Uses of Opelovax

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1. What are the uses of Opelovax?

1.1. What is Opelovax? Opelovax drug belongs to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs, with registration number VNB-3886-05 (with content of 400mg), VNB-3885-05 (with content of 200mg), is a product products of OPV Pharmaceutical Co., Ltd.
The drug is prepared in the form of long film-coated tablets, blisters of 5 tablets, boxes of 5 blisters. With the main active ingredient is Acyclovir 200 or 400mg.
Opelovax is recommended for use in both children and adults.
1.2. What is Opelovax used for? Opelovax or Acyclovir (also known as acycloguanosin) is effective against Herpes simplex and Varicella zoster viruses. The effect of acyclovir is strongest on Herpes simplex virus type 1 (abbreviated as HSV-1) and less effective on Herpes simplex virus type 2 (HSV-2), Varicella zoster virus (VZV), weakest effect on Cytomegalovirus (CMV). ) and Epstein Barr.
Opelovax is prescribed for:
Treatment of first and recurrent Herpes simplex virus infections (types 1 and 2) in the skin and mucous membranes. Prophylaxis of recurrent herpes simplex infections of the skin and mucous membranes at least 6 times per year, in the eye (recurrent keratitis 2 times per year) or in ocular surgery. Treatment of Varicella Zoster virus infection. Immunocompromised patients. Contraindications:
Patients who are allergic to the main active ingredient Acyclovir, valacyclovir or any of the excipients of the drug Opelovax People with renal failure or anuria Pregnant and lactating women.

2. Usage of the drug Opelovax

2.1. How to use Opelovax Opelovax drug is used orally, patients can take it before or after meals. Patients take Opelovax tablets whole with filtered or boiled water, do not crush or break them, or mix the drug with any solution or mixture. Using the correct medicine as prescribed by your doctor, not taking more than the prescribed dose can increase side effects or take less, leading to insufficient blood levels of Opelovax to take full advantage. 2.2. Dosage of the drug Opelovax Adults:
Treatment of primary Herpes simplex infections including genital Herpes simplex: The usual oral dose is 200 mg x 5 times, 4 hours apart. Drink it for 5 to 10 days.
If the patient is severely immunocompromised or malabsorption: 400 mg once x 5 times/day for 5 days. Limiting relapses in immunocompetent people (at least 6 relapses per year): 800mg a day divided into 2 or 4 times. Treatment must be discontinued after 6 to 12 months to reassess results. If recurrence is < 6 times per year, treatment should be given only at the right relapse: 200 mg each time x 5 times/day, orally for 5 days. Start taking medication when symptoms develop. HSV prophylaxis in immunocompromised people: 200-400 mg each time, orally 4 times a day.
HSV infection in the eye:
Treatment of keratitis: 400mg/time x 5 times/day, drink it for 10 days. Prophylaxis of recurrence, keratitis (with 3 recurrences a year): 800mg/day x 2 times/day. Clinical reevaluation after 6 to 12 months of treatment. In case of eye surgery: 800mg/day x 2 times. Children:
From 2 years old and up: Dose as adults. Under 2 years: half the adult dose. Patients with kidney failure: The doctor will consider the dose and the number of times to change depending on the extent of kidney damage.
Adjust the oral dose in patients with renal impairment: The oral dose for HIV-infected patients with renal failure is as follows:
Creatinine clearance > 80 ml/min: No dose adjustment Creatinine clearance in the range of 50 - 80 ml/min: 200 to 800 mg, 6 to 8 hours apart Creatinine clearance between 25 - 50ml/min: 200 to 800 mg, 8 to 12 hours apart Creatinine clearance between 10-25ml/min: 200 to 800 mg , 12 to 24 hours apart Creatinine clearance < 10 ml/min: 200 to 400 mg, every 24 hours Treatment of missed doses: To achieve antiviral treatment, try not to forget the drug, If you forget your medicine, take it as soon as you remember. Especially with indications for taking several times a day, the time between 2 doses should be at least 4 hours apart. If it is almost time for your next dose, do not take the dose you missed and wait until the scheduled time for your next dose. Do not take a double dose of Ocupal to make up for a missed dose.
Treatment of overdose: There is currently no effective antidote if an overdose occurs. It is necessary to monitor the patient's condition, clear the airway, oxygen if necessary, treat symptoms...

3. Notes when using Opelovax

Treatment with Opelovax must be started as soon as possible at the onset of signs and symptoms of disease (vesicles, itching, burning). Do not use Opelovax when past the expiry date indicated on the package, the tablet changes color, watery, has signs of mold, the blister pack is sealed. Elderly patients often have impaired renal function, so the dose should be adjusted for this group of patients. Both elderly patients and patients with renal impairment are at increased risk of neurotoxic side effects, so careful monitoring of adverse events is warranted. Most of these reactions were generally reversible upon discontinuation of treatment. Pregnant and nursing women should not take Opelovax due to the risk of fetal malformations and harm to the young child. If you experience dizziness, headache while taking Opelovax, you should not drive or operate machinery.

4. Opelovax side effects

Common side effects:
Dizziness, headache, nausea, vomiting, abdominal pain, diarrhea, erythema multiforme, rash, photosensitivity. Rare:
Hematology: Anemia, leukopenia, lymphadenitis, thrombocytopenia. Hemolytic uremic syndrome, thrombocytopenic purpura, and sometimes fatal outcome have occurred in immunocompromised patients receiving high doses of aciclovir. Central nervous system: agitated behavior. Uncommon are neurological or psychiatric reactions (, tremors, confusion, lethargy, hallucinations, seizures). Skin: Rash, pruritus, urticaria. Other reactions: pain, fever, increased liver test, jaundice, hepatitis, myalgia, angioedema, hair loss. Management of unwanted side effects: Undesirable side effects are rare and are mild and usually resolve on their own. If the patient experiences severe symptoms (confusion, coma in patients with renal failure), the drug must be stopped immediately. The course is usually good after stopping the drug, so hemodialysis is rarely required.

5. Opelovax drug interactions

Probenecid when co-administered with aciclovir-containing products increases the plasma half-life and AUC of aciclovir, but reduces the clearance and urinary excretion of aciclovir. Concomitant use of zidovudine and acyclovir-containing products may cause lethargy and drowsiness. Patients should be closely monitored when these two drugs are combined. Note when using Amphotericin B and ketoconazole with Opelovax because these two drugs increase the antiviral potency of acyclovir. Acyclovir is incompatible with blood products, foscarnet and solutions containing proteins. This interaction should be taken into account.

6. How to store Opelovax

The shelf life of Opelovax is 36 months from the date of manufacture. Store medicinal products at a suitable room temperature from 15 to 25 degrees Celsius, do not expose the drug to direct sunlight, locations with high heat sources such as next to televisions, heaters or refrigerators that are easy to conduct. to the pill being modified. Avoid storing medicine in humid places such as bathrooms, or places with high humidity below 70% that easily breed mold. Medicines should be kept out of reach of small children. Opelovax is a prescription medicine, indicated for the prevention of reinfection and for the treatment of herpes simplex virus infections. To ensure the effectiveness of using Opelovax, patients also need to follow the instructions of a specialist.
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