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Piromax is manufactured and registered by TV.Pharm Pharmaceutical Joint Stock Company, belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, drugs to treat Gout and joint diseases.
1. What is Piromax?
Piromax medicine has the main ingredient containing the active ingredient Piroxicam 10mg, made in the form of hard capsules, packed in boxes of 10 blisters, 1 blister of 10 tablets.
2. Pharmacodynamics and pharmacokinetics of Piromax
2.1. Pharmacodynamics Active ingredient Piroxicam is a non-steroidal anti-inflammatory drug, belonging to the oxicam group. Its main effects are antipyretic, analgesic, anti-inflammatory. The mechanism of action of the drug has not been clarified, but based on the above effects, it can be seen that the general mechanism is due to inhibition of synthetase, prostaglandins. Thus preventing the formation of thromboxane, prostaglandins and other products of the enzyme cyclooxygenase. Anti-inflammatory effects also include inhibition of collagenase and proteoglycanase in cartilage, because Piroxicam can also inhibit neutrophil activation, even in the presence of cyclooxygenase. In addition, Piroxicam also inhibits platelet aggregation.
Mechanism of action Piromax inhibits the synthesis of prostaglandins in the kidneys, causing decreased blood flow to the kidneys.
2.2. Pharmacokinetics Absorption: The active substance Piroxicam is well absorbed from the gastrointestinal tract, 3 to 5 hours after oral administration peak plasma concentrations appear. The rate and extent of drug absorption are not affected by antacids and food. Because of the great difference in absorption between patients and Piroxicam has an enterohepatic cycle, the plasma half-life also varies greatly from 20 to 70 hours. From this, it can be explained why when using the same dose, the effect is different for each patient. Distribution: Piromax is very strongly bound to plasma proteins reaching about 99%. The volume of distribution of the drug is approximately 120 mL/kg. The drug concentrations in the synovial fluid and in the plasma will be approximately equal when the drug is at steady state after 7 to 12 days. Metabolism and Elimination: When levels are less than 5%, the drug will be excreted in the urine unchanged. The major metabolite of the drug is hydroxylation of the pyridine ring, followed by conjugation with glucuronic acid, after which the conjugate is excreted in the urine.
3. Effects of Piromax
3.1. Indications for Piromax Piromax is indicated for use in the following cases:
Used to treat cases of osteoarthritis, rheumatoid arthritis, osteoarthritis, acute musculoskeletal disease, ankylosing spondylitis, Sports injuries, acute gout, bursitis, tendinitis, neuritis, back pain. Treatment of postoperative pain and dysmenorrhea. 3.2. Piromax drug Contraindications Piromax is not indicated for the following cases:
Subjects with hypersensitivity to any of the components of Piromax. The patient has duodenal ulcer, acute gastric ulcer. Patients with a history of asthma, bronchospasm, nasal polyps, urticaria or Quincke's edema caused by aspirin or another NSAID, cirrhosis of the liver, severe heart failure, severe renal failure or who are at high risk of bleeding.
4. Usage and dosage of Piromax
4.1. How to take Piromax medicine is used orally, taken immediately during or after meals.
4.2. Dosage Adults: Once a day, 20mg, the response of the drug increases slowly over several weeks due to the prolonged half-life, so the drug concentration has not reached a stable level. Treatment in acute gout: Treatment within 5 to 7 days, 40mg daily. Children: The drug is not intended for use in children. However, in children over 6 years old and with hip arthritis, it can be used at a dose of 5mg / day for children under 15kg, children weighing 16 to 25kg use a dose of 10mg / day, weighing from 26 to 45kg Use dose 15mg/day and children weighing over 46kg use 20mg daily dose.
5. Piromax drug interactions
Increases the anticoagulant effect of Coumarins when co-administered with Piromax. The concentration of lithium will increase in plasma leading to increased toxicity of lithium when co-administered with Piromax, so it is necessary to closely monitor the concentration of lithium in the blood plasma. Co-administration of Piromax with Asprin was not more effective but increased undesirable effects in patients because Aspirin lowers plasma concentrations of Priroxicam.
6. Undesirable effects when using Piromax medicine
Common side effects when patients use Piromax such as: loss of appetite, stomatitis, epigastric pain, constipation, diarrhea, nausea, indigestion, abdominal pain, anemia, eosinophilia, leukopenia, decreased red blood cells and hematocrit, rash, itchy skin, drowsiness, dizziness, dizziness, increased creatinine and blood urea, malaise, headache, edema, tinnitus.
Less common side effects with Piromax: jaundice, abnormal liver function, hepatitis, perforation and ulceration, gastrointestinal bleeding, dry mouth, bruising, petechiae, marrow depression, decreased urination glomerulonephritis, sweating, Stevens-Johnson syndrome, erythema, insomnia, irritability, restlessness, depression, interstitial nephritis, hematuria, nephrotic syndrome, proteinuria, flu-like symptoms , fever, blurred vision, eye swelling, eye irritation, congestive heart failure, increased blood pressure.
Other side effects are very rare such as: pancreatitis, hair loss, nail loss, hallucinations, restlessness, mood changes, restlessness, confusion paresthesia, urinary retention, weakness, hearing loss transient force, hemolytic anemia.
When using Piromax, patients experiencing any unwanted effects should notify the doctor, to be monitored and given timely and effective treatment directions.
7. Pay attention to using Piromax medicine
When appointing Piromax drug treatment, caution should be exercised in the following subjects: the elderly, patients using diuretics, cardiovascular disease, bleeding disorders, history of liver failure, renal failure, stomach ulcers thick-duodenum.
In addition, it should be noted, do not use on pregnant women and lactating mothers.
Piromax is manufactured and registered by TV.Pharm Pharmaceutical Joint Stock Company, belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, drugs to treat Gout and joint diseases. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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