Therapeutic uses of Macriate 20 mg

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1. Uses of Macriate

Macriate medicine has the main ingredient Rabeprazole Sodium, the content is 20mg. The drug is available in the form of enteric-coated tablets. Active ingredient Rabeprazole Sodium has the effect of inhibiting gastric acid secretion in normal state as well as when stimulated. Macriate is indicated for the treatment of the following conditions:
Acute gastric and duodenal ulcers Gastroesophageal reflux disease, which may or may not be accompanied by esophagitis. Duodenal ulcer due to HP virus Oral ulcer Zollinger-Ellison syndrome Reflux esophagitis.

2. How to take and dose of Macriate

Macriate is to be taken orally, take 1 tablet whole with water, do not chew or crush the drug. Dosage and duration of treatment depend on each specific condition as follows:
Acute duodenal ulcer: 1 tablet Macriate 20mg/time/day in the morning, if the ulcer has not healed, it needs to be taken for 4 weeks . Acute gastric ulcer (benign): 1 tablet Macriate 20mg / time / day in the morning, taken for 6 weeks and if the ulcer has not completely healed, it should be used for 6 weeks. Gastroesophageal reflux - oesophagitis with scratches or ulcers: 1 tablet of Macriate 20 mg / time / day, taking the drug for 4 - 8 weeks. Treatment of long-term gastro-oesophageal reflux disease: Depending on the patient's response, the recommended daily dose is 10-20mg/time/day. Gastroesophageal reflux - oesophagitis without esophagitis: the first 4 weeks 10mg / time / day, continue to use if needed. In case the symptoms of the disease do not improve after 4 weeks, it is necessary to re-examine. Zollinger - Ellison syndrome: The recommended starting dose is 60mg/time/day and increased to 120mg/day to the maximum. Or it can be used at a dose of 100mg / time / day and the duration of treatment depends on the clinical symptoms. Duodenal - gastric ulcer accompanied by HP virus infection: 1 Macriate tablet 20 mg/time, combined with clarithromycin 500mg/time and amoxicillin 1g/time, orally twice a day in the morning and evening. No dose adjustment is required in patients with hepatic or renal impairment.

3. Macriate side effects

Macriate medicine can cause some unwanted side effects with the following frequency:
Common: Headache, dizziness, insomnia, rhinitis, sore throat, abdominal pain, nausea, diarrhea, bloating gas, constipation, easy infection, back pain, weakness and some other symptoms similar to flu. Uncommon: Dry mouth, dyspepsia, belching, muscle pain, arthralgia, cramps, drowsiness, or restlessness, chest pain, pruritus, rash, fever, chills, urinary tract infection, elevated liver enzymes . Rarely: Macriate drug rarely causes unwanted side effects such as loss of appetite, taste disturbances, tooth inflammation, gastritis, jaundice, itching, hepatitis, hepatic encephalopathy, visual disturbances, depression, interstitial nephritis, sweating, edema, hypertension, weight gain and changes in blood biochemical tests such as leukocytosis, thrombocytopenia, and neutrophils. Very rare: Stevens-Johnson syndrome, epidermal necrolysis, erythema. Frequency not determined: Enlarged breasts in men, peripheral edema, decreased blood sodium concentration.

4. Some notes when using Macriate

People who are sensitive to the ingredient of Macriate drug, which is rabeprazole or benzimidazole derivatives, pregnant women should not use the drug. The groups of subjects that need to be cautious before taking the drug include: patients with malignant tumors, patients with liver failure, kidney failure, people with stomach ulcers, myasthenia gravis, hepatic coma. Pregnant and lactating women need to weigh the benefits and risks before use, because studies on Macriate in this population are incomplete. People with galactose intolerance or impaired absorption of galactose, glucose should not use this medicine. People on prolonged drug therapy (more than 1 year) should be monitored periodically. The drug may interact with ketoconazole or itraconazole and should not be used concomitantly with other proton pump inhibitors. Macriate is used to inhibit gastric acid secretion and is used to treat gastric and duodenal ulcers, gastroesophageal reflux disease with ulcers, duodenal ulcers caused by HP virus, reflux esophagitis , stomatitis, Zollinger-Ellison syndrome. To ensure effective treatment and avoid side effects, patients need to read the instructions carefully before using or using the prescription of a doctor or pharmacist.
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