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Pularon 5 has the main ingredient is prednisolone 5mg, is made in tablet form. The drug has anti-inflammatory and immunosuppressive effects, used in many pathologies such as rheumatoid arthritis, lupus, temporal arteritis, bronchial asthma, ulcerative colitis, hemolytic anemia, leukopenia particles, anaphylactic shock.
1. What is Pularon?
What is Pularon? Pularon 5 comes in tablet form, the main ingredient is Prednisolone 5mg. The drug has anti-inflammatory and immunosuppressive effects in the pathologies of rheumatoid arthritis, systemic lupus erythematosus, temporal arteritis and inflammation around the nodal artery, sarcoidosis, bronchial asthma, ulcerative colitis, hemolytic anemia, agranulocytosis, and severe allergies including anaphylaxis. In addition, it is also used in the treatment of advanced leukemia, lymphoma, breast cancer, and advanced prostate cancer.
2. Dosage - How to take Pularon
Dosage of Pularon 5 varies depending on the disease condition and the patient's ability to respond. For adults, the starting dose can range from 5-60mg/day depending on the type of disease to be treated and is usually divided into 2-4 times/day. For children, the dose ranges from 0.14-2mg/kg/day, divided into 4 times/day.
How to use: Take orally, should be taken with or after meals. Do not drink with milk, tea, coffee or carbonated, alcoholic beverages.
3. Contraindications to the drug Pularon 5
Pularon 5 is contraindicated in the following subjects:
Hypersensitivity to prednisolone or other components of the drug Severe infections, except for diseases that can be used with specific antibacterial therapy such as septic shock and meningitis. Herpes simplex infection of the eye, which can cause eye perforation Taking a live or attenuated virus vaccine Person with chickenpox
4. Drug interactions
Prednisolone is an inducer of the cytochrome P450 enzyme, and a substrate of the P450 CYP 3A enzyme. This drug therefore affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconazole, rifampicin Phenytoin, phenobarbital, rifampicin and hypokalemic diuretics may reduce the potency of Prednisolone Prednisolone may cause hyperglycemia. blood pressure, thus requiring higher insulin doses Avoid concomitant use of Prednisolone with non-steroidal anti-inflammatory drugs, as gastric ulceration may occur
5. Side effects of the drug Pularon 5
The high risk of side effects is common in people taking high doses and long-term. Pularon 5 may cause some of the following side effects:
Common: Insomnia, nervous excitability, increased appetite, indigestion, hirsutism, diabetes, joint pain, cataracts, glaucoma , epistaxis. Uncommon: Dizziness, convulsions, psychosis, pseudotumor, headache, mood swings, delirium, hallucinations, euphoria, edema, hypertension, acne, skin atrophy, bruising, hyperpigmentation, Cushing's syndrome, pituitary-adrenal axis suppression, growth retardation, glucose intolerance, hypokalemia, alkalosis, amenorrhea, sodium and water retention, hyperglycemia, peptic ulcer - duodenum, nausea, vomiting, abdominal distention, esophagitis, pancreatitis, muscle weakness, osteoporosis, fracture.
6. Limit the risk of Pularon 5 . side effects
In order to limit the risk of side effects, you need to do the following:
In acute indications, except for leukemia and anaphylaxis, only the lowest dose of Pularon 5 should be used in the shortest time. Pularon 5 has the potential to inhibit the hypothalamic-pituitary-adrenal axis with long-term use. Therefore, when wanting to stop the drug, it must be taken gradually, not abruptly, usually every 3 to 7 days, reduce 2.5 to 5 mg, until the physiological dose of prednisolone is approximately 5 mg. If the disease worsens with drug reduction, the dose of prednisolone should be increased and then the dose reduced more slowly. Patients should take a single dose a day instead of divided doses due to less side effects, less adrenal suppression. In alternate day therapy, the dose is divided into a single dose/day, twice a day, in the morning. During treatment should regularly assess and monitor parameters of osteoporosis, hematopoiesis, glucose tolerance, eye and blood pressure Should be combined with antihistamines or proton pump inhibitors when used in high doses Systemic corticosteroids for the prevention of peptic ulcers. Add calcitonin, calcitriol and calcium supplements to prevent osteoporosis in all patients on long-term glucocorticoid therapy. Persons potentially immunosuppressed by glucocorticoids should be warned about the potential for infection
7. Be careful when using Pularon 5
Some notes when using Pularon 5 include:
Pularon 5 should be used with caution for people with osteoporosis, new anastomosis (intestines, blood vessels), mental disorders, stomach ulcers, duodenal ulcers , diabetes, hypertension, heart failure, growing children, the elderly. Always use the lowest dose for the shortest possible time to limit the risk of side effects. Acute adrenal insufficiency may occur with abrupt discontinuation after prolonged treatment with pularon 5 or in the presence of stress. Taking high doses can affect the effectiveness of the vaccine. In summary, Pularon 5 has the main ingredient prednisolone 5mg, which is made in tablet form. The drug has anti-inflammatory and immunosuppressive effects, used in many pathologies such as rheumatoid arthritis, lupus, temporal arteritis, bronchial asthma, ulcerative colitis, hemolytic anemia, leukopenia particles, anaphylactic shock.
To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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