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Pariben 20mg drug contains the main ingredient Rabeprazole 20mg and other excipients in sufficient quantity. Pariben 20mg gastrointestinal drug is effective in the short-term treatment of erosive esophagitis, pathological increase in acid secretion.
1. What is Pariben?
1.1. Ingredients of the drug Pariben 20mg Ingredients: Each enteric-coated tablet of Pariben 20mg contains the main ingredient Rabeprazole sodium with a concentration of 20mg and other excipients in sufficient quantities.
Pariben 20mg is prepared in the form of enteric coated tablets, suitable for direct oral use.
1.2 The effect of the drug Pariben 20mg Main active ingredient Rabeprazole sodium is a new proton pump inhibitor, also a Benzimidazole derivative. Rabeprazole is converted to the active form of sulphenamide through protonation, which then reacts with the cysteines available on the proton pump. Through combining with the enzyme H+/K+-ATPase present on the parietal cells of the stomach, the active ingredient Rabeprazole blocks the final step of gastric acid production. The inhibitory effect on acid secretion of the active ingredient Rabeprazole includes both basal and stimulated acid secretion, regardless of the stimulus. This effect also depends on the dose of active ingredient Rabeprazole taken into the body. In vitro and animal studies have demonstrated that Rabeprazole is a more potent inhibitor of H+/K+-ATPase and acid secretion than Omeprazole. Rabeprazole also gives the above effect faster than Omeprazole, Lansoprazole or Pantoprazole. This is due to the faster activation of the active substance Rabeprazole in the canals of parietal cells. As with other proton pump inhibitors, Rabeprazole exhibited antibacterial activity against Helicobacter pylori in in vitro studies. Rabeprazole's activity against HP is stronger than that of Lansoprazole and Omeprazole. The main mechanism in the HP-killing effect of Rabeprazole is the inhibition of bacterial urease activity. Furthermore, the Thioether derivative of Rabeprazole inhibited the growth and motility of H. pylori resistant to clarithromycin more strongly than PPIs or other antibacterial agents.
2. What are the uses of Pariben?
The drug Pariben 20mg is used in the treatment of specific diseases as follows:
Used for cases of active gastric - duodenal ulcer, ulcerative stomatitis - jejunal junction,... Symptomatic treatment or maintenance for gastroesophageal reflux disease . Indications for the treatment of Zollinger-Ellison syndrome. Combination in the treatment regimen of H.pylori infection for subjects with gastrointestinal ulcers.
3. Usage and dosage of the drug Pariben
3.1. Dosage of Pariben 20mg Dosage for treatment of gastroesophageal reflux - oesophagitis is a dose of 1 tablet of Pariben 20mg x 1 time / day, lasting from 4 to 8 weeks. If still not cured, use 1 more course of Pariben 20mg for another 8 weeks. Dosage for treatment of Zollinger-Ellison syndrome begins with 3 tablets of Pariben 20 mg x 1 time / day, then adjust the dose depending on the clinical response of the individual. Dosage for treatment of gastrointestinal ulcers, take 1 tablet of Pariben 20mg x 1 time/day, a course of treatment is 4 weeks. 3.2. How to use Pariben 20mg effectively The enteric coated tablet dosage form of Pariben 20mg helps to protect the drug from being destroyed by gastric juice, as well as to increase its bioavailability. To protect this coating, the user swallows the Pariben 20mg tablet whole and does not chew, bite, break or otherwise destroy the tablet. Food or time of ingestion does not affect the absorption of Pariben 20mg. However, it is best for patients to take this drug at the same time of day to ensure adherence. The optimal time for taking Pariben 20mg is in the morning, 30 to 60 minutes before eating. 3.3. How to deal with missed dose, overdose of Pariben 20mg In case of missed dose: You should take the initiative to make up the dose if you forget as soon as you remember. However, you should skip the missed dose if it is almost time for your next dose and use your next scheduled dose. In case of overdose: There is currently no experience of overdosage with the active ingredient Rabeprazole. If the user accidentally overdoses and shows adverse side effects, the user should immediately take the user to the nearest medical facility. Currently, there is no specific antidote, symptomatic treatment combined with supportive treatment.
4. Undesirable effects of the drug Pariben
During the use of Pariben 20mg drug, some side effects may be encountered for users, specifically as follows:
For the whole body: Fever, allergies, body weakness, increased photosensitivity light, uncomfortable, chest pain below the sternum. For the digestive system: Nausea, vomiting, dry mouth, flatulence, abdominal pain, indigestion,... For the endocrine system: Hyperthyroidism or hypothyroidism. For the cardiovascular system: Hypertension, syncope, angina, palpitations, arrhythmia... For the blood and lymphatic system: Lymph node disease, anemia, bruising appear. For the respiratory system: Hiccups, shortness of breath, asthma, laryngitis, hyperventilation, nosebleeds. For the nervous system: Dizziness, nervousness, drowsiness, insomnia, anxiety disorders, dizziness, convulsions... For urology - genitourinary: Difficulty urinating, polyuria, cystitis, ejaculation uterine bleeding, dysuria, dysuria. Affect values in some tests such as abnormal platelets, hyperglycemia, increased blood cholesterol... If during the use of Pariben, you have any adverse effects, you need to proactively notify the treating doctor or qualified pharmacist for appropriate support measures.
5. Interactions of drugs Pariben
Pariben 20mg drug causes strong and prolonged inhibition of gastric acid production. It is therefore entirely possible that there is a risk of interaction of Pariben 20mg with compounds whose absorbance is dependent on pH. Concomitant use of Pariben 20mg with drugs such as Ketoconazole, Itraconazole, or Atazanavir can significantly reduce plasma concentrations of these drugs. Using Pariben 20mg with Methotrexate may increase blood levels and side effects of the active ingredient Methotrexate. Therefore, the treating physician considers that it may be necessary to implement safer alternatives or adjust the dose if Pariben 20 mg is co-administered with Methotrexate. Clopidogrel also has the potential to reduce the effect of stroke prevention if combined with Pariben 20mg.
6. Some notes when using Pariben
6.1. Contraindications of the drug Pariben 20mg Do not use Pariben 20mg for people with hypersensitivity or sensitivity to any of the ingredients of the drug. Pariben 20mg should not be used in children under 12 years old and pregnant or lactating women. 6.2. Notes and cautions when using Pariben 20mg Treatment with Pariben 20mg may inadvertently mask the signs of cancer of the esophagus or stomach. Therefore, it must be determined that the patient does not have a new melanoma to be prescribed Pariben 20mg. The effect of reducing acid secretion of the drug Pariben 20mg causes the normal intestinal bacteria to increase in number. That is why the use of Pariben 20mg as well as other antacids easily leads to the risk of gastrointestinal infections. In rare cases, users may experience hypomagnesium in the blood when taking Pariben 20mg for at least 3 months. The treating doctor can handle it by stopping the use of Pariben 20mg and adding magnesium. 6.3. For pregnant and lactating women Using the drug with pregnant women: Safety has not been established for pregnant women, so its use is contraindicated. Use in nursing mothers: Pariben 20 mg may be excreted in breast milk and may be harmful to a nursing infant. Consider whether to discontinue use or discontinue breast-feeding based on the importance of treatment to the nursing mother. mother's health. 6.4. For drivers and operators of machines Specific adverse reactions such as dizziness, lightheadedness, drowsiness, vomiting, abdominal pain may be experienced when using the drug. You need to pay attention to caution when using Pariben 20mg for these subjects. At the same time, users of this drug should also be warned of the risks.
6.5. How to store Pariben 20mg medicine Store Pariben 20mg at a temperature below 25 degrees Celsius, do not expose the medicine to direct sunlight. Pariben 20mg should be used immediately after separating the tablet from the protective shell. Store medicines out of the reach of children to reduce the risk of children accidentally taking the wrong medicine. Above is all information about the drug Pariben, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Pariben to treat the disease at home, because there may be unwanted side effects to health.
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