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Pecrandil 10 is used to treat and support the treatment of angina pectoris, available in most pharmacies nationwide. Let's find out more details about the use and use of Pecrandil 10 through the article below.
1. What is Pecrandil 10?
Pecrandil 10 belongs to the group of cardiovascular drugs to help prevent and treat angina pectoris. The drug has the main active ingredient Nicorandil 10 mg and other excipients such as: Microcrystalline cellulose, Sodium starch glycolate, Lactose, Crospovidone, talcum powder, Magnesium stearate, Colloidal silicon dioxide. The drug is prepared in the form of tablets packed in boxes of 6 blisters x 10 tablets.
2. Indications for taking Pecrandil 10
Pecrandil 10 is used to treat long-term stable angina. Reduce the risk or control of acute coronary disease in high-risk patients.
3. Dosage and how to use Pecrandil 10
Pecrandil 10 is used for oral administration.
Dosage:
Adults: 10mg Nicorandil x 2 times/day, if prone to headache use 5mg Nicorandil x 2 times/day, increase dose according to response, normally 10-20mg Nicorandil x 2 times/day, evening maximum 40mg Nicorandil x 2 times/day. No dose adjustment of Nicorandil is required in the elderly. Nicorandil is not recommended for use in children.
4. Contraindications to the use of Pecrandil 10
Pecrandil 10 should not be used in the following patients:
Cardiogenic shock Left ventricular heart failure with low filling pressure Hypotension. Decreased circulatory volume Acute pulmonary edema Patients with K(+) blood, eye mucosal ulcers, gastrointestinal ulcers. Patients with reduced G6PD Patients with hypersensitivity to Nicorandil or any ingredient in the drug.
5. Pecrandil 10 . drug interactions
Pecrandil 10 drug used concurrently with some other drugs can cause interactions such as:
Co-administration of Nicorandil with the stimulant Guanylate (Riociguat) can lower blood pressure. Concomitant use of Nicorandil with 5-Phosphodiesterase inhibitors (Tadalafil, Sildenafil, Vardenafil) can lead to a serious drop in blood pressure. Patients with low blood pressure when taking Nicorandil in therapeutic doses can also cause a drop in blood pressure. Nicorandil used at the same time with antihypertensive drugs or substances with antihypertensive effects such as vasodilators, tricyclic antidepressants, alcohol may increase the antihypertensive effect. Caution should be exercised when using Nicorandil with Dapoxetine because it can cause orthostatic hypotension. When Nicorandil is co-administered with corticosteroids, gastrointestinal perforation has been reported. Concomitant use with NSAIDs (including Aspirin) at doses to prevent cardiovascular disease and coagulation increases the risk of perforation, ulceration, and gastrointestinal bleeding. Nicorandil should be co-administered with caution with other hyperkalemic agents.
6. Side effects when taking Pecrandil 10
During the use of Pecrandil 10 treatment, patients may experience some unwanted side effects such as:
Headache (usually mild and encountered at the beginning of treatment) Vasodilation under the skin. Vomiting, dizziness, fatigue, drowsiness, muscle weakness. Myalgia, skin erythema, mouth ulcers (may appear late and often appear with high doses) Angioedema, decrease in blood pressure, increase in heart rate, liver dysfunction (common with high doses) When Patients experiencing dangerous side effects such as persistent anal ulcers, persistent headache, decreased blood pressure and tachycardia should discontinue the drug or reduce the dose. In addition, please inform your doctor for the best treatment.
7. Precautions when using Pecrandil 10
Pecrandil 10 should be used with caution in patients with:
Heart attack, low blood pressure, heart valve disease with hemodynamic disturbances. Because the drug has a risk of lowering blood pressure or anemia. Have atrioventricular conduction disorder. Patients with recent traumatic brain injury or cerebral hemorrhage. Have severe liver disease. Are being treated with other nitrate derivatives because of possible increased toxicity when used. Do not use Nicorandil in patients with glucose intolerance, lactase deficiency, glucose - galactose malabsorption. Do not drive, operate machinery, or do jobs that require high concentration while taking Nicorandil. Nicorandil should be used with caution in pregnant women and nursing mothers. Because there are not enough data on safety and effectiveness when using. Please consider carefully and consult your doctor, pharmacist before taking Pecrandil 10 during this period.
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