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Nozaxen belongs to the group of gastrointestinal drugs with the main ingredient esomeprazole, often used to treat gastroesophageal reflux disease, H. pylori eradication, Zollinger-Ellison syndrome. So how does Nozaxen work?
1. What are the effects of Nozaxen?
What does Nozaxen do? Nozaxen has the main ingredient esomeprazole, which reduces gastric acid secretion by a specific mechanism of action that specifically inhibits the acid pump in parietal cells. Esomeprazole sodium is a weakly alkaline substance that is concentrated and converted to the active form in the highly acidic environment of the secretory tubules of the parietal cells of the stomach (parietal cell endothelial tubules), where it inhibits H+-K+-ATPase (acid pump) and inhibits both basal and stimulated secretions.
After 5 days of oral administration of 20 mg and 40 mg esomeprazole, gastric pH > 4 was maintained for a median of 13-17 h over 24 h in patients with symptomatic GERD. However, after long-term treatment with anti-gastric acid secretion drugs, gastric gland cysts have been reported to occur relatively more frequently. These cystic changes are the physiological result of a strong inhibition of gastric acid secretion but are benign and reversible.
Nozaxen is usually indicated in the following cases:
Gastroesophageal reflux disease (GERD) Reflux esophagitis Long-term treatment for patients with healed esophagitis to prevent recurrence Treatment combined with antibiotics to eradicate Helicobacter Pylori and heal peptic ulcers infected with H.pylori Prevention of recurrence of peptic ulcers in patients with H.pylori infection Does the patient need anti-inflammatory therapy? Continuous steroid (NSAID) therapy, NSAID-induced gastric ulcer healing Long-term treatment after intravenous peptic ulcer rebleeding prophylaxis Treatment Zollinger Ellison syndrome Nozaxen is contraindicated in patients with a history of hypersensitivity to esomeprazole, the benzimidazole subgroup or any other ingredient in the formulation.
2. Dosage of Nozaxen
Depending on the subjects and treatment goals, the dose of Nozaxen will be different, specifically as follows:
Peptic ulcer: 20 mg/day for 2-4 weeks Gastric ulcer and pharyngitis Reflux management: 20 mg/day x 4-8 weeks May be increased to 40 mg/day in patients resistant to other therapies Zollinger-Ellison syndrome 60 mg/day Prophylaxis of recurrent gastric and duodenal ulcers : 20-40 mg/day No dose adjustment is required in patients with renal impairment, patients with severe hepatic impairment use a maximum dose of 20 mg/day.
3. Nozaxen side effects
In some patients when using Nozaxen can experience the following side effects:
Headache Abdominal pain, diarrhea, flatulence, nausea, constipation Dermatitis, itching, urticaria, dizziness, dry mouth Angioedema, anaphylaxis, elevated liver enzymes Paresthesia, somnolence, dizziness, confusion Gynecomastia Inflammation of the stomatitis and gastrointestinal candidiasis Decrease in white blood cells, platelets, agranulocytosis Arthralgia , muscle weakness, myalgia Rash, photosensitivity erythema multiforme, Steven-Johnson syndrome, toxic epidermal necrolysis Angioedema, bronchospasm, fever, increased sweating
4. Be careful when using Nozaxen
Some general notes when using Nozaxen include:
Need to rule out malignancy in case of suspected gastric ulcer before using Nozaxen Caution when using Nozaxen for pregnant and lactating women Nozaxen treatment may slightly increase the risk of gastrointestinal infections caused by Salmonella, Campylobacter Nozaxen may reduce vitamin B12 absorption and lower blood magnesium levels Esomeprazole inhibits CYP2C19, the main enzyme that metabolizes esomeprazole. Therefore, when esomeprazole is co-administered with drugs metabolised by CYP2C29 such as diazepam, citalopram, imipram, plasma concentrations of these drugs may increase and dose reduction may be required. Nozaxen belongs to the group of gastrointestinal drugs with the main ingredient esomeprazole, commonly used to treat gastroesophageal reflux disease, H. pylori eradication, Zollinger-Ellison syndrome. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor.
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