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Pannefia-40 has the effect of reducing gastric acid secretion, used in the treatment of peptic ulcers, gastroesophageal reflux syndrome. Here are some things to know about the uses, usage and precautions when taking Pannefia 40.1. Uses of Pannefia 40
Pannefia 40 medicine contains the main ingredient is Pantoprazole Sodium Sesquihydrate equivalent to 40mg Pantoprazole, made in the form of tablets. Pantoprazole is a proton pump inhibitor (PPI) in the stomach.
Pantoprazole, after entering the acid-secreting tubules of gastric parietal cells, will be converted into active sulfenamide. This form irreversibly binds with the enzyme H + / K + - ATPase (called proton pump) present on the surface of gastric mucosal cells, inhibiting this enzyme, preventing acid secretion into the gastric lumen. Therefore, Pantoprazol has a selective and irreversible inhibitory effect on the proton pump, thereby reducing the increase in gastric secretion, promoting the healing of ulcers. The drug did not affect the total amount of gastric juice secreted, but reduced the amount of acid in the gastric juice and did not affect the secretion of pepsin.
In general, the uses of Pannefia-40 are as follows:
Prevents the secretion of Acid into the stomach, thereby helping to increase gastric pH; Reduces the effect of gastric acid on the lining of the stomach and duodenum, which is inflamed or ulcerated. Pannefia 40 is a medicine that lasts more than 24 hours.
2. Indications and contraindications of Pannefia-40
Pannefia-40 is indicated for use in the following subjects:
Stomach ulcer or duodenal ulcer; Moderate and severe gastroesophageal reflux; Zollinger-Ellison syndrome ; In combination with antibiotic therapy in the treatment of peptic ulcers caused by H. Contraindicated to use the drug for the following subjects:
Do not use for people with a history of allergy to pantoprazole or any of its excipients; Not intended for use by persons under 18 years of age.
3. Usage and dosage of Pannefia-40
3.1. How to use Pannefia-40 The drug is prepared in the form of tablets and taken orally with a full glass of water. When taking you need to swallow the tablet whole, do not bite, break or chew because this will break the special dosage form of the drug. When to take Pannefia: The right time to take the medicine helps to better deal with the symptoms of the disease, the drug is indicated to be taken 30 minutes before breakfast. If taken twice, the second dose should be taken before dinner. Because the drug takes time to inhibit the parietal cells secreting gastric acid during meals, it should be taken before meals. You should take the medicine exactly as prescribed by your doctor and use it regularly to ensure effective treatment. If you want to stop treatment, tell your doctor. Do not use this medication for more than 8 weeks as there are currently insufficient data on long-term use. 3.2. Dosage of Pannefia 40 Treatment of gastric ulcer - duodenal ulcer:
Peptic ulcer with the presence of HP bacteria, then combine this drug according to 1 of 3 treatment regimens to kill HP as follows: Pannefia 40 1 tablets, 1000mg Amoxicillin and 500mg Clarithromycin. Use twice a day; Pannefia 40 1 tablet, 500 mg Metronidazol combined with 500 mg Clarithromycin. Use twice a day; Pannefia 40 1 tablet, 1000 mg Amoxicillin and 500 mg Metronidazol. Use twice a day; Peptic ulcer without HP: Use Pannefia 40mg 1 tablet/day. Treatment of gastroesophageal reflux - esophageal:
Use Pannefia 40 1 tablet / time / day for 4 weeks, can be used up to 8 weeks if necessary. If the esophageal ulcer does not heal after 8 weeks of treatment, it can be continued for another 8 weeks as indicated; Maintenance treatment: Take 1 tablet/day; Note: Safety and effectiveness for this use for more than 1 year have not been established. Zollinger - Ellison syndrome:
Initial dose: Pannefia 40 2 tablets / time / day, then adjust depending on the patient's response. The dose can be increased up to 240 mg per day; If the daily dose is above 80 mg, it should be divided into 2 times a day. For special cases (patients with kidney failure and elderly patients, people with severe liver failure):
Maximum dose of 40mg in patients with renal failure, elderly patients. Except for cases of peptic ulcer caused by Helicobacter pylori in the elderly, the usual dose of Pantoprazole is 1 tablet/time, twice daily for 1 week; People with severe liver failure: Take 1 tablet / time and 2 times a day. How to handle missed dose and overdose:
Missed dose: If you do not take the medicine at the indicated time, you should not take up the dose at other times of the day such as after meals. Skip the missed dose and resume normal treatment the next day. Overdose: May occur with symptoms such as tachycardia, vasodilation, confusion, headache, blurred vision, nausea and vomiting, abdominal pain, somnolence. When you have these signs, you should immediately go to the nearest medical facility to be monitored and treated for unusual symptoms. There is no specific antidote, so measures such as gastric lavage, activated charcoal, symptomatic treatment and functional support can be used.
4. Undesirable effects when using Pannefia 40
Some side effects that have been reported with this drug include:
Common side effects: Fatigue, dizziness, headache, urticaria, skin rash, dry mouth, nausea and vomiting, abdominal bloating, abdominal pain, constipation, diarrhea, muscle pain, joint pain; Less common side effects such as: Body weakness, lightheadedness, dizziness, insomnia, itching on the skin and increased liver enzymes; Rarely include: Profuse sweating, peripheral edema, malaise, anaphylaxis; Rash, acne, alopecia, exfoliative dermatitis, angioedema, erythema multiforme; Stomatitis, digestive disorders, hyponatremia, blurred vision, photophobia, insomnia, somnolence, agitation or inhibition, tinnitus, confusion, hallucinations, paresthesias such as numbness or tingling; Eosinophilia, leukopenia, thrombocytopenia; Impotence , male impotence , hematuria , interstitial nephritis ; Hepatitis, jaundice, hepatic encephalopathy in people with liver failure, increased triglycerides. If any unusual symptoms occur, you need to contact your doctor immediately, for help as soon as possible.
5. Notes when using Pannefia 40
Before using you should check the history of allergy to the ingredients in the medicine. Carefully read the instructions for use of the drug; Gastric cancer should be excluded before taking the drug, because the drug may mask the signs of gastric malignancy; Use in pregnancy and lactation: There are no adequate data on the safety and efficacy of Pannefia 40 in pregnant and lactating women. There is also no specific information on whether the drug passes into breast milk. Therefore, the drug should not be used in these cases. When necessary, consult your doctor and carefully weigh the risks to the fetus, infant, nursing child, and benefit to the mother before deciding to use the drug. Drug Interactions: Pannefia 40 may reduce the absorption of drugs with gastric pH dependent bioavailability, such as ketoconazole. Interactions with other drugs may occur when used concurrently. So to be on the safe side, you should inform your doctor about any medications you are taking. When taking the drug, you should combine it with a healthy and scientific diet to limit the disease. It is necessary to choose a nutritious diet, avoid foods that are too spicy and hot. It is necessary to have a scientific working regime, to avoid stress because it will aggravate the condition of digestive ulcers. The medicine should be stored in a cool, dry place, away from direct sunlight. Note that the medicine should be kept out of the reach of children. Absolutely do not use the medicine after the expiry date printed on the package and showing signs of damage. Above is the information about the drug Pannefia 40. If you have any questions related to the drug, please ask the doctor directly to use the drug safely and effectively.
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