Uses of Oftabra

This is an automatically translated article.

1. What is Oftabra?

Oftabra is a product in the eye treatment group with the active ingredient Tobramycin 0.3%. Oftabra medicine is prepared in the form of eye ointment and packed in each box, including 1 tube of 3 grams with a volume of 5ml
Oftabra is a product of Quang Binh Pharmaceutical Joint Stock Company (Vietnam), circulated with registration number VD-13866 -11.

2. What are the effects of Oftabra?

The active ingredient Tobramycin in Oftabra is an aminoglycoside antibiotic prepared from the culture medium of Streptomyces tenebarius. Tobramycin is an antibiotic with bactericidal action and is sensitive to many strains of Gram-negative and Gram-positive aerobic bacteria:
Gram-positive aerobic bacteria: Staphylococcus aureus; Gram-negative aerobic bacteria: Citrobacter sp., Enterobacter sp., Escherichia coli, Klebsiella sp., Morganella morganii, Pseudomonas aeruginosa, Proteus mirabilis, Proteus vulgaris, Providencia sp., Serratia sp. Tobramycin is not effective against Chlamydia, fungi, viruses and most anaerobic bacteria.
The exact mechanism of action of Tobramycin has not yet been fully determined. However, the highest hypothesis is due to inhibition of protein synthesis in susceptible bacteria through irreversible binding to the 30S ribosomal subunit.

3. Indications and contraindications of Oftabra

Oftabra Ophthalmic Ointment is a topical antibiotic indicated for the treatment of extraocular and adnexal infections of the eye caused by strains of bacteria susceptible to Tobramycin. When receiving Oftabra, patients should be monitored for bacterial response to appropriate topical antibiotic therapy.
Note: Clinical studies have shown Oftabra to be safe and effective when used in children.
Do not use Oftabra in patients who are hypersensitive to Tobramycin or any of the excipients with the product.

4. Dosage, how to use Oftabra

Patients only use Oftabra drug prescribed by the doctor with the recommended dose as follows:
Mild to moderate disease: Apply 1.5cm strip of Oftabra ointment to the affected eye 2 to 3 times daily; For severe infections: Apply a 1.5cm strip of Oftabra ointment to the affected eye every 3 or 4 hours until the disease improves, then reduce the dose before stopping the drug completely. Some notes on the dosage of Oftabra:
Oftabra eye ointment can be used in combination with eye drops containing the antibiotic Tobramycin; Oftabra can be used in children, however, the safety and effectiveness of Tobramycin ophthalmic ointment for children under 1 year of age have not been established; Use in patients with hepatic or renal impairment: The safety and efficacy of Oftabra ophthalmic ointment have not been established in this population; Use in the elderly: In general, there is no clinically relevant difference in the use of Oftabra in the elderly and in other adult patients. How to use Oftabra ophthalmic ointment :
Oftabra products are used by eye ointment only; To avoid contamination of the tip of the tube, the patient should be careful not to allow the Oftabra tip to come into direct contact with the eyelids, periorbital area or any other surface; Close the cap of Oftabra vial tightly when not in use; If used concurrently with eye drops, Oftabra should be used at least 5 minutes apart from other preparations and eye ointment should always be used last. Overdose of Oftabra:
Due to the characteristics of this dosage form, there is no toxicity when overdosing on the eye of Oftabra or mistakenly using the gastrointestinal tract; Clinical signs and symptoms of Overdose of Oftabra ophthalmic ointment may include spotted keratitis, erythema, lacrimation, eyelid edema and itching... may be similar to the reactions. Adverse reactions were observed in some patients; When an overdose of Oftabra is applied to the eye, the patient can rinse the eye under warm water to remove the drug.

5. Side effects of the drug Oftabra

Side effects of the drug Oftabra may occur during use as follows:
The most common side effects when using Oftabra are discomfort or eye congestion; Headache; Keratitis, corneal slip; Visual impairment, blurred vision; Erythema of the eyelids; Conjunctival edema, eyelid edema; Eye pain, dry eyes; discharge, itching, or increased tearing; Sensitivity to topical aminoglycoside antibiotics may occur in some patients, therefore it is important to monitor total serum concentrations of Tobramycin when Oftabra is used concomitantly with systemic aminoglycoside antibiotics. .

6. Oftabra Drug Interactions

Drug interaction studies involving Oftabra ophthalmic ointment have not been conducted. However, to date, no clinical drug interactions have been reported with regard to ophthalmic ointment products.

7. Precautions when using Oftabra

Some patients may be sensitive to Aminoglycoside antibiotics (including Tobramycin) used topically, therefore Oftabra should be discontinued if hypersensitivity occurs during treatment with this product. Beware of cross-sensitivity to Tobramycin with other aminoglycoside antibiotics, consideration should be given to the possibility that the patient is sensitive to Oftabra ophthalmic ointment if there is a prior history of known allergy to these medicinal products. Aminoglycosides for other ocular and/or systemic administration. Serious adverse events including neurotoxicity, ototoxicity and nephrotoxicity have occurred in patients treated with systemic Tobramycin. Therefore, caution should be exercised when Oftabra is co-administered with systemic Tobramycin antibiotic preparations, and total serum concentrations of Tobramycin should be monitored carefully. Similar to the use of other antibiotics, prolonged use of Oftabra ophthalmic ointment may cause overgrowth of non-susceptible strains of bacteria, including fungi. If superinfection occurs, the patient should be treated appropriately and promptly. Wearing contact lenses is not recommended during the treatment of eye infections with Oftabra. Oftabra Ophthalmic Ointment has no or negligible influence on the patient's ability to drive and use machines. However, some side effects such as temporary blurred vision or other vision disturbances with Oftabra may affect the ability to drive and use machines. Therefore, if this condition occurs, the patient must wait until the vision clears again before driving or operating machinery. There are no or limited data on the use of Tobramycin antibiotic eye drops (including Oftabra) in pregnant women. Animal studies have shown reproductive toxicity of Tobramycin. However, animal studies are not always predictive of human response and Oftabra ophthalmic ointment is not recommended during pregnancy. It is not known whether the antibiotic Tobramycin is excreted in human milk following topical application in the eye. Systemic administration of tobramycin has been determined to be excreted in human milk and a possible risk to the nursing infant cannot be excluded. Because of the potential for adverse effects of Oftabra ophthalmic ointment in nursing infants, the importance of the drug to the mother should be assessed in order to decide whether to discontinue nursing or discontinue the drug. In summary, Oftabra ophthalmic ointment is a topical antibiotic indicated for the treatment of extraocular and adnexal infections of the eye caused by strains of bacteria susceptible to Tobramycin. To ensure the effectiveness of treatment, patients need to carefully read the instructions and strictly follow the instructions of the doctor, professional pharmacist.
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