint infections ; Endocarditis ; Prevention of infection after surgery.
3. How to take Pythinam
How to use Pythinam:
Pythinam is used for intravenous infusion. Dosage of Pythinam:
Treatment of infections caused by sensitive bacteria: Intravenous infusion, adults with a dose of 1 - 2 g / day (divided into 3-4 times); Treatment of infections caused by desensitized bacteria, up to 50 mg/kg/day in adults (maximum dose 4 g/day); For children over 3 months old, taking Pythinam at a dose of 60 mg/kg/day (maximum dose of 2 g/day) divided into 4 times; Children weighing over 40 kg take the same dose as adults. Adults Prevention of infection: IV infusion of 1000 mg at the start of anesthesia and 1000 mg 3 hours later. Renal impairment: Use dose not more than 2g/day.
4. Contraindications to the use of Pythinam
Pythinam injection should not be used for subjects who are hypersensitive to the ingredients in the drug.
5. Undesirable effects when using Pythinam
Common side effects of Pythinam:
Nausea and vomiting; Diarrhea. Inflammation of the veins. Rare side effects when using Pythinam:
Lower blood pressure and palpitations. Epilepsy. Red rash. Pseudomembranous colitis. Decreased neutrophils, platelets but increased eosinophils. Anemia, prolongation of blood clotting time; Combs test false positive. Increase AST and ALT index, alkaline Phosphatase, Bilirubin. Pain at the injection site. Increased urea, serum creatinine; Urine test for abnormal readings.
6. Drug interactions
Some interactions when taking Pythinam:
Ganciclovir: Concomitant use of Pythinam with Ganciclovir increases the risk of generalized seizures. Probenecid: Increases drug toxicity. To avoid unnecessary drug interactions, you should inform your doctor about all medications, supplements, vitamins you are taking to be considered for treatment.
7. Note when using medicine and how to store it
For pregnant and lactating women: There are no adequate studies on the effectiveness of Pythinam when used in pregnant women, so only use when the benefit to the mother outweighs the risk to the fetus. Imipenem passes into breast milk, breast-feeding should be discontinued if the drug is necessary. People who drive and operate machines: Pythinam may cause dizziness, drowsiness, ataxia or convulsions, which will affect the ability to drive and use machines. Pythinam should be used with caution in people with a history of hypersensitivity reactions to beta-lactam antibiotics, history of gastrointestinal disease, central nervous system disease such as epilepsy, brain damage. Use caution when using Pythinam for the elderly and children under 3 months of age. Dosage should be reduced in patients with renal impairment and the elderly. How to store Pythinam:
Store Pythinam in a cool, dry place, avoiding direct light on the medicine. Keep Pythinam out of the reach of children. Above are the notes on the uses and doses of Pythinam. To ensure the safety of health and maximize the effectiveness of treatment, patients need to take the medicine according to the doctor's instructions.
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