This is an automatically translated article.
Pemnat 500 medicine contains the main ingredient is Pemetrexed disodium, the dosage form of lyophilized powder for intravenous infusion. Knowing the necessary information of Pemnat 500 drug about ingredients, uses, doses and side effects will help improve treatment results for patients.
1. What is Pemnat 500?
Pemnat 500 belongs to the group of anti-cancer drugs and acts on the immune system. The drug is indicated for:
In combination with Cisplatin in the initial treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). In combination with pembrolizumab (Keytruda) and platinum chemotherapy for the initial treatment of patients with metastatic/non-small cell lung cancer, without EGFR or ALK genomic aberrations. Maintenance monotherapy for patients with metastatic or non-small cell lung cancer (NSCLC) whose disease has not progressed after 4 cycles of platinum-based first-line chemotherapy. Monotherapy for the treatment of patients with recurrent metastatic non-small cell lung cancer (NSCLC) following prior chemotherapy. In combination with cisplatin in the initial treatment of patients with malignant pleural mesothelioma (MPM).
2. Contraindications of Pemnat 500
Pemnat 500 is contraindicated in the following cases:
Patients with hypersensitivity to any ingredient in the drug Pemnat 500. Women who are pregnant and breast-feeding. Just got the yellow fever vaccine.
3. Pemnat 500 . drug interactions
Pemnat 500 may have an interaction reaction if used concurrently with:
Aminoglycoside drugs; Loop diuretics ; Platinum compounds; Cyclosporin drugs; Drug Probenecid ; Penicillin drugs; NSAIDs (high dose); Aspirin medicine; Oral anticoagulants; Live vaccines reduce toxicity. To avoid interactions, before being prescribed Pemnat 500, the patient should inform the doctor about the drugs they are using, including functional foods. The doctor will base on that to prescribe the appropriate Pemnat 500.
Although dangerous drug or food-induced drug interactions have not been detected with Pemnat 500, it cannot be subjective. Patients need to actively exchange all health information as well as drug use status at the time of prescription with the doctor. Information about current drug products and medical records can be the basis for doctors to assess the risk of drug interactions after a patient uses them.
4. Side effects of Pemnat 500
During the use of Pemnat 500, patients may experience undesirable effects such as:
Decrease in neutrophils / granulocytes; Leukopenia; Reduced Hb; Thrombocytopenia; Conjunctivitis; Diarrhea, vomiting; Inflammation of the mouth/throat; Nausea; Anorexia; Constipation ; Undigested; Tired; Dehydration; Sensory neuropathy;bght Taste disorder; Increased creatinine; Reduce ClCr; Board; Hair loss. The side effects of Pemnat 500 are still being analyzed and monitored in patients with the same experimental results. It is not possible to confirm that the above are all effects of Pemnat 500. However, based on that, patients can avoid dangerous effects due to side effects.
In a few rare cases when using Pemnat 500 medicine, complications or interactions may not manifest, often with serious consequences. To protect their own health to avoid serious effects when taking Pemnat 500, patients should tell their doctor about any unusual signs. At the same time, you should carry out regular health check-ups according to the instructions of your doctor.
5. Pay attention to precautions when using Pemnat 500
Care should be taken when using Pemnat 500 in the following subjects:
Patients with dehydration; People with hypertension and diabetes; People with pre-existing cardiovascular risk factors; Clinically significant third compartment fluid; Adult males (may cause genetic damage); Undergoing radiation treatment; Mild to moderate renal failure; Pregnant women; Driver/machine operator.
6. Instructions for using Pemnat 500
Dosage of Pemnat 500 in combination with cisplatin:
The first day of every 21-day cycle: Intravenous infusion over 10 minutes 500 mg/m2 ALIMTA. About 30 minutes later, give a 2-hour infusion of 75mg/m2 Cisplatin. Antiemetic and rehydration before and/or after Cisplatin infusion. Dosage of Pemnat 500 for use alone:
Non-small cell lung cancer with chemotherapy: First day of every 21-day cycle: Intravenous infusion over 10 minutes 500 mg/m2. Adjust the dose for the next cycle based on toxicity, in addition to hematologic and neurotoxicity. Note:
Patients need to take 1 Corticosteroid (equivalent to Dexamethasone) 4mg x 2 times/day the day before, the day of infusion and the day after the infusion of Pemnat 500. At the same time, it is necessary to add at least 5 doses of Acid. folic acid (or a multivitamin containing folic acid (350-1000 mcg)) for 7 days before the first dose of Pemnat 500. Continue taking during treatment and for 21 days after the last dose of Pemnat 500. Intramuscular vitamin B12 (1000 mcg) in the week before the first dose of Pemnat 500 and every 3 cycles thereafter (possibly the same day as Pemnat 500). The above dosage of Pemnat 500 is for reference only. The specific dosage of Pemnat 500 depends on the condition and the progression of the disease. To get the right dose of Pemnat 500, patients should consult their doctor or healthcare professional. How to deal with missed dose, overdose of Pemnat 500:
In case of forgetting dose of Pemnat 500, it is advisable to supplement as soon as possible. However, if it is almost time for the next dose, skip the missed dose of Pemnat 500 and use a new dose. When using Pemnat 500 drug overdose, the patient should stop the drug immediately and go to the nearest medical facility for timely treatment. Above is all information about Pemnat 500 medicine, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Pemnat 500 to treat at home because there may be unwanted side effects.
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