This is an automatically translated article.
Ocupal is a prescription drug, indicated for the symptomatic treatment of patients with gastritis, gastro-oesophageal reflux disease, after total gastrectomy. To ensure the effectiveness of using Ocupal, patients also need to follow the instructions of a specialist doctor, and refer to more information about the uses of Ocupal in the article below.
1. What are the uses of Ocupal?
1.1. What is Ocupal? Ocupal belongs to the group of gastrointestinal drugs, with the main active ingredient being Domperidone maleate 10mg.
The drug is prepared in the form of 10 blister tablets, box of 10 blisters.
Ocupal is recommended for use by both adults and children.
1.2. What does Ocupal do? Domperidone maleate is used for the symptomatic treatment of acute nausea and vomiting, including nausea and vomiting associated with levodopa or bromocriptine administration, in patients with Parkinson's disease. However, Domperidone does not cause psychomotor or neurological effects.
Ocupal is prescribed in the following cases:
Treatment of symptoms of nausea, vomiting, abdominal bloating, loss of appetite, indigestion, heartburn, belching for:
Adults: with chronic gastritis, reflux esophagitis, gastric prolapse, symptoms after gastrectomy, the patient is taking anticancer drugs or Levodopa; Promotes gastric motility in mild paralytic ileus in patients with diabetes, after meals because food slows down into the intestines. Children: treatment of cyclic vomiting, upper respiratory infections, taking anti-cancer drugs. Contraindications:
Patients who are allergic to the main active ingredient Domperidone or any of the excipients of Ocupal. Patients with cardiac conduction disorders or heart disease. Patients with moderate to severe hepatic impairment. Patients receiving concomitant therapy with drugs that prolong the QT interval, or with strong inhibitors of CYP3A4 (eg, ketoconazole, cimetidine, erythromycin) because Ocupal has the potential to increase the risk of prolongation of the QT interval on the electrocardiogram. The patient is taking a combination of antiemetics that block neurokinin-1 receptors in the brain. Patients with gastrointestinal bleeding or gastrointestinal perforation. Mechanical bowel obstruction. The patient has a prolactin-secreting pituitary tumor (prolactinoma). Group of pregnant women.
2. How to use Ocupal
2.1. How to take Ocupal Ocupal drug is taken orally, should be taken 15 to 30 minutes before meals. It is recommended that Ocupal be used at the lowest effective dose possible. Take Ocupal tablets whole with filtered or boiled water, do not crush or break them, or mix them with any solution or mixture. Use exactly as prescribed by your doctor, not taking more than the prescribed dose may increase side effects or less, leading to insufficient blood levels of Ocupal to take full advantage. 2.2. Dosage of Ocupal Nausea or vomiting of any cause:
Adults: 10 to 20mg every 4-8 hours Children: 0.2 to 0.4mg/kg every 4-8 hours. Symptoms of indigestion:
Adults: 10-20mg, 3 times a day before meals and 10 to 20mg in the evening, the duration of use of Ocupal should not exceed 12 weeks. Prophylaxis of postoperative vomiting is not recommended.
Dealing with missed doses:
To achieve the antiemetic effect, try not to forget the medicine, if you miss the medicine, you need to take it as soon as you remember. Especially with indications for taking several times a day, the time between 2 doses should be at least 4 hours apart. If it is almost time for your next dose, do not take the dose you missed and wait until the scheduled time for your next dose. Do not take a double dose of Ocupal to make up for a missed dose. Management of Overdose:
Overdosage with Domperidone has been reported mainly in infants and children. Overdose symptoms include cognitive impairment, agitation, convulsions, somnolence, disorientation, and extrapyramidal reactions. There is currently no specific antidote for Domperidone. In case of overdose, immediate symptomatic treatment should be taken. Electrocardiogram monitoring is recommended due to the potential for prolongation of the QT interval. Gastric lavage as well as activated charcoal may be helpful. Recommend close monitoring and supportive treatment for patients. Anticholinergics or antiparkinsonian drugs may be helpful in controlling extrapyramidal reactions.
3. Notes when using Ocupal
Contraindicated Ocupal for patients with prolonged conduction time of cardiac impulses, especially QT interval, patients with marked electrolyte disturbances (hyperkalemia, hypokalemia, hypomagnesaemia), bradycardia or patients with existing cardiovascular abnormalities such as congestive heart failure due to an increased risk of ventricular arrhythmias. These are the same factors that increase the risk of arrhythmias. The half-life of Domperidone is prolonged in patients with severe renal impairment. In cases where repeated administration is required, the frequency of taking Ocupal should be reduced to 1 to 2 times a day depending on the degree of renal impairment, and the dose may need to be adjusted if necessary. Domperidone is excreted in human milk. Adverse effects, especially cardiovascular effects, can still occur when infants are breastfed. Ocupal should be used with caution in the presence of risk factors for prolongation of the QT interval in a nursing infant. Do not use Ocupal when the expiry date indicated on the package has expired, the tablet changes color, is watery, has signs of mold, or the blister pack is sealed.
4. Ocupal side effects
Uncommon:
Gastrointestinal: Vomiting, nausea, diarrhea, dry mouth. Central nervous system: Headache, insomnia. Rare
Causes CNS effects such as extrapyramidal reactions (including acute dystonia and neuroleptic malignant syndrome), convulsions. Extrapyramidal disturbances and somnolence occur at a very low rate and are usually caused by disturbances in the permeability of the blood-brain barrier in premature infants, meningeal lesions, or drug overdose. Lactation, breast enlargement or tenderness, menstrual disorders, amenorrhea, decreased pleasure due to increased serum prolactin may be observed in patients taking high doses of the drug for a long time. The risk of severe ventricular arrhythmias or sudden cardiovascular death was higher in patients taking daily doses above 30 mg and in patients over 60 years of age. Allergic reactions including anaphylaxis, urticaria, and Quincke's edema have been reported very rarely with domperidone.
5. Ocupal drug interactions
Concomitant use of Ocupal with the following drugs
Drugs that prolong the QT interval (risk of torsade de pointes). Class IA antiarrhythmic drugs (eg, Disopyramide, Hydroquinidine, Quinidine). Class III antiarrhythmic drugs (eg, Amiodarone, Dofetilide, Dronedarone, Ibutilide, Sotalol). Certain antipsychotics (eg, Haloperidol, Pimozide, Sertindole). Certain antidepressants (eg, Citalopram, Escitalopram). Certain antibiotics (eg, Erythromycin, Levofloxacin, Moxifloxacin, Spiramycin). Certain antifungals (eg, Fluconazole, Pentamidine). Some antimalarial drugs (especially Halofantrin, Lumefantrine). Certain gastro-intestinal drugs (eg, Cisaprid, Dolasetron, Prucalopride). Certain antihistamines (eg, Mequitazine, Mizolastine). Certain cancer medications (eg, Tamoxifen, Vandetanib, Vincamine). Certain other medicines (eg, Bepridil, Diphemanil, Methadone). Strong CYP3A4 inhibitor (independent of QT prolongation), eg protease inhibitors (eg, ritonavir, saquinavir, telaprevir). Systemic azole antifungals (eg, Itraconazole, Ketoconazole, Posaconazole, Voriconazole). Some macrolides (Erythromycin, Clarithromycin and Telithromycin). Co-administration of Ocupal with the following drugs is not recommended: Moderate CYP3A4 inhibitors, e.g. Diltiazem, Verapamil and some macrolides.
Use with caution when co-administered with the following drugs: Bradycardia drugs, drugs that lower blood potassium and some macrolides that contribute to prolongation of the QT interval: Azithromycin and Roxithromycin (clarithromycin is contraindicated because it is an inhibitory drug). strong CYP3A4 inhibitor).
6. How to store Ocupal
The shelf life of Ocupal medicine is 36 months from the date of manufacture. Store the medicinal product at a suitable room temperature below 30 degrees Celsius, do not expose the medicine to direct sunlight, and locations with high heat sources such as next to the TV, heater or refrigerator can easily lead to modified pills. Avoid storing the medicine in humid places such as in the bathroom, or places with high humidity < 70% where mold can easily arise. Medicines should be kept out of reach of small children. Above is important information about Ocupal medicine, before using, patients need to carefully read the instructions and follow the instructions of a specialist doctor to get the best results.
