This is an automatically translated article.
Pregobin is a drug belonging to the group of psychotropic drugs with the main ingredient being Pregabalin 75mg. The drug is indicated for the treatment of certain neurological diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
1. What is Pregobin?
Pregobin is a drug belonging to the group of psychotropic drugs with the main ingredient being Pregabalin 75mg and excipients just enough for 1 tablet. The drug is manufactured by Laboratorios Recalcine S.A. Chile and is prepared in the form of film-coated tablets with a box of 3 blisters x 10 tablets. Pregobin is used as an adjunct to the treatment of partial seizures, the treatment of neuralgia and the relief of symptoms of generalized anxiety disorder in adults.
2. Indications to use Pregobin 75mg
2.1. Uses of Pregabalin Active ingredient Pregabalin in the drug has a mechanism of action that is analyzed as follows:
Pregabalin strongly binds to the alpha 2-delta subunit on voltage-carrying calcium channels in the brain. Pregabalin, an antiepileptic and analgesic agent, is associated with binding to the alpha 2-delta subunit. The inhibitory effect of neurotransmitter release by pregabalin can disrupt alpha 2-delta channel transport, reducing calcium influx. Pregobin 75mg has a similar structure to Gamma-Aminobutyric Acid. However, the drug does not act directly on Benzodiazepine, GABAα or GABAβ receptors. Cyclooxygenase enzyme activity remains the same, the drug does not act on opiate receptors and does not block Na+ channels. In addition, Pregabalin also has no effect on serotonin and dopamine receptors. Therefore, Pregabalin has the main effect of treating epilepsy, convulsions and treating nerve pain symptoms.
2.2. Pregobin drug indications Pregobin 75mg drug is used in the following cases:
Support and treatment of partial seizures in adults, generalized epilepsy. Treatment of symptoms of generalized anxiety disorder in adults. Treatment of central or peripheral neuralgia in adults.
3. Dosage and how to use Pregobin 75mg
3.1. How to take Pregabalin is in the form of tablets and is taken orally. Patients should combine drinking with 1 glass of water and swallow whole. Can be taken before or after eating about 30 - 1 hour.
Patients do not arbitrarily change other ways of taking or stop taking the drug completely without a prescription from the doctor.
3.2. Dosage Below is the recommended dose, patients can refer to:
Nerve pain:
Initial dose is 75mg / time (total dose 150mg / day) and divided into 2 times / day. The maximum dose can then be increased to 300 mg/day for 3-7 days and to 600 mg/day after the next 1 week. Treatment of epilepsy:
Initial dose is 75mg/time (total dose 150mg/day) and divided into 2-3 oral doses. Thereafter, the maximum dose may be increased to 300 mg/day for 3-7 days depending on tolerability and response. The dose may be increased to 600 mg/day after the next 7 days. Treatment of anxiety disorders:
The starting dose is 150mg/day and divided into 2-3 oral doses. After 7 days, the dose can be increased to 300mg/day. One week after increasing the dose, the patient can use a dose of 450mg/day. After a period of 1 week the next can be increased to a maximum dose of 600mg/day. Dosage in children:
Pregobin 75 mg is not recommended for use in patients under 18 years of age, because there are no precise data on safety and efficacy in this group. Dosage in the elderly (over 65 years old):
Pregabalin dose adjustment for this age group is not required, except in cases of impaired renal function. The long-term use of Pregabalin should be re-evaluated when the patient's response to the drug is allowed to increase the dose.
4. Contraindications to taking Pregobin 75mg
Pregobin 75mg should not be used in the following cases:
Patients who are sensitive or allergic to Pregabalin or any of its ingredients. Do not take Pregabalin with a nursing woman.
5. Pregobin drug interactions
Below are some possible interactions when combining Pregobin with other drugs.
Concomitant use of Pregabalin with antidiabetic drugs of the Thiazolidinedione group (Pioglitazone, Rosiglitazone, ...) may cause fluid retention and weight gain or heart failure in susceptible patients. Concomitant use of ACE inhibitors such as Benazepril, Captopril, Enalapril,...with Pregabalin may lead to the risk of angioedema. Concomitant use with 1,4-benzodiazepine psychotropic drugs may cause a risk of CNS depression and respiratory depression. Especially in debilitated people and the elderly. Pregobin medicine used together with alcohol during treatment can increase unwanted effects on the nervous system such as dizziness, difficulty concentrating, drowsiness, ... Pregabalin absorption rate may be slightly decreased when used with gabapentin. When Lorazepam and ethanol are used with Pregabalin may affect Pregabalin may increase the pregabalin effect slightly when used together with the central analgesic effect of ethanol and lorazepam. Patients need to immediately inform the doctor, pharmacist of the drugs that you are using so that they can prescribe a reasonable dose and avoid possible adverse interactions.
6. What side effects does Pregobin 75mg cause?
When using Pregobin 75mg for treatment, you may experience some unwanted side effects as follows:
Dizziness Drowsiness or insomnia Increased appetite Excited mood Irritability Decreased sex drive Disorientation Memory impairment Concentration disorder Balance disorder Headache Ataxia Blurred or double vision Vestibular disorders Vomiting Dry mouth Constipation Erectile dysfunction Abnormal gait Fatigue External edema vi/edema Weight gain Smoking withdrawal syndrome Immediately notify the doctor or pharmacist when the patient stops taking and experiences any unwanted effects while using Pregabalin for reasonable advice.
7. Precautions when using Pregobin 75mg for treatment
Pregabalin should be used with caution in patients with kidney failure, diabetes, and cardiovascular disease. In children under 17 years of age, safety and efficacy have not been established. Patients should stop taking Pregabalin as soon as symptoms of angioedema appear. Pregobin 75mg should be used with caution during pregnancy as no harm to the fetus has been reported. Unless it is absolutely necessary, it should be used and must be prescribed by a doctor or pharmacist. Pregabalin can cause visual disturbances when taking the drug. Patients who are using high doses and long-term, absolutely do not stop the drug suddenly, because it can cause excessive side effects. The recommended dose should be gradually reduced over at least 1 week. Pregabalin has the side effects of dizziness, nausea, and decreased attention. Therefore, patients should not take the drug while driving, operating machinery or doing jobs that require high concentration. There are no data on whether or not Pregobin is excreted in human milk, so it is not recommended for use in nursing women. However, there have been reports of pregabalin in breast milk and the risk is unknown. Therefore, patients need to carefully weigh the benefits and risks before using them. If you must take Pregabalin, you should stop breastfeeding. For young children: neither efficacy nor safety in children under 18 years of age. Therefore, Pregabalin should not be used in this population. For the elderly: Pregabalin dosage needs to be adjusted in the elderly because renal function often declines. Patients need to use caution and follow the instructions of the doctor, pharmacist. The above article is all information about the drug Pregobin 75mg, however, it cannot replace the leaflet and instructions from the medical person in charge. Patients should consider carefully before taking the drug to limit unwanted side effects.
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