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Pacegan is a non-steroidal anti-inflammatory drug that belongs to the group of pain relievers, antipyretics and anti-inflammatory drugs. The drug is effective in treating gout and treating bone and joint diseases. Pacegan is indicated for the relief of mild to moderate pain in the symptoms of headache, muscle pain, migraine, sore throat, menstrual pain, toothache, aches and pains due to colds, flu, fever. After vaccination, pain after tooth extraction... In addition, the drug also works to reduce fever.1. What is Pacegan 500mg? The effect of the drug Pacegan 500mg
Pacegan 500mg medicine contains the following ingredients:
Paracetamol 500mg Excipients just enough 1 tablet (Anhydrous sodium hydrocarbonate, Sodium saccharin, Anhydrous citric acid, Kollidon K30,...) Dosage form: Effervescent tablets Content : 500mg Packaging is: Box of 5 blisters x 4 tablets, Box of 10 blisters x 2 tablets, Box of 25 blisters x 4 tablets Refer to the accompanying drug leaflet for the full composition of the drug.
Active ingredient Paracetamol acts directly on cyclooxygenase (COX) in the central nervous system to reduce pain. Because it does not cause systemic COX effects, this active ingredient does not cause gastric irritation and bleeding like non-steroidal anti-inflammatory drugs (NSAIDs). In addition, the active ingredient Paracetamol helps to dilate blood vessels, increase peripheral blood flow and act on the hypothalamus to lower body temperature in people with fever. Paracetamol is metabolised mainly in the liver and is eliminated in the urine.
2. What disease does Pacegan treat?
2.1. Analgesic effect: Paracetamol is used to temporarily relieve pain in the treatment of mild to moderate pain in signs and symptoms of pain such as headache, toothache, menstrual pain, pain after tooth extraction, ... The most effective pain relievers are low-intensity pain relievers that aren't visceral. Paracetamol is an alternative to salicylates for pain relief or fever reduction, applicable to people who are intolerant of salicylates. 2.2. Antipyretic effect Paracetamol is used to reduce fever in people with fever
3. Usage and dosage of Pacegan
To know how to use, dosage and frequency of using Pacegan, you should carefully read the instructions printed on the package or discuss directly with the doctor treating the disease.
3.1. How to use Pacegan You drop the Pacegan tablet into a glass of water. Wait for Pacegan to completely dissolve the medicine and drink it immediately. You can take Pacegan with a meal or take it 30 minutes after eating. Do not swallow the whole Pacegan tablet directly like other common medicines. This can make Pacegan less effective or cause unwanted reactions. Talk to your treating doctor if you intend to mix Pacegan with other drinks such as coffee, milk, fruit juice,... 3.2. Therapeutic dose of Pacegan The therapeutic dose of Pacegan depends on many different factors. Therefore, you should go to the hospital to get a correct diagnosis and prescribe a specific treatment dose.
Information on therapeutic doses of Pacegan only responds to common cases. At the same time, it is not a substitute for the advice and instructions of the treating doctor or medical staff.
Usual treatment dose for children from 7 to 12 years old
Take 1 tablet / time, each dose is spaced from 4 to 6 hours. Maximum therapeutic dose: 4 tablets / day Usual therapeutic dose for adults and children. Children over 12 years old
Take 1-2 tablets / time, each dose is spaced from 4 to 6 hours. Maximum therapeutic dose: 8 tablets / day (If using 8 tablets, it should be divided into 4 doses) 3.2. Overdose Cases Overdosage of Pacegan or Paracetamol only occurs when taking a single toxic dose (over 30 tablets) or taking high doses in a row for many days. Overdose symptoms appear within the first 2 to 3 hours such as nausea, vomiting, abdominal pain. In more severe cases of overdose, may cause methemoglobinemia (with symptoms of cyanosis of the skin and mucous membranes), disturbances of consciousness, impaired liver function causing jaundice if not promptly treated. Overdose management: Immediately report to medical staff for timely intervention, even if overdose symptoms have not appeared. You can use Acetylcysteine or Methionine as an antidote. If treated late (after taking the drug more than 36 hours), it means that when the liver has been damaged, it will be very difficult to recover.
4. Undesirable effects of the drug Pacegan
Common undesirable effects when taking Pacegan drugs are:
Digestive disorders; Allergic reaction ; Rash on the surface of the skin; Decrease in neutrophils; Decreased platelets. In addition, Pacegan can cause serious skin reactions, including:
Steven-Johnson syndrome (SJS): An allergic reaction to the drug in the form of blisters. Symptoms found are blisters appearing around the eyes, ears, mouth, nose, anus, genital organs, ... Besides, people with this syndrome may also have high fever, dysfunction liver and kidney function and signs of pneumonia.
Acute generalized exanthematous pustulosis (AGEP): This is a condition in which small, sterile papules appear on the surface of the erythematous skin. Small pimples mainly appear in the armpits, face and groin, then can develop all over the body. Recognizing symptoms are high fever and blood tests show a spike in neutrophils.
Toxic epidermal necrolysis (TEN) is the most serious drug allergy, which includes:
Various superficial skin lesions (erythema, bullous, measles-like rash,...)
Lesions Injury to the gastrointestinal mucosa (oral mucosal slip, oropharyngeal ulcer, gastric ulcer, stomatitis, ...) Injury to the eye mucosa (keratitis, purulent conjunctivitis, corneal ulcer,... ) Damage to the genitourinary and urinary system. Other accompanying symptoms include high fever, hepatitis, glomerulonephritis and gastrointestinal bleeding. Note: When you see skin reactions, you need to stop taking the drug and immediately go to the nearest hospital for timely treatment.
5. Interactions of Pacegan
The active ingredient Paracetamol in Pacegan may change the mechanism of action or increase or decrease the elimination of other drugs. This condition can make the medicine less effective or cause the body to develop unusual signs and symptoms.To reduce the risk of drug interactions, you need to talk to your doctor if you intend to combine Pacegan with any other drugs.
Absolutely, do not use Pacegan with the following drugs:
Anticoagulant Isoniazid Anticonvulsant
6. Some notes when using Pacegan
6.1. Contraindications of the drug Pacegan Do not use Pacegan for the following subjects:
People who are sensitive to Paracetamol or other ingredients in the drug. The patient has a G6PD deficiency. Liver failure, severe renal failure. 6.2. Notes and precautions of Pacegan You should be careful when using the drug in the following cases:
Chronic anemia. Liver and kidney disease. Alcoholism (caused by Paracetamol and alcohol are both harmful to the liver). Combination with other preparations also containing the active ingredient Paracetamol can cause overdose or drug poisoning. At the first signs of itching, skin rash or any other sign of hypersensitivity reaction, the patient should stop using Pacegan. People who have ever suffered from serious skin reactions caused by Paracetamol should not use Pacegan again and when coming to the doctor, they need to inform the medical staff about this problem. Studies in human or animal subjects have not identified any risk to pregnancy or embryonic development. Human studies have also revealed no risk of Pacegan use for nursing mothers and breastfed infants. Paracetamol crosses the placental barrier and is excreted in breast milk. As with other drugs, if you are pregnant or nursing, you should consult your doctor or specialist pharmacist before using this medicine. Effects of Pacegan on the ability to drive and use machines: No significant effects. Pacegan is a non-steroidal anti-inflammatory, analgesic, and antipyretic drug. The drug is effective in treating gout and treating bone and joint diseases. Pacegan is indicated for the relief of mild to moderate pain in many medical conditions. To ensure the effectiveness of treatment and avoid side effects, patients need to take the medicine exactly as directed by the doctor, professional pharmacist.
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