This is an automatically translated article.
Novomix 30 Flexpen medicine has the main ingredient is Insulin. Used in the treatment of insulin-dependent and non-insulin-dependent diabetes mellitus but the drug does not produce the desired effect.
1. What is Novomix?
Novomix Flexpen is a suspension containing soluble insulin aspart and crystalline insulin aspart with protamine in a ratio of 30/70 (equivalent to 3.5mg). The drug is prepared in an injection pen containing 3ml equivalent to 300 units. Insulin aspart is produced by recombinant DNA technology in Saccharomyces cerevisiae (yeast) cells.
In the main ingredient of Novomix Flexpen is Insulin, which has the following effects:
On glucose metabolism: Insulin has the effect of reducing blood glucose, because insulin helps glucose to easily enter cells, especially cells. liver, muscle and adipose tissue, thereby reducing blood glucose. The mechanism of insulin lowering blood glucose is because insulin binds to the receptor, the insulin-receptor complex will autophosphorylate to create a signal to transmit to the storage follicles in the cell, these follicles will move to the cell membrane, mix enter the cell membrane and direct the glucose transporter to the outside of the cell membrane to increase glucose transport into the cell at a rapid rate. When high intracellular glucose levels push insulin out of the receptor, glucose transporters are reabsorbed into the encapsulated capsule to intracellular storage. In addition, insulin also promotes synthesis and inhibits the breakdown of glycogen into glucose released into the blood by stimulating glycogen synthetase and inhibiting glycogen phosphorylase. The nature of insulin is made by the body by beta cells in the pancreas, when there is a lack of insulin, the cells cannot use glucose and glucose in the blood cannot be converted into glycogen for storage in the liver. The consequences of this are hyperglycemia and glucoseuria. On lipid metabolism: Insulin has the effect of increasing the synthesis and storage of lipids in the liver, preventing lipolysis and inhibiting the production of ketones, thereby reducing the concentration of free fatty acids and glycerol in the blood plasma. protid: Insulin promotes protein assimilation by making it easier for amino acids to enter cells to synthesize proteins. Especially in the vessel wall, insulin participates in the creation of glycoproteins in the vessel wall, so if there is a lack of insulin, the vessel wall is vulnerable.
2. Uses of Novomix 30 flexpen
With the effect of regulating blood sugar in the body of insulin, so Novomix 30 flexpen is prescribed by doctors for cases such as:
Patients with type 1 diabetes; Treatment of type 2 diabetes when hypoglycemic agents are ineffective. Note that this drug is contraindicated when:
Patients with a history of sensitivity or hypersensitivity to insulin aspart and other components of the drug; Because the drug has a hypoglycemic effect, the drug is not indicated for use in patients with hypoglycemia.
3. How to use and dosage of Novomix 30 Flexpen
3.1. How to use Novomix 30 Flexpen Novomix 30 flexpen is prepared in the form of a suspension and is available in an injection pen for subcutaneous use. Notes on the use of Novomix 30 Flexpen:
You need to store the injection pen very carefully to avoid infection; Before using the drug, it is necessary to shake it gently so that the suspension in the injection pen is uniform; The injection pen has a part to adjust the appropriate dose, so before using it, it is necessary to adjust the dose you need to use; Subcutaneous injection of injectable areas such as thighs, abdomen, buttocks and deltoid ; Due to the potential to affect lipid metabolism, you need to pay attention to change the injection site continuously to avoid lipodystrophy, and at the same time reduce drug accumulation in one area and cause swelling in the injection area; After the injection is complete, it is necessary to close the cap immediately and store it to avoid some agents such as bacteria, chemicals, etc., that can enter the injection pen. 3.2. Dosage of Novomix 30 Flexpen Drug dosage varies based on many factors such as the patient's condition, concomitant medications, comorbidities, tolerance and effects of the drug.
For patients who have never used insulin, it can be used with an initial dose of 6 units / time and 2 times a day, then 12 units / time / day can be used.
Care should be taken to adjust the dose for:
People who are suffering from infection and fever; Comorbidities in the kidneys, liver or diseases affecting the adrenal gland, pituitary gland or thyroid gland; People who are increasing their physical activity; Change your diet; Are taking with drugs that slow down the absorption of food; Switching from insulin preparations to another; For people > 75 years old, lactating women. You should report to your doctor about your medical history and the use of drugs, diet so that the dose can be adjusted appropriately, avoiding overdose.
4. What are the side effects when using Novomix 30 flexpen?
Some possible side effects when taking the drug include:
Because the drug has the effect of lowering blood sugar in the body, the side effect of the drug is the risk of causing severe hypoglycemia; Due to the effect on lipid metabolism, when using some patients may experience lipodystrophy; Some case reports show that patients using this drug may experience some side effects related to allergic reactions such as rash, urticaria, itching, swelling...; Other rare side effects: Neuralgia, anaphylaxis. If side effects occur while taking the drug, you should notify your doctor or go to a medical facility for timely treatment and treatment.
5. Notes when using Novomix 30 flexpen
This is a prescription drug, so you absolutely must not use the drug on your own, but need to follow the doctor's prescription. In addition, you need to be guided in the injection or injection by qualified doctors, do not arbitrarily change the dose because of the risk of complications.
You should adjust the diet when you have diabetes appropriately or with type 2 diabetes should combine with the use of treatment drugs to improve the effectiveness of the treatment.
There may be a risk of causing excessive hypoglycemia, so when the patient uses the drug, it is necessary to pay attention to monitor signs such as sweating, tremor, extreme hunger, fatigue ... to detect early onset of low blood sugar. Especially after following a diet or exercising more than before. It is best to test blood sugar before injection and correct dose.
For pregnant and lactating women can use. But there are no clear studies on safety, so it is necessary to consult with a doctor to be carefully considered before using.
Possible drug interactions when taking drugs together:
Reduces insulin requirements: Oral hypoglycemic agents, MAO inhibitors (MAOIs), nonselective beta-blockers, inhibitors ACE inhibitors, Salicylates, Steroids, Sulphonamides. Increases insulin requirements: Oral contraceptives, Thiazide diuretics, Glucocorticoids, thyroid hormone, sympathomimetic agents, growth hormone. Other interactions with Octreotide, Lanreotide and interactions with alcohol. Store medications according to the manufacturer's instructions.
Hope the above information has helped you better understand Novomix 30 flexpen. This is a form of insulin so you need to take the correct dose and as prescribed by your doctor. Do not increase the dose on your own because of the risk of serious and life-threatening hypoglycemia.
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