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Octreotide is also known as Sandostatin. The active ingredient is Octreotide, a synthetic compound derived from Somatostatin. The drug works by inhibiting the influence of certain hormones. The advantage of the stronger active ingredient Octreotide over Somatostatin is that the therapeutic effect lasts longer.1. What is Octreotide?
Drug class: Octreotide belongs to a group of drugs that treat cancer and affect the body's immune system.
Active ingredient name: Octreotide acetate.
Similar brand name: DBL Octreotide or Asoct, ..
Octreotide is also known as Sandostatin. This is a hormone that occurs naturally in the body. It is used to treat carcinoid syndrome in people with carcinoids or neuroendocrine tumors. These tumors cause the body to overproduce certain hormones, leading to signs known collectively as "carcinoid syndrome".
2. The effect of the drug Octreotide
Treatment for acromegaly. People who are unsuitable or unresponsive to surgical treatment, radiation therapy, or in the waiting period until radiation therapy is fully effective. Treatment of people with signs and symptoms related to functional gastrointestinal endocrine tumors. Carcinoid tumor with signs of carcinoid syndrome. These tumors produce intestinal vasoactive peptides. Pancreatic islet alpha cell tumor. Gastrin-secreting cell tumor/Zollinger-Ellison syndrome. Insulin-secreting cell tumors of the pancreas to control hypoglycemia preoperatively and in maintenance therapy. GRF secreting growth hormone-releasing factor cell tumor. Treatment of people with advanced neuroendocrine tumors of mesenteric origin or unknown primary tumor location
3. How to use Octreotide?
The short-acting form of octreotide is given as an injection under the skin (subcutaneously) or intravenously (IV). Dosage depends on how your body responds and is given several times a day. For chronic treatment, you usually receive a short-acting medication at first, and if this relieves their symptoms, your doctor may prescribe a long-acting therapeutic dose. Octreotide may interact with other medications, including cyclosporin, insulin, oral diabetes medications, and many other mediators. You need to tell your treating doctor about all medications and supplements you are taking.
4. Undesirable effects when using Octreotide
Here are some of the most common side effects when using Octreotide:
Pain at the injection site: Because Octreotide is made as an injection, you may experience local reactions after injection. The injection site may be painful, red, or swollen. This usually lasts less than 10-15 minutes after the short-acting form and an hour after the long-acting form. Effects on the digestive system: When using the drug Octreotide can experience many undesirable effects on the digestive system. Specifically, diarrhea, gas, bloating, and abdominal pain have been reported in studies. Nausea or vomiting a lot: You can control vomiting after taking this medicine by changing your diet, limiting your intake of fatty, spicy or acidic foods (lemon, tomatoes, etc.) Orange). You can make a warm cup of ginger tea to ease the symptoms. Gallstones: Octreotide can affect your gallbladder and cause gallstones or bile abnormalities, including jaundice, in people who have used it for a long time. Some of the warning signs of gallstones include sudden abdominal pain, fever, nausea or vomiting, dark yellow urine, pale stools, and yellow eyes or skin. Heart problems: Octreotide can cause heart rhythm problems such as slow or irregular heartbeat. Notify your treating doctor immediately if you feel an irregular heartbeat or feel dizzy or faint. Changes in blood sugar: Octreotide may lower or increase blood sugar in people with or without diabetes. Some warning signs of a change in blood sugar include shaking, nervousness, anxiety, sweating, chills, hot flashes, fast heartbeat or headache or increased thirst, urination or hunger, blurred vision headache, or your breath has a fruity smell (symptoms of high blood sugar). Less common side effects:
Thyroid problems: Octreotide can cause hypothyroidism (underactive thyroid). Your doctor may order blood tests to check your thyroid's function and treat this side effect if it develops. Symptoms of thyroid problems include fatigue, feeling hot or cold, voice changes, weight gain or loss, hair loss, and muscle cramps. Report any of these symptoms to medical professionals.
5. Notes when using drugs with special target groups
Patients with renal impairment: No dose adjustment of Octreotide is necessary. Hepatic impairment: Elimination may be reduced in patients with cirrhosis, but is not affected in patients with fatty liver disease. Elderly: In a subcutaneous octreotide study, no dose adjustment was necessary in subjects ≥65 years of age. For children: There is not much experience in the use of Octreotide in children. Pregnancy: There are no adequate and well-controlled studies in pregnant women. Most of the cases recorded were normal births, but there were still some cases of spontaneous abortion in the first 3 months and some cases of abortion. No cases of congenital anomalies or malformations associated with the use of Octreotide in pregnancy outcomes were noted. However, the drug Octreotide should only be used in pregnant women under mandatory indications. Lactation: It is not known whether Octreotide is excreted in human milk. Animal studies have shown that Octreotide is excreted in human milk. You should not breast-feed during treatment with Sandostatin. Women of fertility: Currently, there are no studies to prove whether Octreotide affects human fertility or not. Above are the uses, doses and precautions when using Octreotide. To use Octreotide safely and effectively, you need to take it exactly as prescribed by your doctor.
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