This is an automatically translated article.
Pyrazinamide drug is currently known quite popularly with the main effect of treating bacterial infections of pulmonary tuberculosis. The drug is widely available in all pharmacies nationwide with the form of Pyrazinamide 500mg and Pyrazinamide 400mg.
1. The concept of the drug Pyrazinamide
Pyrazinamide 500mg is indicated in the treatment of pulmonary tuberculosis and the symptoms of extrapulmonary tuberculosis. Pyrazinamide 500mg is a product of Mekophar Chemistry - Pharmaceuticals containing the main ingredient is Pyrazinamide 500mg.
Pyrazinamide 500mg is prepared in the form of tablets, packed in 2 specifications: box of 1 bottle x 250 tablets and box of 10 blisters x 10 tablets.
2. Indications and uses of Pyrazinamide 500mg
Pyrazinamide 500mg is prescribed by doctors and medical professionals in the following cases:
Treatment in newly diagnosed tuberculosis. Re-treatment of pulmonary tuberculosis and the state of extrapulmonary tuberculosis (usually indicated at the onset of these forms). Pyrazinamide 500mMg is often used in combination with some other anti-TB drugs (Isoniazid, Rifampicin...) to enhance the effectiveness of treatment. Ingredients Pyrazinamide is an antibiotic, acting on the mechanism of preventing the growth of bacteria, so it only treats bacterial infections. Therefore, the drug is not effective in treating viral infections (flu, cold). However, there are a number of other effects of the drug that are not listed on the approved drug leaflet, and the doctor can prescribe the drug to the patient. Therefore, patients only use Pyrazinamide 500mg to treat some other diseases when prescribed by a doctor.
3. Contraindications to using the drug Pyrazinamide
Do not use Pyrazinamide 500mg in the following cases:
Patients with hypersensitivity to Pyrazinamide or to any of the excipients of the drug. Patients with impaired liver function. The patient is suffering from Porphyrin metabolism disorder. Patient is in acute gout.
4. Usage and dosage of the drug Pyrazinamide 500Mg
4.1. How to take Pyrazinamide 500mg is taken orally. Pyrazinamide 500mg when taken orally does not depend on meals, so it can be taken with or without meals. However, it is recommended that patients take the medicine at a fixed time of day. Pyrazinamide 500mg should be used in combination with other anti-tuberculosis drugs to achieve high effectiveness. The patient should take the medicine as prescribed and directed by the doctor. 4.2. Dosage The usual dosage for adults and children in each stage of treatment is as follows:
Daily therapeutic dose: Patients take a dose of 20-30mg Pyrazinamide / kg body weight / day. Interval treatment dose (3 days/week): Patients take a dose of 30-40mg Pyrazinamide/kg body weight/day. Interval therapy (2 days/week): the patient takes a dose of 40-50mg Pyrazinamide/kg body weight/day. To ensure the safety and effectiveness of the treatment, patients need to strictly follow the dosage prescribed by the doctor.
5. What should I do when I miss a dose or overdose of Pyrazinamide 500mg?
When forgetting a dose of Pyrazinamide 500mg, the patient should take it as soon as he remembers. If it is almost time for the next dose, the patient should skip the missed dose and take the dose at the pre-set schedule. Do not arbitrarily make up the dose the next day, because it will cause unwanted side effects.
When an overdose of Pyrazinamide 500mg, according to clinical research, the results of liver index tests such as SGOT, SGPT have increased results. The increase of these indicators returned to normal when the patient stopped taking the drug. Therefore, when accidentally using an overdose of Pyrazinamide 500mg, the patient should stop taking the drug immediately and notify the doctor. In case of an emergency, take the patient to the nearest medical facility, and bring all prescriptions and medications the patient has been using for the doctor to diagnose and provide timely treatment. .
6. What are the side effects when using Pyrazinamide 500mmg?
When using Pyrazinamide 500mg, patients may experience the following undesirable effects (ADRs):
Common (ADR > 1/100)
The drug may affect liver function causing hepatitis. Increases metabolism: The amount of uric acid in the blood increases, causing acute gout attacks. Effects on the musculoskeletal system: Pain, aches and pains in large and small joints. Uncommon (1/1000 < ADR < 1/100)
In more severe conditions patients may develop arthritis. Rare (1/10,000 < ADR < 1/1000)
Digestive system disorder causing manifestations such as: Nausea, vomiting, loss of appetite and loss of appetite. Disruption of porphyrin metabolism. Affects kidney function causing difficulty urinating, painful urination. Skin effects: skin irritation, photosensitivity, rash or pruritus. When patients using Pyrazinamide 500mg see the above side effects, they should stop taking the drug and immediately notify the doctor or go to the nearest medical facility for the earliest remedy and treatment.
7. Precautions when using Pyrazinamide 500mmg
Before using Pyrazinamide 500mg, patients should carefully read the instructions for use listed in the medicine box and the doctor's prescription or refer to the notes below.
It is necessary to combine treatment with Pyrazinamide 500mg with other effective drugs to avoid drug-resistant mutations of bacilli in the treatment of tuberculosis, especially in the initial stage of TB treatment. Pyrazinamide 500mg should be used with caution in patients with a history of: diabetes, kidney failure, arthritis, acute gout. There are no specific reports on the safety of the drug for pregnant and lactating women, so pyrazinamide should only be used in this group of people when absolutely necessary and under the direction of a doctor. Store the medicine in a cool, dry place, away from direct sunlight and at a suitable temperature not exceeding 30°C.
8. Drug interactions of drugs Pyrazinamide 500mg
Pyrazinamide 500mg drug may interact with some of the following drugs:
Pyrazinamide increases the amount of uric acid in the blood and reduces the effect of gout medications such as: Sulfinpyrazone, Allopurinol, Probenecid, C olchicine. Therefore, patients should consult their doctor to adjust the dose of these drugs when taking with Pyrazinamide 500mg. Cyclosporine: When pyrazinamide is used concurrently with this drug, the concentration of Cyclosporine will be reduced, so it is necessary to monitor the concentration of Cyclosporine in the serum. With the useful information provided above, hopefully, it will help readers have more useful knowledge about the Pyrazinamide 500mg drug line. Patients should always strictly follow the medication prescribed by the doctor or pharmacist, absolutely do not change the dose and use method to avoid unwanted effects.
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